BRENDA - Enzyme Database
show all sequences of 1.15.1.1

Sources of marine superoxide dismutases characteristics and applications

Zeinali, F.; Homaei, A.; Kamrani, E.; Int. J. Biol. Macromol. 79, 627-637 (2015)

Data extracted from this reference:

Application
Application
Commentary
Organism
diagnostics
the SOD in the cosmopolitan sponge Cliona celata is described as a useful biomarker for marine pollution in other marine invertebrates
Cliona celata
diagnostics
the variations of SOD expression pattern in yrtilus. edulis can be used as a tool for the marine environment monitoring
Mytilus edulis
diagnostics
Cu/Zn-SOD might be used as a bioindicator of the aquatic environmental pollution and cellular stress in pearl oyster
Pinctada fucata
Cloned(Commentary)
Commentary
Organism
Cu/Zn-SOD, DNA and amino acid sequence determination and analysis, semi-quantitative and/or real-time RT-PCR enzyme expression analysis; Mn-SOD, DNA and amino acid sequence determination and analysis, semi-quantitative and/or real-time RT-PCR enzyme expression analysis
Haliotis discus discus
cytoplasmic manganese SOD, DNA and amino acid sequence determination and analysis
Penaeus vannamei
DNA and amino acid sequence determination and analysis
Bruguiera gymnorhiza
gene dhsod-1, DNA and amino acid sequence determination and analysis, sequence comparisons
Debaryomyces hansenii
gene Sod1, a single copy, expression analysis, recombinant expression in transgenic Oryza sativa plants, plants are more tolerant to methyl viologen mediated oxidative stress in comparison to the untransformed control plants and also withstand salinity stress
Avicennia marina
recombinant expression in in a copper-tolerant yeast, Cryptococcus sp. strain N6, two distinct bands exhibiting SOD activity appear on native PAGE: one band, with higher mobility, appears when the cells are grown without CuSO4, and the other band appears when the cells are grown with 10 mM CuSO4. Cells grown with 3 mM CuSO4 produce both SOD isoforms
Schwanniomyces vanrijiae var. vanrijiae
SaFe-SOD, DNA and amino acid sequence determination and analysis, quantitative real-time PCR enzyme expression analysis, functional recombinant expression of His-tagged enzyme in Escherichia coli strain Rosetta-gami
Sonneratia alba
semi-quantitative enzyme expression analysis
Pinctada fucata
Engineering
Amino acid exchange
Commentary
Organism
additional information
the enzyme is not significantly modified in light mitochondrial (LMF) fractions by any treatment
Sparus aurata
General Stability
General Stability
Organism
a stable SOD in a broad pH range from 4 to 12, higher temperature, and in the presence of proteases
Conticribra weissflogii
Inhibitors
Inhibitors
Commentary
Organism
Structure
azide
causes 50% inhibition at 20 mM
Porphyridium purpureum
diethyldithiocarbamate
strong inhibition
Gadus morhua
H2O2
-
Ulva linza
additional information
UV-B radiation decreases the SOD activity
Cylindrotheca closterium
additional information
the enzyme shows good tolerance to some inhibitors, detergents, and denaturants
Geobacillus sp. EPT3
additional information
cyanide at 5 mM and H2O2 at 3 mM have no effect on the activity of the enzyme
Porphyridium purpureum
additional information
the enzyme is insensitive to malondialdehyde (MDA) or 4-hydroxy-2-nonenal (HNE); the enzyme is insensitive to malondialdehyde (MDA) or 4-hydroxy-2-nonenal (HNE). Enzyme Mn-SOD is insensitive to cyanide
Sparus aurata
additional information
the enzyme is insensitive to potassium cyanide
Ulva linza
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
chloroplast
-
Ulva linza
9507
-
cytoplasm
-
Penaeus vannamei
5737
-
cytosol
-
Bruguiera gymnorhiza
5829
-
cytosol
three isoforms of Cu/Zn-SOD
Mytilus edulis
5829
-
cytosol
no signal peptide is identified at the N-terminal amino acid sequence of Cu/Zn-SOD indicating that this pfSOD encodes a cytoplasmic Cu/Zn-SOD
Pinctada fucata
5829
-
cytosol
-
Schwanniomyces vanrijiae var. vanrijiae
5829
-
cytosol
-
Sparus aurata
5829
-
extracellular
-
Crassostrea gigas
-
-
mitochondrion
in the light mitochondrial fraction
Sparus aurata
5739
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Cu2+
a Cu/Zn-SOD
Bruguiera gymnorhiza
Cu2+
a Cu/Zn-SOD
Crassostrea gigas
Cu2+
a Cu-Zn-SOD
Debaryomyces hansenii
Cu2+
a Cu/Zn-SOD
Haliotis discus discus
Cu2+
a Cu/Zn-SOD
Lampanyctus crocodilus
Cu2+
a Cu/Zn-SOD
Mytilus edulis
Cu2+
a Cu/Zn-SOD, conserved amino acids required for binding copper and zinc
Pinctada fucata
Cu2+
a Cu/Zn-SOD. The isolated enzyme has 30% of its copper in the reduced state
Prionace glauca
Cu2+
a Cu/Zn-SOD
Schwanniomyces vanrijiae var. vanrijiae
Cu2+
a Cu/Zn-SOD
Sparus aurata
Cu2+
a Cu/Zn-SOD
Xiphias gladius
Fe2+
a Fe-SOD
Lingulodinium polyedra
Fe2+
a Fe-SOD
Nodularia sp. (in: Bacteria)
Fe2+
a Fe-SOD, the dimeric enzyme contains one iron atom/subunit
Photobacterium leiognathi
Fe2+
a Fe-SOD, all iron-binding sites (His 27, His 80, Asp 164 and His 168) of SaFe-SOD are conserved
Sonneratia alba
Fe2+
a Fe-SOD
Ulva linza
Mn2+
a Mn-SOD
Geobacillus sp. EPT3
Mn2+
a Mn-SOD
Haliotis discus discus
Mn2+
a Mn-SOD
Penaeus vannamei
Mn2+
a Mn-SOD, Mn2+ constitutes 0.13% of the enzyme, equivalent to one manganese atom per molecule of enzyme
Porphyridium purpureum
Mn2+
a Mn-SOD
Sparus aurata
additional information
exposure to a pH of 3.8 in the presence of 8.0 M urea labilizes the manganese and allows the preparation of a colorless and inactive apoenzyme, that can be reconstituted by subsequent treatment with MnCl2
Porphyridium purpureum
Zn2+
a Cu/Zn-SOD
Bruguiera gymnorhiza
Zn2+
a Cu/Zn-SOD
Crassostrea gigas
Zn2+
a Cu-Zn-SOD
Debaryomyces hansenii
Zn2+
a Cu/Zn-SOD
Haliotis discus discus
Zn2+
a Cu/Zn-SOD
Lampanyctus crocodilus
Zn2+
a Cu/Zn-SOD
Mytilus edulis
Zn2+
a Cu/Zn-SOD, conserved amino acids required for binding copper and zinc
Pinctada fucata
Zn2+
a Cu/Zn-SOD
Prionace glauca
Zn2+
a Cu/Zn-SOD
Schwanniomyces vanrijiae var. vanrijiae
Zn2+
a Cu/Zn-SOD
Sparus aurata
Zn2+
a Cu/Zn-SOD
Xiphias gladius
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
two distinct bands exhibiting SOD activity appear on native PAGE: one band, with higher mobility, appears when the cells are grown without CuSO4, and the other band appears when the cells are grown with 10 mM CuSO4. Cells grown with 3 mM CuSO4 produce both SOD isoforms
Schwanniomyces vanrijiae var. vanrijiae
46000
-
gel filtration
Ulva linza
130000
-
isozyme 3, native PAGE
Mytilus edulis
155000
-
isozyme 2, native PAGE
Mytilus edulis
205000
-
isozyme 1, native PAGE
Mytilus edulis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2 superoxide + 2 H+
Photobacterium leiognathi
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Porphyridium purpureum
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Mytilus edulis
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Crassostrea gigas
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Gadus morhua
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Penaeus vannamei
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Debaryomyces hansenii
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Lingulodinium polyedra
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Tetraselmis subcordiformis
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Conticribra weissflogii
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Avicennia marina
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Bruguiera gymnorhiza
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Apostichopus japonicus
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Pinctada fucata
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Sonneratia alba
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Tetraselmis gracilis
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Alvinella pompejana
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Haliotis discus discus
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Geobacillus sp. EPT3
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Sparus aurata
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Photobacterium sepia
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Nodularia sp. (in: Bacteria)
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Minutocellus polymorphus
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Cylindrotheca closterium
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Ulva linza
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Schwanniomyces vanrijiae var. vanrijiae
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Lampanyctus crocodilus
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Xiphias gladius
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Prionace glauca
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Cliona celata
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Schwanniomyces vanrijiae var. vanrijiae 020
-
O2 + H2O2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Alvinella pompejana
-
from chimney walls of deep sea hydrothermal vents along the East Pacific Rise
-
Apostichopus japonicus
-
-
-
Avicennia marina
-
-
-
Bruguiera gymnorhiza
-
-
-
Cliona celata
-
-
-
Conticribra weissflogii
-
-
-
Crassostrea gigas
-
-
-
Cylindrotheca closterium
-
-
-
Debaryomyces hansenii
-
-
-
Gadus morhua
-
-
-
Geobacillus sp. EPT3
T1T1K2
-
-
Haliotis discus discus
-
-
-
Lampanyctus crocodilus
-
-
-
Lingulodinium polyedra
-
formerly Gonyaulax polyedra
-
Minutocellus polymorphus
-
-
-
Mytilus edulis
-
three isoforms of Cu/Zn-SOD
-
Nodularia sp. (in: Bacteria)
-
-
-
Penaeus vannamei
-
-
-
Photobacterium leiognathi
-
-
-
Photobacterium sepia
-
-
-
Pinctada fucata
-
-
-
Porphyridium purpureum
-
-
-
Prionace glauca
-
-
-
Schwanniomyces vanrijiae var. vanrijiae
-
-
-
Schwanniomyces vanrijiae var. vanrijiae 020
-
-
-
Sonneratia alba
-
-
-
Sparus aurata
M9NZV8
-
-
Sparus aurata
M9P0B0
-
-
Tetraselmis gracilis
-
-
-
Tetraselmis subcordiformis
-
-
-
Ulva linza
-
-
-
Xiphias gladius
-
-
-
Purification (Commentary)
Commentary
Organism
Cu/Zn-SOD from digestive gland and gills
Mytilus edulis
Cu/Zn-SOD isozyme; Mn-SOD isozyme
Sparus aurata
from liver
Xiphias gladius
native enzyme by ammonium sulfate fractionation, ion exchange chromatography, and gel filtration
Ulva linza
native enzyme to homogeneity
Porphyridium purpureum
recombinant His-tagged enzyme from Escherichia coli strain Rosetta-gami by nickel affinity chromatgraphy
Sonneratia alba
Source Tissue
Source Tissue
Commentary
Organism
Textmining
digestive gland
-
Mytilus edulis
-
flower
-
Sonneratia alba
-
fruit
-
Sonneratia alba
-
gill
-
Mytilus edulis
-
gill
cytoplasmic manganese SOD
Penaeus vannamei
-
gill
-
Pinctada fucata
-
heart
cytoplasmic manganese SOD
Penaeus vannamei
-
hemocyte
Cg-EcSOD-expressing hemocytes were seen in blood circulation, in connective tissues, and closely associated to endothelium blood vessels. Cg-EcSOD presents in its amino acid sequence a LPS-binding motif found in the endotoxin receptor CD14, the protein displays an affinity to Escherichia coli bacteria and to LPS and lipid A
Crassostrea gigas
-
hemocyte
cytoplasmic manganese SOD
Penaeus vannamei
-
hemocyte
-
Pinctada fucata
-
hepatopancreas
cytoplasmic manganese SOD
Penaeus vannamei
-
intestine
cytoplasmic manganese SOD
Penaeus vannamei
-
leaf
-
Bruguiera gymnorhiza
-
leaf
highest expression in leaf tissues
Sonneratia alba
-
liver
-
Xiphias gladius
-
additional information
semi-quantitative enzyme expression analysis in adult tissues shows that the pfSOD mRNA is abundantly expressed in hemocytes and gill and scarcely expressed in other tissues tested
Pinctada fucata
-
additional information
quantitative real-time PCR enzyme tissue expression analysis
Sonneratia alba
-
muscle
cytoplasmic manganese SOD
Penaeus vannamei
-
nervous system
cytoplasmic manganese SOD
Penaeus vannamei
-
plasma
-
Crassostrea gigas
-
pleopod
cytoplasmic manganese SOD
Penaeus vannamei
-
root
-
Sonneratia alba
-
stem
-
Sonneratia alba
-
trichome
-
Nodularia sp. (in: Bacteria)
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
value of SOD activity is 163.4 U/g total protein in wet tissues
Cliona celata
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2 superoxide + 2 H+
-
745093
Photobacterium leiognathi
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Porphyridium purpureum
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Mytilus edulis
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Crassostrea gigas
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Gadus morhua
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Penaeus vannamei
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Debaryomyces hansenii
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Lingulodinium polyedra
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Tetraselmis subcordiformis
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Conticribra weissflogii
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Avicennia marina
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Bruguiera gymnorhiza
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Apostichopus japonicus
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Pinctada fucata
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Sonneratia alba
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Tetraselmis gracilis
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Alvinella pompejana
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Haliotis discus discus
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Geobacillus sp. EPT3
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Sparus aurata
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Photobacterium sepia
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Nodularia sp. (in: Bacteria)
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Minutocellus polymorphus
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Cylindrotheca closterium
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Ulva linza
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Schwanniomyces vanrijiae var. vanrijiae
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Lampanyctus crocodilus
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Xiphias gladius
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Prionace glauca
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Cliona celata
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Schwanniomyces vanrijiae var. vanrijiae 020
O2 + H2O2
-
-
-
?
