Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.16.1.8 extracted from

  • Olteanu, H.; Munson, T.; Banerjee, R.
    Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase (2002), Biochemistry, 41, 13378-13385.
    View publication on PubMed
Search for more literature for 1.16.1.8

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0023
-
 2,6-dichlorophenolindophenol variant I22/S175 Homo sapiens
0.0038
-
 2,6-dichlorophenolindophenol variant I22/S175 Homo sapiens
0.0177
-
 menadione variant I22/S175 Homo sapiens
0.0177
-
 3-acetylpyridine adenine dinucleotide phosphate variant I22/S175 Homo sapiens
0.018
-
 menadione variant I22/S175 Homo sapiens
0.018
-
 3-acetylpyridine adenine dinucleotide phosphate variant I22/S175 Homo sapiens
0.0286
-
 doxorubicin variant I22/S175 Homo sapiens
0.0366
-
 doxorubicin variant I22/S175 Homo sapiens
0.663
-
 ferricyanide variant I22/S175 Homo sapiens
0.774
-
 ferricyanide variant I22/S175 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens difference in the relative efficiency of the very common polymorphic variant of the enzyme, I22M, suggests a molecular mechanism underlying the risk associated wiith the M22 allele for mild hyperhomocysteinemia ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UBK8 variant I22/S175
-
Homo sapiens Q9UBK8 variant M22/S175
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information difference in the relative efficiency of the very common polymorphic variant of the enzyme, I22M, suggests a molecular mechanism underlying the risk associated wiith the M22 allele for mild hyperhomocysteinemia Homo sapiens ?
-
 ?
[methionine synthase]-cob(II)alamin + S-adenosyl-L-methionine + 2,6-dichlorophenolindophenol
-
 Homo sapiens [methionine synthase]methylcob(I)alamin + S-adenosylhomocysteine + ?
-
 ?
[methionine synthase]-cob(II)alamin + S-adenosyl-L-methionine + 3-acetylpyridine adenine dinucleotide phosphate
-
 Homo sapiens [methionine synthase]methylcob(I)alamin + S-adenosylhomocysteine + ?
-
 ?
[methionine synthase]-cob(II)alamin + S-adenosyl-L-methionine + doxorubicin
-
 Homo sapiens [methionine synthase]methylcob(I)alamin + S-adenosylhomocysteine + ?
-
 ?
[methionine synthase]-cob(II)alamin + S-adenosyl-L-methionine + ferricyanide
-
 Homo sapiens [methionine synthase]methylcob(I)alamin + S-adenosylhomocysteine + ?
-
 ?
[methionine synthase]-cob(II)alamin + S-adenosyl-L-methionine + menadione
-
 Homo sapiens [methionine synthase]methylcob(I)alamin + S-adenosylhomocysteine + ?
-
 ?

Synonyms

Synonyms Comment Organism
MSR
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.43
-
 2,6-dichlorophenolindophenol variant I22/S175 Homo sapiens
0.86
-
 3-acetylpyridine adenine dinucleotide phosphate variant I22/S175 Homo sapiens
1.61
-
 menadione variant I22/S175 Homo sapiens
1.61
-
 doxorubicin variant I22/S175 Homo sapiens
8.24
-
 ferricyanide variant I22/S175 Homo sapiens