Literature summary for 1.16.1.8 extracted from

Olteanu, H.; Wolthers, K.R.; Munro, A.W.; Scrutton, N.S.; Banerjee, R.
Kinetic and thermodynamic characterization of the common polymorphic variants of human methionine synthase reductase (2004), Biochemistry, 43, 1988-1997.

Search for more literature for 1.16.1.8

Application

Application	Comment	Organism
medicine	variant M22/S175 is a genetic determinant of plasma homocysteine levels and has been linked to premature coronary artery disease, Downs syndrome, and neural tube defects	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	variant I22/L175	-
Homo sapiens	-	variant M22/S175	-

Cofactor

Cofactor	Comment	Organism	Structure
FAD	contains both FAD and FMN. The values of the midpoint potentials are -236 mV FAD oxidized/semiquinone and -264 mV FAD semiquinone/hydroquinone, variant M22/S175	Homo sapiens
FAD	contains both FAD and FMN. The values of the midpoint potentials are -252 mV FAD oxidized/semiquinone and -285 mV FAD semiquinone/hydroquinone, variant I22/L175	Homo sapiens
FMN	contains both FAD and FMN. The values of the midpoint potentials are -103 mV FMN oxidized/semiquinone and -175 mV FMN semiquinone/hydroquinone, variant I22/L175	Homo sapiens
FMN	contains both FAD and FMN. The values of the midpoint potentials are -114 mV FMN oxidized/semiquinone and -212 mV FMN semiquinone/hydroquinone, variant M22/S175	Homo sapiens

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Release 2023.1 (January 2023)