additional information
the extracellular enzyme appears to bind lipopolysaccharides, recognition mechanisms can be provided by several actors which can interplay such as plasma LBP-binding protein (LBP), membrane bound or soluble forms of CD14 and integrins
745093
Crassostrea gigas
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 15920, sequence calculation, x * 18000, SDS-PAGE
Debaryomyces hansenii
?
x * 37600
Lampanyctus crocodilus
?
x * 15800-16600 , two isozymes, sequence calculation, x * 18000, SDS-PAGE
Schwanniomyces vanrijiae var. vanrijiae
?
x * 30000, about, sequence calculation, x * 25000, recombinant enzyme, SDS-PAGE
Sonneratia alba
homodimer
2 * 40000
Porphyridium purpureum
homodimer
2 * 23000, SDS-PAGE
Ulva linza
monomer
1 * 50230, sequence calculation, 1 * 59000, SDS-PAGE
Geobacillus sp. EPT3
More
amino acid sequence comparisons, the swortfish SOD has a higher content of arginine and tyrosine than the corresponding bovine enzyme and appears to dissociate more readily into subunits. The swortfish enzyme has a higher content of arginine and tyrosine, high homology with the other eukaryotic enzymes,and low homology with the Photobacterium leiognuthi enzyme
Xiphias gladius
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Sonneratia alba
35
-
-
Ulva linza
Temperature Range [°C]
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
-
35
maximal enzyme activity at 35°C, and 29.8% relative activity at 0°C
Ulva linza
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
additional information
-
a highly thermostable enzyme, occurrence of an additional sulfur-containing hydrogen bond involving the M110 residue and the effect of the A138 residue on the backbone entropy
Alvinella pompejana
additional information
-
high thermostability
Gadus morhua
additional information
-
a higher thermostable enzyme
Lampanyctus crocodilus
additional information
-
a highly thermostable enzyme
Photobacterium leiognathi
additional information
-
a highly thermostable enzyme
Photobacterium sepia
additional information
-
a thermostable enzyme
Sonneratia alba
40
-
stable below
Ulva linza
50
-
highly thermostable at
Geobacillus sp. EPT3
65
-
purified enzyme, half-life is 110 min
Alvinella pompejana
80
-
purified enzyme, half-life is 9.8-20.8 min
Alvinella pompejana
100
-
purified enzyme, strong stability at pH 6.0-7.0, the enzyme survives boiling for 10 min without losing more than 60% of activity
Debaryomyces hansenii
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
3.5
9.5
stable at, 25°C
Sonneratia alba
4
12
stable at
Conticribra weissflogii
5
10
stable at
Ulva linza
5
11
quite stable at
Geobacillus sp. EPT3
6
7
purified enzyme, strong stability at pH 6.0-7.0, the enzyme survives boiling for 10 min without losing more than 60% of activity
Debaryomyces hansenii
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Prionace glauca
the enzyme has a low isoelectric point
-
additional information
Debaryomyces hansenii
two pI ranges: 5.14-4.0 and 1.6-1.8, isoelectric focusing
1.8
1.6
Debaryomyces hansenii
two pI ranges: 5.14-4.0 and 1.6-1.8, isoelectric focusing
5.14
4
Photobacterium sepia
-
-
4.1
Porphyridium purpureum
isoelectric focusing
-
4.2
Photobacterium leiognathi
-
-
4.4
Mytilus edulis
isozyme 3, isoelectric focusing
-
4.55
Mytilus edulis
isozyme 1, isoelectric focusing
-
4.6
Geobacillus sp. EPT3
-
-
4.65
Mytilus edulis
isozyme 2, isoelectric focusing
-
4.7
Lampanyctus crocodilus
-
-
6.35
Application (protein specific)
Application
Commentary
Organism
diagnostics
the SOD in the cosmopolitan sponge Cliona celata is described as a useful biomarker for marine pollution in other marine invertebrates
Cliona celata
diagnostics
the variations of SOD expression pattern in yrtilus. edulis can be used as a tool for the marine environment monitoring
Mytilus edulis
diagnostics
Cu/Zn-SOD might be used as a bioindicator of the aquatic environmental pollution and cellular stress in pearl oyster
Pinctada fucata
Cloned(Commentary) (protein specific)
Commentary
Organism
Cu/Zn-SOD, DNA and amino acid sequence determination and analysis, semi-quantitative and/or real-time RT-PCR enzyme expression analysis; Mn-SOD, DNA and amino acid sequence determination and analysis, semi-quantitative and/or real-time RT-PCR enzyme expression analysis
Haliotis discus discus
cytoplasmic manganese SOD, DNA and amino acid sequence determination and analysis
Penaeus vannamei
DNA and amino acid sequence determination and analysis
Bruguiera gymnorhiza
gene dhsod-1, DNA and amino acid sequence determination and analysis, sequence comparisons
Debaryomyces hansenii
gene Sod1, a single copy, expression analysis, recombinant expression in transgenic Oryza sativa plants, plants are more tolerant to methyl viologen mediated oxidative stress in comparison to the untransformed control plants and also withstand salinity stress
Avicennia marina
recombinant expression in in a copper-tolerant yeast, Cryptococcus sp. strain N6, two distinct bands exhibiting SOD activity appear on native PAGE: one band, with higher mobility, appears when the cells are grown without CuSO4, and the other band appears when the cells are grown with 10 mM CuSO4. Cells grown with 3 mM CuSO4 produce both SOD isoforms
Schwanniomyces vanrijiae var. vanrijiae
SaFe-SOD, DNA and amino acid sequence determination and analysis, quantitative real-time PCR enzyme expression analysis, functional recombinant expression of His-tagged enzyme in Escherichia coli strain Rosetta-gami
Sonneratia alba
semi-quantitative enzyme expression analysis
Pinctada fucata
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
the enzyme is not significantly modified in light mitochondrial (LMF) fractions by any treatment
Sparus aurata
General Stability (protein specific)
General Stability
Organism
a stable SOD in a broad pH range from 4 to 12, higher temperature, and in the presence of proteases
Conticribra weissflogii
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
azide
causes 50% inhibition at 20 mM
Porphyridium purpureum
diethyldithiocarbamate
strong inhibition
Gadus morhua
H2O2
-
Ulva linza
additional information
UV-B radiation decreases the SOD activity
Cylindrotheca closterium
additional information
the enzyme shows good tolerance to some inhibitors, detergents, and denaturants
Geobacillus sp. EPT3
additional information
cyanide at 5 mM and H2O2 at 3 mM have no effect on the activity of the enzyme
Porphyridium purpureum
additional information
the enzyme is insensitive to malondialdehyde (MDA) or 4-hydroxy-2-nonenal (HNE)
Sparus aurata
additional information
the enzyme is insensitive to malondialdehyde (MDA) or 4-hydroxy-2-nonenal (HNE). Enzyme Mn-SOD is insensitive to cyanide
Sparus aurata
additional information
the enzyme is insensitive to potassium cyanide
Ulva linza
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
chloroplast
-
Ulva linza
9507
-
cytoplasm
-
Penaeus vannamei
5737
-
cytosol
-
Bruguiera gymnorhiza
5829
-
cytosol
three isoforms of Cu/Zn-SOD
Mytilus edulis
5829
-
cytosol
no signal peptide is identified at the N-terminal amino acid sequence of Cu/Zn-SOD indicating that this pfSOD encodes a cytoplasmic Cu/Zn-SOD
Pinctada fucata
5829
-
cytosol
-
Schwanniomyces vanrijiae var. vanrijiae
5829
-
cytosol
-
Sparus aurata
5829
-
extracellular
-
Crassostrea gigas
-
-
mitochondrion
in the light mitochondrial fraction
Sparus aurata
5739
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Cu2+
a Cu/Zn-SOD
Bruguiera gymnorhiza
Cu2+
a Cu/Zn-SOD
Crassostrea gigas
Cu2+
a Cu-Zn-SOD
Debaryomyces hansenii
Cu2+
a Cu/Zn-SOD
Haliotis discus discus
Cu2+
a Cu/Zn-SOD
Lampanyctus crocodilus
Cu2+
a Cu/Zn-SOD
Mytilus edulis
Cu2+
a Cu/Zn-SOD, conserved amino acids required for binding copper and zinc
Pinctada fucata
Cu2+
a Cu/Zn-SOD. The isolated enzyme has 30% of its copper in the reduced state
Prionace glauca
Cu2+
a Cu/Zn-SOD
Schwanniomyces vanrijiae var. vanrijiae
Cu2+
a Cu/Zn-SOD
Sparus aurata
Cu2+
a Cu/Zn-SOD
Xiphias gladius
Fe2+
a Fe-SOD
Lingulodinium polyedra
Fe2+
a Fe-SOD
Nodularia sp. (in: Bacteria)
Fe2+
a Fe-SOD, the dimeric enzyme contains one iron atom/subunit
Photobacterium leiognathi
Fe2+
a Fe-SOD, all iron-binding sites (His 27, His 80, Asp 164 and His 168) of SaFe-SOD are conserved
Sonneratia alba
Fe2+
a Fe-SOD
Ulva linza
Mn2+
a Mn-SOD
Geobacillus sp. EPT3
Mn2+
a Mn-SOD
Haliotis discus discus
Mn2+
a Mn-SOD
Penaeus vannamei
Mn2+
a Mn-SOD, Mn2+ constitutes 0.13% of the enzyme, equivalent to one manganese atom per molecule of enzyme
Porphyridium purpureum
Mn2+
a Mn-SOD
Sparus aurata
additional information
exposure to a pH of 3.8 in the presence of 8.0 M urea labilizes the manganese and allows the preparation of a colorless and inactive apoenzyme, that can be reconstituted by subsequent treatment with MnCl2
Porphyridium purpureum
Zn2+
a Cu/Zn-SOD
Bruguiera gymnorhiza
Zn2+
a Cu/Zn-SOD
Crassostrea gigas
Zn2+
a Cu-Zn-SOD
Debaryomyces hansenii
Zn2+
a Cu/Zn-SOD
Haliotis discus discus
Zn2+
a Cu/Zn-SOD
Lampanyctus crocodilus
Zn2+
a Cu/Zn-SOD
Mytilus edulis
Zn2+
a Cu/Zn-SOD, conserved amino acids required for binding copper and zinc
Pinctada fucata
Zn2+
a Cu/Zn-SOD
Prionace glauca
Zn2+
a Cu/Zn-SOD
Schwanniomyces vanrijiae var. vanrijiae
Zn2+
a Cu/Zn-SOD
Sparus aurata
Zn2+
a Cu/Zn-SOD
Xiphias gladius
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
two distinct bands exhibiting SOD activity appear on native PAGE: one band, with higher mobility, appears when the cells are grown without CuSO4, and the other band appears when the cells are grown with 10 mM CuSO4. Cells grown with 3 mM CuSO4 produce both SOD isoforms
Schwanniomyces vanrijiae var. vanrijiae
46000
-
gel filtration
Ulva linza
130000
-
isozyme 3, native PAGE
Mytilus edulis
155000
-
isozyme 2, native PAGE
Mytilus edulis
205000
-
isozyme 1, native PAGE
Mytilus edulis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2 superoxide + 2 H+
Photobacterium leiognathi
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Porphyridium purpureum
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Mytilus edulis
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Crassostrea gigas
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Gadus morhua
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Penaeus vannamei
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Debaryomyces hansenii
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Lingulodinium polyedra
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Tetraselmis subcordiformis
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Conticribra weissflogii
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Avicennia marina
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Bruguiera gymnorhiza
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Apostichopus japonicus
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Pinctada fucata
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Sonneratia alba
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Tetraselmis gracilis
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Alvinella pompejana
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Haliotis discus discus
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Geobacillus sp. EPT3
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Sparus aurata
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Photobacterium sepia
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Nodularia sp. (in: Bacteria)
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Minutocellus polymorphus
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Cylindrotheca closterium
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Ulva linza
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Schwanniomyces vanrijiae var. vanrijiae
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Lampanyctus crocodilus
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Xiphias gladius
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Prionace glauca
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Cliona celata
-
O2 + H2O2
-
-
?
2 superoxide + 2 H+
Schwanniomyces vanrijiae var. vanrijiae 020
-
O2 + H2O2
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
Cu/Zn-SOD from digestive gland and gills
Mytilus edulis
Cu/Zn-SOD isozyme
Sparus aurata
from liver
Xiphias gladius
Mn-SOD isozyme
Sparus aurata
native enzyme by ammonium sulfate fractionation, ion exchange chromatography, and gel filtration
Ulva linza
native enzyme to homogeneity
Porphyridium purpureum
recombinant His-tagged enzyme from Escherichia coli strain Rosetta-gami by nickel affinity chromatgraphy
Sonneratia alba
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
digestive gland
-
Mytilus edulis
-
flower
-
Sonneratia alba
-
fruit
-
Sonneratia alba
-
gill
-
Mytilus edulis
-
gill
cytoplasmic manganese SOD
Penaeus vannamei
-
gill
-
Pinctada fucata
-
heart
cytoplasmic manganese SOD
Penaeus vannamei
-
hemocyte
Cg-EcSOD-expressing hemocytes were seen in blood circulation, in connective tissues, and closely associated to endothelium blood vessels. Cg-EcSOD presents in its amino acid sequence a LPS-binding motif found in the endotoxin receptor CD14, the protein displays an affinity to Escherichia coli bacteria and to LPS and lipid A
Crassostrea gigas
-
hemocyte
cytoplasmic manganese SOD
Penaeus vannamei
-
hemocyte
-
Pinctada fucata
-
hepatopancreas
cytoplasmic manganese SOD
Penaeus vannamei
-
intestine
cytoplasmic manganese SOD
Penaeus vannamei
-
leaf
-
Bruguiera gymnorhiza
-
leaf
highest expression in leaf tissues
Sonneratia alba
-
liver
-
Xiphias gladius
-
additional information
semi-quantitative enzyme expression analysis in adult tissues shows that the pfSOD mRNA is abundantly expressed in hemocytes and gill and scarcely expressed in other tissues tested
Pinctada fucata
-
additional information
quantitative real-time PCR enzyme tissue expression analysis
Sonneratia alba
-
muscle
cytoplasmic manganese SOD
Penaeus vannamei
-
nervous system
cytoplasmic manganese SOD
Penaeus vannamei
-
plasma
-
Crassostrea gigas
-
pleopod
cytoplasmic manganese SOD
Penaeus vannamei
-
root
-
Sonneratia alba
-
stem
-
Sonneratia alba
-
trichome
-
Nodularia sp. (in: Bacteria)
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
value of SOD activity is 163.4 U/g total protein in wet tissues
Cliona celata
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2 superoxide + 2 H+
-
745093
Photobacterium leiognathi
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Porphyridium purpureum
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Mytilus edulis
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Crassostrea gigas
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Gadus morhua
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Penaeus vannamei
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Debaryomyces hansenii
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Lingulodinium polyedra
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Tetraselmis subcordiformis
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Conticribra weissflogii
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Avicennia marina
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Bruguiera gymnorhiza
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Apostichopus japonicus
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Pinctada fucata
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Sonneratia alba
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Tetraselmis gracilis
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Alvinella pompejana
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Haliotis discus discus
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Geobacillus sp. EPT3
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Sparus aurata
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Photobacterium sepia
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Nodularia sp. (in: Bacteria)
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Minutocellus polymorphus
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Cylindrotheca closterium
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Ulva linza
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Schwanniomyces vanrijiae var. vanrijiae
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Lampanyctus crocodilus
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Xiphias gladius
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Prionace glauca
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Cliona celata
O2 + H2O2
-
-
-
?
2 superoxide + 2 H+
-
745093
Schwanniomyces vanrijiae var. vanrijiae 020
O2 + H2O2
-
-
-
?
additional information
the extracellular enzyme appears to bind lipopolysaccharides, recognition mechanisms can be provided by several actors which can interplay such as plasma LBP-binding protein (LBP), membrane bound or soluble forms of CD14 and integrins
745093
Crassostrea gigas
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 15920, sequence calculation, x * 18000, SDS-PAGE
Debaryomyces hansenii
?
x * 37600
Lampanyctus crocodilus
?
x * 15800-16600 , two isozymes, sequence calculation, x * 18000, SDS-PAGE
Schwanniomyces vanrijiae var. vanrijiae
?
x * 30000, about, sequence calculation, x * 25000, recombinant enzyme, SDS-PAGE
Sonneratia alba
homodimer
2 * 40000
Porphyridium purpureum
homodimer
2 * 23000, SDS-PAGE
Ulva linza
monomer
1 * 50230, sequence calculation, 1 * 59000, SDS-PAGE
Geobacillus sp. EPT3
More
amino acid sequence comparisons, the swortfish SOD has a higher content of arginine and tyrosine than the corresponding bovine enzyme and appears to dissociate more readily into subunits. The swortfish enzyme has a higher content of arginine and tyrosine, high homology with the other eukaryotic enzymes,and low homology with the Photobacterium leiognuthi enzyme
Xiphias gladius
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Sonneratia alba
35
-
-
Ulva linza
Temperature Range [°C] (protein specific)
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
-
35
maximal enzyme activity at 35°C, and 29.8% relative activity at 0°C
Ulva linza
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
additional information
-
a highly thermostable enzyme, occurrence of an additional sulfur-containing hydrogen bond involving the M110 residue and the effect of the A138 residue on the backbone entropy
Alvinella pompejana
additional information
-
high thermostability
Gadus morhua
additional information
-
a higher thermostable enzyme
Lampanyctus crocodilus
additional information
-
a highly thermostable enzyme
Photobacterium leiognathi
additional information
-
a highly thermostable enzyme
Photobacterium sepia
additional information
-
a thermostable enzyme
Sonneratia alba
40
-
stable below
Ulva linza
50
-
highly thermostable at
Geobacillus sp. EPT3
65
-
purified enzyme, half-life is 110 min
Alvinella pompejana
80
-
purified enzyme, half-life is 9.8-20.8 min
Alvinella pompejana
100
-
purified enzyme, strong stability at pH 6.0-7.0, the enzyme survives boiling for 10 min without losing more than 60% of activity
Debaryomyces hansenii
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
3.5
9.5
stable at, 25°C
Sonneratia alba
4
12
stable at
Conticribra weissflogii
5
10
stable at
Ulva linza
5
11
quite stable at
Geobacillus sp. EPT3
6
7
purified enzyme, strong stability at pH 6.0-7.0, the enzyme survives boiling for 10 min without losing more than 60% of activity
Debaryomyces hansenii
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Prionace glauca
the enzyme has a low isoelectric point
-
additional information
Debaryomyces hansenii
two pI ranges: 5.14-4.0 and 1.6-1.8, isoelectric focusing
1.8
1.6
Debaryomyces hansenii
two pI ranges: 5.14-4.0 and 1.6-1.8, isoelectric focusing
5.14
4
Photobacterium sepia
-
-
4.1
Porphyridium purpureum
isoelectric focusing
-
4.2
Photobacterium leiognathi
-
-
4.4
Mytilus edulis
isozyme 3, isoelectric focusing
-
4.55
Mytilus edulis
isozyme 1, isoelectric focusing
-
4.6
Geobacillus sp. EPT3
-
-
4.65
Mytilus edulis
isozyme 2, isoelectric focusing
-
4.7
Lampanyctus crocodilus
-
-
6.35
Expression
Organism
Commentary
Expression
Avicennia marina
a decrease in mRNA levels is observed for Sod1 with osmotic stress treatment
down
Schwanniomyces vanrijiae var. vanrijiae
treatment with CuSO4 inhibits expression of SOD protein, addition of Mn2+ to the medium reduces the enzyme expressions
down
Tetraselmis subcordiformis
the enzyme is downregulated by UV-B radiation
down
Apostichopus japonicus
up-regulation of SOD mRNA with low salinity stress, increase levels of Sod mRNA by thermal and osmotic stresses
up
Avicennia marina
Sod1 mRNA levels are induced by iron, light stress and by direct H2O2stress treatment, thus confirming their role in oxidative stress response
up
Bruguiera gymnorhiza
NaCl treatment increases the transcript level of cytosolic Cu/Zn-SOD in young and mature leaves rather than in old leaves. Expression of the cytosolic Cu/Zn-SOD gene is induced by exogenous abscisic acid
up
Haliotis discus discus
the mRNA levels of Cu/Zn-SOD is increased in general during the metal (copper, zinc and cadmium) or thermal treatments; the mRNA levels of Mn-SOD is increased in general during the metal (copper, zinc and cadmium) or thermal treatments
up
Lingulodinium polyedra
the enzyme Fe-SOD is induced after exposure to toxic metal ions
up
Nodularia sp. (in: Bacteria)
UV-irradiation induces the enzyme
up
Penaeus vannamei
infection of the organism by white spot syndrome virus increases the expression of cMn-SOD. Transcript levels increase transiently 1 h post-infection and then decrease as the viral infection progresses to levels significantly lower than uninfected controls by 12 h post-infection
up
Pinctada fucata
after challenge with lipopolysaccharide (LPS), expression of pfSOD mRNA in hemocytes is increased, reaching the highest level at 8 h, then dropping to basal levels at 36 h
up
Schwanniomyces vanrijiae var. vanrijiae
enzyme expression is increased when cells are cultured with Cu2+, Cr2+, Fe3+ and Ni2+
up
Tetraselmis gracilis
the enzyme is induced by Cd2+
up
General Information
General Information
Commentary
Organism
evolution
the two different allelic forms of a Mn-SOD involved in ROS detoxification, ApMn-SOD1 and ApMn-SOD2, differ only by two substitutions, M110L and A138G, identified in an Alvinella pompejana cDNA library; the two different allelic forms of a Mn-SOD involved in ROS detoxification, ApMn-SOD1 and ApMn-SOD2, differ only by two substitutions, M110L and A138G, identified in an Alvinella pompejana cDNA library. ApMn-SOD2 is rare (2%) and only found in the heterozygous state
Alvinella pompejana
evolution
phylogenetic analysis clusters cMn-SODs and mitochondrial Mn-SODs in two separate groups
Penaeus vannamei
additional information
histidine and tryptophan residues are involved in the catalytic activity
Geobacillus sp. EPT3
additional information
blue mussels from chemically contaminated area in Le Havre harbor exhibited a third Cu/Zn-SOD isoform characterized by a more acidic isoelectric point (pI 4.55) and a native apparent molecular mass of 130 kDa. When maintained in clean marine water, mussels from this area showed a transitory decrease in total SOD activity accompanied by the disappearance of the SOD-3 band
Mytilus edulis
additional information
histidine and tryptophan residues are involved in the catalytic activity
Photobacterium leiognathi
additional information
ElSOD as a cold-adapted enzyme
Ulva linza
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes. The organism is exposed to various challenging conditions (e.g. high temperature, hypoxia and the presence of sulphides, heavy metals and radiations), which increase the production of dangerous reactive oxygen species (ROS). Two different allelic forms of a Mn-SOD involved in reactive oxygen species detoxification, ApMn-SOD1 and ApMn-SOD2
Alvinella pompejana
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Apostichopus japonicus
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Avicennia marina
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Bruguiera gymnorhiza
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Cliona celata
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Conticribra weissflogii
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Crassostrea gigas
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Cylindrotheca closterium
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Debaryomyces hansenii
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Gadus morhua
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Geobacillus sp. EPT3
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Haliotis discus discus
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Lampanyctus crocodilus
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Lingulodinium polyedra
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes. The enzyme plays an important role in preventing oxidative stress triggered by a number of factors that affect growth, such as nutrient and light availability
Minutocellus polymorphus
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Mytilus edulis
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes. An increase in the Fe-SOD content, particularly evident in scum samples that are continuously exposed to high irradiances, may have a role in the photo adaptation of diazotrophic cyanobacteria and help to protect them from light injury in the Baltic Sea
Nodularia sp. (in: Bacteria)
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Penaeus vannamei
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Photobacterium leiognathi
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Photobacterium sepia
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Pinctada fucata
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Porphyridium purpureum
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Prionace glauca
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Schwanniomyces vanrijiae var. vanrijiae
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Sonneratia alba
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes; the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Sparus aurata
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes. The enzyme of Tetraselmis gracilis is important to prevent oxidative stress such as nutrient and light availability
Tetraselmis gracilis
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Tetraselmis subcordiformis
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes. ElSOD is a cold-adapted SOD, which shows its potential valuein antioxidant utilization
Ulva linza
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Xiphias gladius
General Information (protein specific)
General Information
Commentary
Organism
evolution
the two different allelic forms of a Mn-SOD involved in ROS detoxification, ApMn-SOD1 and ApMn-SOD2, differ only by two substitutions, M110L and A138G, identified in an Alvinella pompejana cDNA library; the two different allelic forms of a Mn-SOD involved in ROS detoxification, ApMn-SOD1 and ApMn-SOD2, differ only by two substitutions, M110L and A138G, identified in an Alvinella pompejana cDNA library. ApMn-SOD2 is rare (2%) and only found in the heterozygous state
Alvinella pompejana
evolution
phylogenetic analysis clusters cMn-SODs and mitochondrial Mn-SODs in two separate groups
Penaeus vannamei
additional information
histidine and tryptophan residues are involved in the catalytic activity
Geobacillus sp. EPT3
additional information
blue mussels from chemically contaminated area in Le Havre harbor exhibited a third Cu/Zn-SOD isoform characterized by a more acidic isoelectric point (pI 4.55) and a native apparent molecular mass of 130 kDa. When maintained in clean marine water, mussels from this area showed a transitory decrease in total SOD activity accompanied by the disappearance of the SOD-3 band
Mytilus edulis
additional information
histidine and tryptophan residues are involved in the catalytic activity
Photobacterium leiognathi
additional information
ElSOD as a cold-adapted enzyme
Ulva linza
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes. The organism is exposed to various challenging conditions (e.g. high temperature, hypoxia and the presence of sulphides, heavy metals and radiations), which increase the production of dangerous reactive oxygen species (ROS). Two different allelic forms of a Mn-SOD involved in reactive oxygen species detoxification, ApMn-SOD1 and ApMn-SOD2
Alvinella pompejana
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Apostichopus japonicus
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Avicennia marina
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Bruguiera gymnorhiza
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Cliona celata
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Conticribra weissflogii
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Crassostrea gigas
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Cylindrotheca closterium
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Debaryomyces hansenii
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Gadus morhua
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Geobacillus sp. EPT3
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Haliotis discus discus
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Lampanyctus crocodilus
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Lingulodinium polyedra
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes. The enzyme plays an important role in preventing oxidative stress triggered by a number of factors that affect growth, such as nutrient and light availability
Minutocellus polymorphus
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Mytilus edulis
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes. An increase in the Fe-SOD content, particularly evident in scum samples that are continuously exposed to high irradiances, may have a role in the photo adaptation of diazotrophic cyanobacteria and help to protect them from light injury in the Baltic Sea
Nodularia sp. (in: Bacteria)
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Penaeus vannamei
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Photobacterium leiognathi
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Photobacterium sepia
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Pinctada fucata
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Porphyridium purpureum
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Prionace glauca
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Schwanniomyces vanrijiae var. vanrijiae
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Sonneratia alba
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Sparus aurata
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes. The enzyme of Tetraselmis gracilis is important to prevent oxidative stress such as nutrient and light availability
Tetraselmis gracilis
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Tetraselmis subcordiformis
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes. ElSOD is a cold-adapted SOD, which shows its potential valuein antioxidant utilization
Ulva linza
physiological function
the ability of marine organism to cope with oxidative stress is one of the main factors that influence its survival in the marine environment, when senescence conditions prevail. The antioxidative defense system includes enzymatic and non-enzymatic components. Among the enzymatic system, superoxide dismutases are the first and most important of the antioxidant metalloenzymes
Xiphias gladius
Expression (protein specific)
Organism
Commentary
Expression
Avicennia marina
a decrease in mRNA levels is observed for Sod1 with osmotic stress treatment
down
Schwanniomyces vanrijiae var. vanrijiae
treatment with CuSO4 inhibits expression of SOD protein, addition of Mn2+ to the medium reduces the enzyme expressions
down
Tetraselmis subcordiformis
the enzyme is downregulated by UV-B radiation
down
Apostichopus japonicus
up-regulation of SOD mRNA with low salinity stress, increase levels of Sod mRNA by thermal and osmotic stresses
up
Avicennia marina
Sod1 mRNA levels are induced by iron, light stress and by direct H2O2stress treatment, thus confirming their role in oxidative stress response
up
Bruguiera gymnorhiza
NaCl treatment increases the transcript level of cytosolic Cu/Zn-SOD in young and mature leaves rather than in old leaves. Expression of the cytosolic Cu/Zn-SOD gene is induced by exogenous abscisic acid
up
Haliotis discus discus
the mRNA levels of Cu/Zn-SOD is increased in general during the metal (copper, zinc and cadmium) or thermal treatments; the mRNA levels of Mn-SOD is increased in general during the metal (copper, zinc and cadmium) or thermal treatments
up
Lingulodinium polyedra
the enzyme Fe-SOD is induced after exposure to toxic metal ions
up
Nodularia sp. (in: Bacteria)
UV-irradiation induces the enzyme
up
Penaeus vannamei
infection of the organism by white spot syndrome virus increases the expression of cMn-SOD. Transcript levels increase transiently 1 h post-infection and then decrease as the viral infection progresses to levels significantly lower than uninfected controls by 12 h post-infection
up
Pinctada fucata
after challenge with lipopolysaccharide (LPS), expression of pfSOD mRNA in hemocytes is increased, reaching the highest level at 8 h, then dropping to basal levels at 36 h
up
Schwanniomyces vanrijiae var. vanrijiae
enzyme expression is increased when cells are cultured with Cu2+, Cr2+, Fe3+ and Ni2+
up
Tetraselmis gracilis
the enzyme is induced by Cd2+
up
Other publictions for EC 1.15.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744564
Li
-
Engineering a highly thermost ...
Aeropyrum pernix
Biotechnol. Bioprocess Eng.
22
725-733
2017
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1
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1
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4
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3
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2
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2
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2
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4
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1
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2
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2
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2
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2
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1
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1
1
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744962
Call
Muscle-derived extracellular ...
Mus musculus, Mus musculus C57BL/6J
Free Radic. Biol. Med.
113
212-223
2017
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1
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1
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1
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6
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2
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2
2
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745088
Zeinali
Identification and kinetic ch ...
Avicennia marina
Int. J. Biol. Macromol.
105
1556-1562
2017
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-
-
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2
2
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2
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1
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1
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1
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1
1
1
1
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745228
Kan
Cloning and characterization ...
Rhodotorula mucilaginosa, Rhodotorula mucilaginosa AN5
J. Basic Microbiol.
57
680-690
2017
-
-
1
-
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9
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5
1
2
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6
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1
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4
1
1
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4
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1
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1
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9
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5
1
2
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4
1
1
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4
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1
1
1
1
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2
2
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745653
Azadmanesh
Substrate-analog binding and ...
Homo sapiens
J. Struct. Biol.
199
68-75
2017
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1
1
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737269
Li
Improving the thermostability ...
Geobacillus thermodenitrificans, Geobacillus thermodenitrificans NG80-2, Saccharolobus solfataricus, Saccharolobus solfataricus DSM 1617
Springerplus
5
241
2016
-
-
-
-
2
-
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-
-
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9
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2
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2
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1
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2
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2
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-
-
-
-
-
2
-
2
-
1
-
2
-
-
-
-
-
-
-
744281
Wang
Gene expression characteristi ...
Arabidopsis thaliana, Glycine max, Gypsophila oblanceolata, Nicotiana benthamiana, Nicotiana plumbaginifolia, Nicotiana tabacum, Nostoc sp. PCC 7120, Pleurotus ostreatus, Populus trichocarpa, Pseudomonas putida, Raphanus sativus var. raphanistroides, Rattus norvegicus, Rhodobacter capsulatus, Zea mays
Biochemistry (Moscow)
81
465-480
2016
-
-
2
-
-
-
-
-
11
19
-
19
-
20
-
13
-
-
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7
-
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19
-
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-
-
-
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-
-
-
-
-
2
-
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-
-
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12
21
-
19
-
-
18
-
-
7
-
-
19
-
-
-
-
-
-
-
-
-
26
28
38
32
-
-
744948
Li
Molecular characterization of ...
Portunus trituberculatus
Fish Shellfish Immunol.
52
263-277
2016
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
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1
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-
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-
-
-
-
-
-
-
-
2
-
-
2
-
-
745015
Abrashev
Production, purification, and ...
Aspergillus glaucus, Aspergillus glaucus 363/NBIMCC 8861
Fungal Biol.
120
679-689
2016
-
-
1
-
-
-
-
-
-
3
-
4
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7
-
2
1
-
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1
2
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4
1
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1
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-
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2
-
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-
-
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6
-
4
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2
2
-
2
2
-
4
2
-
-
2
-
-
-
-
-
-
2
4
-
-
-
745226
Wang
Cloning, expression and bioch ...
Pseudoalteromonas sp. ANT506
J. Basic Microbiol.
56
753-761
2016
-
-
1
-
-
-
6
-
-
6
-
1
-
4
-
-
1
-
-
-
-
-
1
1
1
1
3
-
1
-
1
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-
1
-
-
-
1
-
-
-
-
-
6
-
-
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6
-
1
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1
-
-
-
-
1
1
1
1
3
-
1
-
1
1
-
-
-
-
-
-
745774
Shrestha
Cloning, purification, and ch ...
Homo sapiens
Mol. Cells
39
242-249
2016
-
1
1
-
1
-
1
-
1
2
-
1
-
2
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1
1
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2
3
1
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1
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1
1
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1
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1
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1
2
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1
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1
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2
3
1
-
-
-
1
-
-
-
-
-
-
-
-
-
746336
Kumar
-
Copper, zinc superoxide dismu ...
Caragana jubata
Process Biochem.
51
1434-1444
2016
-
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1
-
-
-
3
-
1
2
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1
-
1
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1
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1
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2
3
1
1
3
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1
1
1
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1
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1
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-
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3
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1
2
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1
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1
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1
-
2
3
1
1
3
-
1
1
1
1
-
-
-
-
-
-
746337
Li
-
Engineering a thermostable ir ...
Thermus thermophilus
Process Biochem.
51
39-47
2016
-
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1
-
4
-
-
-
-
3
-
1
-
1
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1
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1
2
1
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3
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1
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2
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1
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1
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4
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3
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1
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1
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1
2
1
-
3
-
1
-
2
1
-
1
1
-
-
-
749377
Soares
-
Assessment of stress-related ...
Jatropha curcas
South Afr. J. Bot.
105
163-168
2016
-
-
-
-
-
-
-
-
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1
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1
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1
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1
-
-
-
-
-
-
-
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1
-
-
-
1
-
-
1
-
-
730066
Pinto
Superoxide reduction by a supe ...
Ignicoccus hospitalis
J. Biol. Inorg. Chem.
20
155-164
2015
-
-
1
-
1
-
-
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1
1
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1
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1
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1
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1
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1
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1
1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
744065
Rojas-Contreras
Expression and characterizati ...
Deschampsia antarctica
Appl. Biochem. Biotechnol.
175
3287-3296
2015
-
1
1
-
-
-
2
1
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2
-
1
-
4
-
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1
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-
-
1
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2
1
1
2
4
-
1
1
-
-
-
-
-
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1
1
-
-
-
-
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2
-
1
-
2
-
1
-
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1
-
-
1
-
2
1
1
2
4
-
1
1
-
-
-
1
1
-
-
-
744066
Montero-Moran
Biochemical and molecular cha ...
Amaranthus hypochondriacus
Appl. Biochem. Biotechnol.
176
2328-2345
2015
-
-
1
-
-
-
2
-
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3
1
1
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3
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1
-
-
2
-
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1
2
1
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-
1
-
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-
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1
-
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1
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2
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3
1
1
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1
-
2
-
-
1
2
1
-
-
-
1
-
-
1
-
-
-
-
-
-
744591
Tuteja
Heterologous expression and b ...
Pisum sativum
BMC Biotechnol.
15
3-3
2015
-
-
1
-
1
1
4
-
2
3
1
1
-
2
-
-
1
-
-
-
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1
2
2
1
-
3
-
1
2
1
-
-
-
-
-
-
1
-
-
1
1
-
4
-
-
2
3
1
1
-
-
-
1
-
-
-
1
2
2
1
-
3
-
1
2
1
-
-
1
1
-
-
-
744601
Brennan
Cloning, expression, and char ...
Coxiella burnetii
BMC Microbiol.
15
99
2015
-
-
1
-
-
-
2
-
2
2
-
1
-
4
-
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1
-
-
-
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1
1
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1
-
-
-
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1
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-
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2
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2
2
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1
-
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1
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
1
1
-
-
-
745093
Zeinali
Sources of marine superoxide ...
Alvinella pompejana, Apostichopus japonicus, Avicennia marina, Bruguiera gymnorhiza, Cliona celata, Conticribra weissflogii, Crassostrea gigas, Cylindrotheca closterium, Debaryomyces hansenii, Gadus morhua, Geobacillus sp. EPT3, Haliotis discus discus, Lampanyctus crocodilus, Lingulodinium polyedra, Minutocellus polymorphus, Mytilus edulis, Nodularia sp. (in: Bacteria), Penaeus vannamei, Photobacterium leiognathi, Photobacterium sepia, Pinctada fucata, Porphyridium purpureum, Prionace glauca, Schwanniomyces vanrijiae var. vanrijiae 020, Schwanniomyces vanrijiae var. vanrijiae, Sonneratia alba, Sparus aurata, Tetraselmis gracilis, Tetraselmis subcordiformis, Ulva linza, Xiphias gladius
Int. J. Biol. Macromol.
79
627-637
2015
-
3
8
-
1
1
8
-
9
33
5
32
-
34
-
-
6
-
-
24
1
-
33
8
2
1
11
-
-
-
5
-
-
11
-
-
3
8
-
-
1
1
-
9
-
-
9
33
5
32
-
-
-
7
-
24
1
-
33
8
2
1
11
-
-
-
5
11
13
36
37
13
-
-
745116
Yang
Cloning, characterization and ...
Sonneratia alba
Int. J. Mol. Sci.
17
E4
2015
3
-
1
-
-
-
6
-
1
2
-
1
3
4
-
1
1
-
-
5
1
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1
1
1
1
1
-
1
1
1
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-
1
-
3
-
1
-
-
-
-
-
6
-
-
1
2
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1
3
-
1
1
-
5
1
-
1
1
1
1
1
-
1
1
1
1
2
-
-
2
-
-
745137
Liu
Purification of Cu/Zn superox ...
Piper betle
J. Agric. Food Chem.
63
2225-2232
2015
-
-
-
-
-
-
-
-
-
2
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1
-
4
-
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1
-
-
3
-
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1
3
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-
-
-
1
-
-
-
-
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-
-
-
-
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-
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2
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1
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1
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3
-
-
1
3
-
-
-
-
1
-
-
-
-
1
1
-
-
-
745523
Zhang
Tertiary amine pyrazolones an ...
Homo sapiens, Mus musculus
J. Med. Chem.
58
5942-5949
2015
-
-
-
-
1
-
34
-
-
-
-
2
-
3
-
-
-
-
-
7
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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34
-
-
-
-
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2
-
-
-
-
-
7
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
745763
Ramasarma
New insights of superoxide di ...
Bos taurus
Mol. Cell. Biochem.
400
277-285
2015
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
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2
-
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2
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1
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1
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-
-
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-
-
-
-
-
-
-
-
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1
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-
-
2
-
-
2
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
746055
Zeng
Molecular cloning and charact ...
Miscanthus x giganteus
Plant Cell Rep.
34
2137-2149
2015
-
-
1
-
-
-
-
-
1
2
-
2
-
6
-
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1
-
-
8
1
-
3
1
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
2
-
2
-
-
-
2
-
16
1
-
3
1
-
-
1
-
-
-
-
-
-
2
3
-
-
-
727097
Haikarainen
Crystal structure and biochemi ...
Chaetomium thermophilum
Biochim. Biophys. Acta
1844
422-429
2014
-
-
1
1
-
-
-
-
-
1
1
1
-
5
-
-
1
-
-
-
-
-
1
2
1
-
5
-
-
-
-
-
-
-
-
-
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1
-
1
-
-
-
-
-
-
-
1
1
1
-
-
-
1
-
-
-
-
1
2
1
-
5
-
-
-
-
-
-
1
1
-
-
-
727297
Li
Probing the metal specificity ...
Clostridioides difficile
Chem. Commun. (Camb. )
50
584-586
2014
-
-
-
-
-
-
-
-
-
6
-
1
-
3
-
-
-
-
-
-
2
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1
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
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-
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-
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6
-
1
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
727446
Nonaka
Biochemical characterization o ...
Exiguobacterium sp., Exiguobacterium sp. OS-77
Extremophiles
18
363-373
2014
-
-
1
-
-
-
-
-
-
1
3
-
-
6
-
-
1
-
-
1
1
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-
1
1
1
3
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
3
-
-
-
-
1
-
1
1
-
-
1
1
1
3
-
1
1
-
-
-
2
2
-
-
-
744390
Smolik
Characterization of E. coli m ...
Escherichia coli
Biochim. Biophys. Acta
1844
2251-2256
2014
-
-
-
-
-
-
-
1
1
1
-
1
-
2
-
-
-
-
-
1
-
-
2
1
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
-
1
-
-
-
-
-
1
-
-
2
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
744464
Ben Khaled
-
A heat-stable Cu/Zn superoxid ...
Sardinella aurita
Biologia (Poland)
69
1770-1776
2014
-
-
-
-
-
-
2
-
-
2
1
1
-
1
-
-
1
-
-
-
1
-
2
2
1
1
3
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
2
1
1
-
-
-
1
-
-
1
-
2
2
1
1
3
-
1
1
1
-
-
1
1
-
-
-
744500
Lukas
Discovery of 1,3,4-oxidiazole ...
Mus musculus
Bioorg. Med. Chem. Lett.
24
1532-1537
2014
-
-
-
-
1
-
1
-
-
2
-
1
-
1
-
-
-
-
-
2
-
-
1
-
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-
-
-
-
-
-
-
-
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-
-
1
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1
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-
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2
-
1
-
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-
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2
-
-
1
-
-
-
-
-
-
-
-
-
2
1
1
2
-
-
744746
Umasuthan
Characterization of rock brea ...
Oplegnathus fasciatus
Comp. Biochem. Physiol. B
176
18-33
2014
-
-
1
-
-
-
4
-
2
2
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1
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4
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1
1
-
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11
-
-
1
1
1
-
2
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
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2
2
-
1
-
-
1
1
-
11
-
-
1
1
1
-
2
-
1
1
-
-
2
3
3
2
-
-
744963
Longoni
Excreted Leishmania peruviana ...
Leishmania amazonensis, Leishmania amazonensis MHOM/BR/73/M1845, Leishmania peruviana, Leishmania peruviana MHOM/PE/84/LC26
Free Radic. Biol. Med.
69
26-34
2014
-
-
-
-
-
-
-
-
2
2
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4
-
9
-
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2
-
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2
2
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4
2
-
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
-
-
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2
2
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4
-
-
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2
-
2
2
-
4
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
745059
Rasheed
Biochemical and immunological ...
Homo sapiens
Immunol. Lett.
160
50-57
2014
-
-
-
-
-
-
1
-
-
2
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1
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2
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-
-
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2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
1
-
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2
-
1
-
-
-
-
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2
-
-
2
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3
3
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746277
Niyomploy
A superoxide dismutase purifi ...
Stemona tuberosa
Prep. Biochem. Biotechnol.
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663-679
2014
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7
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1
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4
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7
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3
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1
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1
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1
1
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2
1
1
-
4
-
1
-
1
-
-
2
2
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746334
Kumar
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Copper, zinc superoxide dismu ...
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Process Biochem.
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2014
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1
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5
1
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1
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1
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5
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1
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1
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1
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1
1
-
1
1
1
1
2
-
1
1
1
-
-
-
-
-
-
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746551
Zhu
Cloning and characterization ...
Geobacillus sp. EPT3
World J. Microbiol. Biotechnol.
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2014
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1
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9
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2
1
1
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3
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1
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1
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1
1
1
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2
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1
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1
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1
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9
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2
1
1
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1
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1
-
1
1
1
-
2
-
1
-
1
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-
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-
746564
Gu
The superoxide dismutase from ...
Cherax quadricarinatus
Zool. Sci.
31
725-734
2014
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1
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3
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12
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1
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2
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4
3
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2
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-
20
-
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2
1
-
-
-
-
-
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1
2
1
2
3
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727206
Ou-Yang
Cloning, overexpression, purif ...
Jatropha curcas
Biotechnol. Appl. Biochem.
59
338-345
2013
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1
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4
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6
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3
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1
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1
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1
1
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3
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1
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1
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1
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4
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2
6
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1
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1
-
-
1
1
-
3
-
1
-
1
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-
-
-
-
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727563
Anju
Molecular cloning, characteriz ...
Pinctada fucata
Fish Shellfish Immunol.
34
946-950
2013
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1
1
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2
2
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2
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8
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1
1
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2
2
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8
-
-
-
-
-
-
-
-
-
-
-
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1
1
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728225
Mandelli
The characterization of a ther ...
Thermus filiformis, Thermus filiformis ATCC 43280
Lett. Appl. Microbiol.
57
40-46
2013
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1
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4
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1
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1
1
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1
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1
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1
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2
1
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1
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1
1
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1
-
1
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-
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1
1
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728606
Dhar
Detection, distribution and ch ...
Yersinia enterocolitica, Yersinia enterocolitica IP27366
PLoS ONE
8
e63919
2013
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1
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3
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3
3
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8
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2
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3
1
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2
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2
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3
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6
-
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3
8
3
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2
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4
2
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-
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2
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2
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1
3
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728648
Niyomploy
A superoxide dismutase purifie ...
Stemona tuberosa
Prep. Biochem. Biotechnol.
12
663-679
2013
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8
1
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5
2
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1
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1
1
1
4
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1
1
3
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8
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1
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5
2
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1
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1
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1
1
1
4
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1
1
3
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1
1
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728752
Wang
Cloning, expression, and chara ...
Sonneratia alba
Protein J.
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2013
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7
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1
1
1
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1
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1
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1
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1
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1
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-
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1
1
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1
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7
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1
1
1
-
1
-
1
-
1
1
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-
-
-
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-
728784
Guzman-Deara
Identification and characteriz ...
Phytophthora cinnamomi
Protoplasma
250
779-785
2013
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-
-
-
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3
-
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2
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3
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1
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1
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1
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3
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2
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1
-
-
-
-
1
-
-
-
1
-
-
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-
1
1
-
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728785
Orzolek
Superoxide dismutase (SOD) in ...
Sus scrofa
Reprod. Biol.
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34-40
2013
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4
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2
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1
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2
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1
1
1
2
1
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1
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4
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2
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1
-
2
-
1
1
1
2
1
-
-
1
-
-
-
-
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-
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728846
Zhu
Cloning and characterization o ...
Geobacillus sp.
World J. Microbiol. Biotechnol.
30
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2013
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19
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2
3
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3
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1
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1
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2
1
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3
-
1
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1
-
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1
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1
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-
-
-
-
19
-
-
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2
3
-
-
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1
-
-
1
-
-
2
1
-
3
-
1
-
1
1
-
1
1
-
-
-
728847
Chao
Cloning, expression, and purif ...
Jatropha curcas
Z. Naturforsch. C
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60-69
2013
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1
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6
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2
3
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3
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1
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-
1
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1
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2
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5
-
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1
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6
-
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2
3
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1
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-
1
-
-
1
-
-
2
-
-
-
-
5
-
-
-
-
-
-
726922
Slutskaya
Iron-dependent superoxide dism ...
Acidilobus saccharovorans
Biochemistry (Moscow)
77
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2012
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1
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-
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2
2
1
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2
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1
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1
1
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2
2
2
1
6
-
1
1
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1
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-
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2
2
1
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1
-
1
1
-
2
2
2
1
6
-
1
1
-
-
-
1
1
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727588
Mahanty
Biochemical and molecular anal ...
Cenchrus americanus
Gene
505
309-317
2012
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1
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2
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1
2
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9
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1
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1
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1
1
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2
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1
1
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1
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1
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2
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1
2
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-
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1
-
1
-
-
1
1
-
-
2
-
1
1
-
1
1
2
2
1
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728111
Cho
Expression and characterizatio ...
Burkholderia pseudomallei 1106a, Burkholderia pseudomallei
J. Microbiol.
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1029-1033
2012
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1
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3
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5
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1
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-
-
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2
1
1
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4
-
1
1
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-
-
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1
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3
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1
1
2
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1
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-
-
-
2
1
1
-
4
-
1
1
-
-
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-
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728279
Gao
Intracellular Cu/Zn superoxide ...
Meretrix meretrix
Mol. Biol. Rep.
39
10713-10722
2012
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1
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2
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3
1
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1
1
1
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2
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1
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2
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-
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1
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-
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2
2
1
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-
-
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1
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3
1
-
1
1
1
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2
-
1
-
2
-
1
2
2
1
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714576
Zhang
Expression of a novel thermost ...
Chaetomium thermophilum, Chaetomium thermophilum HSAUP072651
Biotechnol. Lett.
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1127-1132
2011
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1
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1
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1
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3
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1
1
1
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-
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1
1
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3
-
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2
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1
-
-
1
-
-
-
1
-
3
-
1
1
1
-
-
-
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-
-
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714772
Wang
Purification, molecular clonin ...
Paralichthys olivaceus
Comp. Biochem. Physiol. B
158
289-296
2011
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1
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-
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1
1
2
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2
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1
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1
1
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-
1
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-
-
-
-
-
-
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-
-
1
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-
-
-
-
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1
1
2
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-
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1
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714882
Wawrzykowski
-
Changes in activity during sto ...
Gallus gallus
Eur. Food Res. Technol.
232
479-484
2011
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-
-
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-
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1
2
1
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4
1
2
1
1
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
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1
2
1
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4
1
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714933
Liu
Purification and characterizat ...
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
Extremophiles
15
221-226
2011
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1
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-
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6
-
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4
1
2
-
25
-
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1
-
-
-
1
-
2
2
1
1
3
-
1
1
-
-
-
1
-
-
-
1
-
-
-
-
-
6
-
-
-
4
1
2
-
-
-
1
-
-
1
-
2
2
1
1
3
-
1
1
-
1
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-
-
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714989
Nakamura
Crystal structure of the cambi ...
Aeropyrum pernix
FEBS J.
278
598-609
2011
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1
1
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6
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5
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2
2
1
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1
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-
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-
-
-
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1
-
1
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-
-
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2
2
1
-
-
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-
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5
-
2
2
1
-
1
-
-
-
-
-
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1
1
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715089
Inarrea
Melatonin and steroid hormones ...
Rattus norvegicus, Rattus norvegicus Wistar
Free Radic. Biol. Med.
50
1575-1581
2011
6
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-
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7
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2
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166
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
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7
-
-
2
2
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
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716572
Wu
Characterization of copper/zin ...
Bambusa oldhamii
Plant Physiol. Biochem.
49
195-200
2011
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1
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2
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3
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3
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1
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2
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2
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-
-
-
-
-
-
-
-
-
-
-
-
-
2
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-
-
-
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2
-
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3
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-
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2
-
4
-
2
-
-
-
-
-
-
-
-
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1
2
2
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727224
Madanala
A highly stable Cu/Zn superoxi ...
Withania somnifera
Biotechnol. Lett.
33
2057-2063
2011
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1
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1
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3
3
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1
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-
1
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1
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-
3
-
-
-
1
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
3
3
3
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-
-
3
1
-
-
1
-
-
1
-
-
3
-
-
-
1
1
-
-
-
-
-
-
727572
Testa
The superoxide reductase from ...
no activity in Giardia intestinalis
Free Radic. Biol. Med.
51
1567-1574
2011
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-
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-
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6
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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727613
Asthir
Kinetic properties of cell wal ...
Triticum aestivum
Indian J. Biochem. Biophys.
48
341-345
2011
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-
-
-
-
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3
1
2
5
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3
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
2
5
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
727639
Areekit
Cloning, expression, and chara ...
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) MHS47
Int. J. Mol. Sci.
12
844-856
2011
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1
1
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-
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2
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1
1
2
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7
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1
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1
-
2
1
1
1
1
-
1
1
-
-
-
1
-
-
1
1
-
-
-
-
-
2
-
-
-
1
1
2
-
-
-
1
-
-
1
-
2
1
1
1
1
-
1
1
-
1
-
2
2
-
-
-
727892
Colinet
Extracellular superoxide dismu ...
Leptopilina boulardi, Leptopilina heterotoma
J. Biol. Chem.
286
40110-40121
2011
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2
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2
4
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11
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-
-
-
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5
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
8
-
-
-
-
-
-
-
9
-
-
-
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4
-
-
-
4
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-
2
4
-
-
-
728102
Lee
An efficient method for the ex ...
Aeropyrum pernix, Aeropyrum pernix DSM 11879
J. Microbiol. Biotechnol.
20
727-731
2011
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-
1
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2
2
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5
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1
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2
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1
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-
728110
Nam
Molecular cloning, purificatio ...
Mycobacterium sp., Mycobacterium sp. DSM 3803
J. Microbiol.
49
399-406
2011
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-
1
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3
-
2
2
3
-
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4
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1
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1
1
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1
1
1
3
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1
1
1
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1
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1
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3
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2
2
3
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1
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1
1
-
-
1
1
1
3
-
1
1
1
1
-
-
-
-
-
-
713628
Wakadkar
Expression, purification and c ...
Chaetomium thermophilum
Acta Crystallogr. Sect. F
66
1089-1092
2010
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-
1
1
-
-
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2
1
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3
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1
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1
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1
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1
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1
-
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1
1
-
1
-
1
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-
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-
-
-
-
-
-
713650
Gazdag
Purification and crystallizati ...
Homo sapiens
Acta Crystallogr. Sect. F
66
871-877
2010
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1
1
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2
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713971
Jevremovic
-
Superoxide dismutase activity ...
Fritillaria meleagris
Arch. Biol. Sci.
62
553-558
2010
-
-
-
-
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3
2
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1
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1
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1
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1
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-
1
-
-
1
-
-
714399
Li
Purification and characterizat ...
Panax ginseng
Biomed. Chromatogr.
24
1203-1207
2010
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3
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1
2
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2
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1
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1
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1
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1
2
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1
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1
1
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1
1
-
3
-
1
-
1
-
-
-
-
-
-
-
714572
Wu
Improvement of the CuZn-supero ...
Sus scrofa
Biotechnol. Lett.
32
1939-1945
2010
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-
-
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1
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1
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2
1
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2
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1
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1
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1
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1
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1
1
-
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1
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-
-
1
-
-
-
-
-
-
-
714855
Xie
-
Characterization of a new Cu/Z ...
Beauveria bassiana, Beauveria bassiana 2860
Enzyme Microb. Technol.
46
217-222
2010
-
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1
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2
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2
1
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2
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1
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1
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3
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1
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-
715065
Xu
Molecular cloning, identificat ...
Cristaria plicata
Fish Shellfish Immunol.
29
615-622
2010
-
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1
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1
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2
2
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5
-
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1
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1
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2
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1
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-
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1
-
1
1
-
-
-
2
2
-
-
-
715260
Barnese
Investigation of the highly ac ...
Saccharomyces cerevisiae
J. Am. Chem. Soc.
132
12525-12527
2010
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-
-
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1
1
1
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1
-
8
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1
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1
1
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1
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1
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1
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1
1
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-
-
-
-
-
-
-
1
1
-
-
-
715677
Isarankura-Na-Ayudhya
Engineering of a novel chimera ...
Homo sapiens
J. Biosci. Bioeng.
110
633-637
2010
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1
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1
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1
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1
4
1
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3
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1
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2
1
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1
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1
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1
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1
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4
1
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1
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1
2
1
-
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-
1
-
-
-
-
1
1
-
-
-
716187
De Vendittis
Regulation of the properties o ...
Streptococcus mutans, Streptococcus mutans UA159
Mol. Biosyst.
6
1973-1982
2010
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1
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1
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3
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19
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1
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1
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1
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1
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-
1
-
1
-
1
-
-
-
-
1
1
-
-
-
716197
McAtee
Manganese superoxide dismutase ...
Homo sapiens
Mol. Cell. Biochem.
335
107-118
2010
-
-
1
-
1
-
-
-
1
1
-
1
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3
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11
-
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1
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1
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1
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1
1
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1
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11
-
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1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
716425
Li
Functional expression and char ...
Spirometra erinaceieuropaei
Parasitol. Res.
106
627-635
2010
-
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1
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3
-
2
2
3
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7
-
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1
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2
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1
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1
1
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1
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3
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2
2
3
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1
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2
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1
-
-
-
-
1
1
-
-
1
1
1
1
-
-
701534
Pedersen
The first structure of a cold- ...
Aliivibrio salmonicida
Acta Crystallogr. Sect. F
65
84-92
2009
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1
1
-
-
-
-
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1
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4
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1
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1
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1
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1
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1
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1
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-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
702175
Zhan
Preparation and characterizati ...
Bos taurus
Biochemistry (Moscow)
74
1266-1269
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
1
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1
1
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1
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1
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1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702845
Sfaxi
Inhibitory effects of a mangan ...
Allium sativum
Biotechnol. Prog.
25
257-264
2009
-
-
-
-
-
-
-
-
-
-
-
2
-
5
-
-
1
-
-
1
1
-
3
-
1
-
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-
1
-
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-
-
-
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-
-
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-
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2
-
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1
-
1
1
-
3
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
702926
Sanchez-Venegas
Molecular characterization of ...
Deschampsia antarctica
BMC Res. Notes
2
198
2009
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1
-
-
-
-
-
-
2
1
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-
2
-
-
-
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-
-
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1
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-
-
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1
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-
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1
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-
-
-
-
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-
2
1
-
-
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
703295
Marchand
Characterization and sequence ...
Bythograea thermydron, Cyanagraea praedator, Segonzacia mesatlantica
Comp. Biochem. Physiol. B
153
191-199
2009
-
-
3
-
-
-
-
-
6
3
-
-
-
15
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
6
6
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703644
Yao
Betulinic acid-mediated inhibi ...
Mus musculus
FEBS J.
276
2599-2614
2009
-
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
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-
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-
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-
-
-
-
-
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-
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1
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-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
703777
Bao
Cloning, characterization, and ...
Argopecten irradians
Fish Shellfish Immunol.
27
17-25
2009
-
-
1
-
-
-
-
-
1
2
-
-
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5
-
-
-
-
-
2
-
-
-
-
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-
-
-
-
-
-
-
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-
-
1
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-
-
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1
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
703778
Lin
Characterization, molecular mo ...
Danio rerio, Danio rerio AB
Fish Shellfish Immunol.
27
318-324
2009
-
-
1
-
-
1
-
-
-
1
1
2
-
5
-
-
1
-
-
1
-
-
2
2
-
-
4
-
-
1
-
-
-
1
-
-
-
1
-
-
-
1
-
-
-
-
-
1
1
2
-
-
-
1
-
1
-
-
2
2
-
-
4
-
-
1
-
1
-
-
-
-
-
-
703779
Park
Molecular cloning, characteriz ...
Laternula elliptica
Fish Shellfish Immunol.
27
522-528
2009
-
-
1
-
-
-
-
-
-
1
1
1
-
6
-
-
1
-
-
-
2
-
2
1
-
-
1
-
1
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
-
-
-
1
-
-
2
-
2
1
-
-
1
-
1
1
-
1
-
-
-
-
-
-
703780
Lin
Molecular cloning and characte ...
Penaeus japonicus
Fish Shellfish Immunol.
28
143-150
2009
-
-
1
-
-
-
-
-
6
1
2
-
-
6
-
-
-
-
-
5
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
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2
-
-
-
-
-
-
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-
6
2
2
-
-
-
-
-
-
10
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704820
Nedeva
Purification and partial chara ...
Kluyveromyces marxianus, Kluyveromyces marxianus NBIMCC 1984
J. Chromatogr. B
877
3529-3536
2009
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-
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8
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2
1
2
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6
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1
1
-
-
-
1
-
2
1
1
-
3
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
2
1
2
-
-
1
1
-
-
1
-
2
1
1
-
3
-
1
-
1
-
-
-
-
-
-
-
704979
Ghosh
Stabilization of Mn(II) and Mn ...
Homo sapiens
J. Inorg. Biochem.
104
9-18
2009
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-
-
-
-
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6
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1
-
1
-
1
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-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
4
6
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
705102
Song
Cloning, expression, and chara ...
Thermoascus aurantiacus
J. Microbiol.
47
123-130
2009
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1
-
-
-
2
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1
1
2
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4
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1
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-
1
1
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-
1
1
1
4
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
1
2
-
-
-
-
1
-
1
1
-
-
1
1
1
4
-
1
1
-
-
-
-
-
-
-
-
705133
Rumfeldt
Unfolding and folding kinetics ...
Homo sapiens
J. Mol. Biol.
385
278-298
2009
-
-
-
-
5
-
-
-
-
3
1
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-
3
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
3
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705805
Tuller
Docosahexaenoic acid inhibits ...
Homo sapiens
Mol. Pharmacol.
76
588-595
2009
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-
1
-
1
-
-
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1
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2
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1
-
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-
-
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-
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-
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-
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-
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1
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-
1
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1
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-
-
-
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
726264
Maaty
Something old, something new, ...
Saccharolobus solfataricus, Saccharolobus solfataricus P2
PLoS One
4
e6964
2009
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-
-
-
-
-
-
-
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1
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7
1
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
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-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
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684623
Raimondi
Characterization of the supero ...
Kluyveromyces marxianus, Kluyveromyces marxianus L3
Appl. Microbiol. Biotechnol.
77
1269-1277
2008
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1
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684757
Krumova
Unusual location and character ...
Humicola lutea 103, Humicola lutea
Arch. Microbiol.
189
121-130
2008
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684936
Secondo
The Cu-Zn superoxide dismutase ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
376
143-147
2008
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685211
Abreu
The kinetic mechanism of manga ...
Deinococcus radiodurans
Biochemistry
47
2350-2356
2008
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685382
Park
Presymptomatic biochemical cha ...
Homo sapiens
Biochim. Biophys. Acta
1782
462-468
2008
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685390
Esposito
The crystal structure of the s ...
Helicobacter pylori
Biochim. Biophys. Acta
1784
1601-1606
2008
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685849
Donate
Identification of biomarkers f ...
Mus musculus
Br. J. Cancer
98
776-783
2008
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1
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685851
Broeyer
The pharmacokinetics and effec ...
Homo sapiens
Br. J. Clin. Pharmacol.
65
22-29
2008
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1
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685900
Rezg
Biochemical evaluation of hepa ...
Rattus norvegicus
C. R. Biol.
331
655-662
2008
1
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1
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687265
Lai
Isolation and characterization ...
Triticum aestivum
J. Agric. Food Chem.
56
8121-8129
2008
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5
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1
2
1
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1
1
1
2
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1
1
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-
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687789
Gao
Extracellular superoxide dismu ...
Homo sapiens, Mus musculus
J. Biol. Chem.
283
6058-6066
2008
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5
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688168
Wang
Cloning and characterization o ...
Rhodothermus sp., Rhodothermus sp. XMH10
J. Ind. Microbiol. Biotechnol.
35
133-139
2008
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688736
Suzuki
Pharmacokinetics of PC-SOD, a ...
Homo sapiens
J. Clin. Pharmacol.
48
184-192
2008
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688914
Zhang
Cloning, characterization and ...
Haliotis diversicolor supertexta
Mol. Biol. Rep.
36
583-594
2008
1
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1
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689984
Dufernez
Molecular characterization of ...
Crypthecodinium cohnii
Protist
159
223-238
2008
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2
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6
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6
6
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690078
Dolashki
Biochemical properties of Cu/Z ...
Aspergillus niger, Aspergillus niger 26
Spectrochim. Acta A. Mol. Biomol. Spectrosc.
71
975-983
2008
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3
1
1
2
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1
1
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-
-
-
-
700696
Hünken
Epiphytic bacteria on the Anta ...
Amphiprora kufferathii, no activity in Colwellia sp., no activity in Colwellia sp. MH3, Pibocella sp., Pibocella sp. MH3, Sulfitobacter sp., Sulfitobacter sp. MH1
Plant Biol.
10
519-526
2008
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4
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13
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701484
Trinh
Purification, crystallization ...
Caenorhabditis elegans
Acta Crystallogr. Sect. F
64
1110-1114
2008
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705498
Mateo
Purification and biochemical c ...
Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
103
271-276
2008
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2
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1
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1
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4
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1
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1
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4
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-
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-
705834
Guo
Purification and characterizat ...
Chaetomium thermophilum, Chaetomium thermophilum CT2
Mycologia
100
375-380
2008
-
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-
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2
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2
2
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6
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1
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1
1
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2
1
1
4
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1
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2
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1
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2
1
1
4
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1
1
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706067
Kang
Identification and characteriz ...
Cryptosporidium parvum
Parasitol. Res.
103
787-795
2008
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1
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2
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2
1
2
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3
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2
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1
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1
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1
-
1
1
1
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-
1
1
-
-
-
706372
Kochhar
Identification and characteriz ...
Curcuma longa
Planta
228
307-318
2008
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2
4
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2
2
2
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2
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1
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1
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1
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4
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1
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706617
Merlino
Crystallization and preliminar ...
Pseudoalteromonas haloplanktis
Protein Pept. Lett.
15
415-418
2008
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1
1
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3
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671561
He
Characterization of a hyperthe ...
uncultured bacterium
Appl. Microbiol. Biotechnol.
75
367-376
2007
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5
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1
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1
3
-
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2
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1
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-
-
-
-
671901
Agbas
Activation of brain calcineuri ...
Bos taurus, Homo sapiens
Biochem. J.
405
51-59
2007
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8
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2
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-
-
-
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-
-
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-
673149
Akita
Purification, identification, ...
Mesocricetus auratus
Comp. Biochem. Physiol. A
46
223-232
2007
-
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1
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1
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2
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3
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2
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1
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1
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1
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-
-
673992
Keith
Characterization of SodC, a pe ...
Burkholderia cenocepacia, Burkholderia cenocepacia K56-2
Infect. Immun.
75
2451-2460
2007
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1
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1
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1
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1
4
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2
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10
-
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4
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4
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4
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-
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675150
Gucciardo
A germin-like protein with sup ...
Pisum sativum
J. Exp. Bot.
58
1161-1171
2007
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1
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2
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5
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1
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1
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4
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-
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-
-
675243
Jiang
Roles of exogenous divalent me ...
Bos taurus
J. Inorg. Biochem.
101
667-677
2007
-
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3
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1
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1
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-
-
-
-
-
677687
Iiyama
Effect of superoxide dismutase ...
Pseudomonas aeruginosa
Appl. Environ. Microbiol.
73
1569-1575
2007
-
-
1
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1
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2
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1
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5
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1
1
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1
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1
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1
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2
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1
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1
1
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1
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-
-
-
684416
Deitrich
Chemical preparation of an iso ...
Bos taurus
Anal. Chem.
79
8381-8390
2007
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1
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3
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2
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3
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1
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1
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2
1
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3
1
-
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1
-
1
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-
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-
-
-
-
684538
Yamamoto
-
Characterization of superoxide ...
Bombyx mori, Hyphantria cunea
Appl. Entomol. Zool.
42
465-472
2007
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-
2
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6
2
2
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2
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1
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4
2
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5
2
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2
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2
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2
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2
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6
2
2
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1
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4
2
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5
2
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2
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2
2
-
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-
685124
Zheng
Structural and kinetic study o ...
Homo sapiens
Biochemistry
46
14830-14837
2007
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-
1
1
2
-
1
1
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1
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1
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3
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2
1
1
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1
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2
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2
1
1
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1
1
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685651
Shijin
Purification, characterization ...
Thermoascus aurantiacus
Biosci. Biotechnol. Biochem.
71
1090-1093
2007
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1
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2
2
1
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3
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1
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5
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1
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1
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1
1
-
1
1
-
-
5
-
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685864
Verreth
Rosuvastatin restores superoxi ...
Mus musculus
Br. J. Pharmacol.
151
347-355
2007
1
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1
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1
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4
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3
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685881
Trubiani
Teneurin carboxy (C)-terminal ...
Mus musculus
Brain Res.
1176
27-36
2007
1
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1
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2
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1
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2
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5
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1
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686615
Hodyc
Superoxide dismutase mimetic t ...
Rattus norvegicus
Exp. Physiol.
92
945-951
2007
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1
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2
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686786
Wang
Two distinct manganese-contain ...
Bacillus cereus, Bacillus cereus 905
FEMS Microbiol. Lett.
272
206-213
2007
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1
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1
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1
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4
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9
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8
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2
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8
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687064
Prabhu
Inhibition of selenium depende ...
Rattus norvegicus
Indian J. Exp. Biol.
45
465-468
2007
1
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2
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1
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2
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2
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687161
Smyth
Comprehensive characterization ...
Rattus norvegicus
Int. J. Exp. Pathol.
88
361-376
2007
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1
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1
2
1
1
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2
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4
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2
1
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1
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1
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4
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2
1
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-
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687311
Braesen
Extracellular superoxide dismu ...
Oryctolagus cuniculus
J. Am. Coll. Cardiol.
50
2249-2253
2007
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1
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1
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1
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3
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3
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2
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-
-
-
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688077
Rodriguez-Serrano
Peroxisomal membrane manganese ...
Citrullus lanatus
J. Exp. Bot.
58
2417-2427
2007
-
-
-
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3
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3
1
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3
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1
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1
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1
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3
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1
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1
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2
1
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2
1
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2
-
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-
-
-
688384
Roberts
Structural characterization of ...
Homo sapiens
J. Mol. Biol.
373
877-890
2007
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1
1
8
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2
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1
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2
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1
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1
1
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1
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1
8
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1
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1
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1
1
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-
-
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688722
Kawakami
Testicular superoxide dismutas ...
Canis lupus familiaris
J. Vet. Med. Sci.
69
1259-1262
2007
-
-
-
-
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1
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5
1
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1
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1
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5
1
-
1
-
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-
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-
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-
688805
Thirach
The copper, zinc superoxide di ...
Talaromyces marneffei
Med. Mycol.
45
409-417
2007
-
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1
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2
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1
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5
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5
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1
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5
-
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2
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-
-
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-
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-
-
688841
Lima
Molecular cloning and biochemi ...
Scedosporium apiospermum
Microbes Infect.
9
558-565
2007
1
-
1
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3
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2
1
1
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5
-
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1
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3
1
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1
1
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2
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1
1
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1
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1
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3
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1
1
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1
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3
1
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1
1
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2
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1
1
-
-
-
-
-
-
-
-
688844
Chen
Demonstration and characteriza ...
Providencia alcalifaciens
Microbiol. Immunol.
51
951-961
2007
-
-
1
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1
-
-
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1
1
1
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6
-
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1
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-
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2
1
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1
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1
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1
1
1
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1
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2
1
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-
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-
-
-
-
-
-
-
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688985
Seo
Characterization of an iron- a ...
Methylobacillus sp., Methylobacillus sp. SK1 / DSM 8269
Mol. Cells
23
370-378
2007
-
-
-
-
-
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2
-
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2
2
2
-
11
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1
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1
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2
1
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6
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1
1
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1
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2
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2
2
2
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1
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1
-
2
1
-
-
6
-
1
1
-
1
-
-
-
-
-
-
671108
Dennis
Structure of the manganese sup ...
Deinococcus radiodurans
Acta Crystallogr. Sect. F
62
325-329
2006
-
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1
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-
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3
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1
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672084
Ye
Binding of polyaminocarboxylat ...
Bos taurus
Biochemistry
45
12723-12732
2006
-
-
-
-
-
-
2
-
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1
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1
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1
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-
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-
-
-
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-
-
-
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-
-
-
-
672303
Brioukhanov
Purification and characterizat ...
Methanobrevibacter arboriphilus, Methanobrevibacter arboriphilus AZ
Biochemistry (Moscow)
71
441-447
2006
-
-
-
-
-
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3
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2
3
-
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5
-
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1
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1
2
2
1
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3
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2
3
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1
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1
2
2
1
-
-
-
-
-
-
-
-
-
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-
-
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672386
De Domenico
Purification and characterizat ...
Caulobacter vibrioides
Biochim. Biophys. Acta
1764
105-109
2006
-
-
-
-
-
-
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2
2
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4
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1
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1
1
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2
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2
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1
-
1
1
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2
-
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-
-
-
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-
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672442
Castellano
Psychrophilic superoxide dismu ...
Pseudoalteromonas haloplanktis
Biochimie
88
1377-1389
2006
-
-
-
-
-
-
3
-
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2
4
-
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6
-
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1
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1
1
1
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1
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3
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2
4
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1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
672642
Whittaker
Kinetic analysis of the metal ...
Escherichia coli
Biophys. J.
90
598-607
2006
-
-
-
-
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1
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3
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1
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672748
Zheng
Purification and characterizat ...
Marinomonas sp., Marinomonas sp. NJ522
Biotechnol. Lett.
28
85-88
2006
4
-
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4
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2
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4
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1
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2
1
2
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1
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1
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4
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4
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2
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1
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2
1
2
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1
-
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1
-
-
-
-
-
-
-
-
673161
Ekanayake
-
Molecular cloning and characte ...
Haliotis discus
Comp. Biochem. Physiol. B
145B
318-324
2006
-
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1
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1
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1
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1
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1
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1
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1
1
2
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2
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1
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1
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1
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1
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1
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1
-
1
1
2
-
-
-
2
-
-
1
-
-
-
-
-
-
673321
Yang
The effects of mitochondrial i ...
Saccharomyces cerevisiae
EMBO J.
25
1775-1783
2006
-
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-
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1
2
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3
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1
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673565
Chockalingam
Engineering and characterizati ...
Homo sapiens
FEBS J.
273
4853-4861
2006
-
-
-
-
6
-
1
1
1
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2
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-
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1
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1
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6
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1
1
1
1
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1
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-
-
-
-
-
-
-
-
-
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-
-
-
-
673792
Dufernez
The presence of four iron-cont ...
Trypanosoma brucei
Free Radic. Biol. Med.
40
210-225
2006
-
-
-
-
-
-
-
-
3
-
4
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7
-
1
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-
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1
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-
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2
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4
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4
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2
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4
-
-
-
-
-
-
-
2
-
-
-
-
-
-
673794
Quint
Crystal structure of nitrated ...
Homo sapiens
Free Radic. Biol. Med.
40
453-458
2006
-
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1
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1
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2
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1
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1
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-
-
-
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-
-
-
-
673801
Goldstein
Kinetic properties of Cu,Zn-su ...
Bos taurus
Free Radic. Biol. Med.
41
937-941
2006
-
-
-
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1
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1
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673919
Kinnula
Extracellular superoxide dismu ...
Homo sapiens
Histopathology
49
66-74
2006
-
1
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3
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674025
Ikebuchi
Primary structure and properti ...
Mizuhopecten yessoensis
Int. J. Biochem. Cell Biol.
38
521-532
2006
-
-
-
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3
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1
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1
1
2
1
1
-
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1
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1
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2
-
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-
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-
-
674126
Chen
Production and characterizatio ...
Homo sapiens
J. Agric. Food Chem.
54
8041-8047
2006
-
1
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1
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4
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1
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-
674931
Jiang
Divalent-metal-dependent nucle ...
Bos taurus
J. Biol. Inorg. Chem.
11
835-848
2006
-
-
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2
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1
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1
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-
675503
Ren
-
Kinetic and structural charact ...
Homo sapiens
J. Mol. Struct.
790
168-173
2006
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1
2
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1
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1
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4
-
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-
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-
676294
Wu
Cloning and characterization o ...
Trichinella pseudospiralis
Parasitol. Res.
98
281-287
2006
-
-
-
-
-
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2
-
1
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7
-
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1
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1
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-
676478
Tang
Enhanced tolerance of transgen ...
Manihot esculenta
Plant Cell Rep.
25
1380-1386
2006
-
1
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2
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-
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-
-
-
-
658669
Li
A thermostable manganese-conta ...
Thermomyces lanuginosus, Thermomyces lanuginosus P134
Extremophiles
9
1-6
2005
-
-
-
-
-
-
2
-
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2
-
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3
-
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1
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1
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2
1
1
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5
-
1
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2
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2
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1
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1
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2
1
1
-
5
-
1
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-
-
-
-
-
-
-
658957
Ken
Characterization of Fe/Mn-supe ...
Conticribra weissflogii
J. Agric. Food Chem.
53
1470-1474
2005
-
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1
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2
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2
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5
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1
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1
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1
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1
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1
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1
-
-
-
-
-
-
-
659568
Haddad
Purification and some properti ...
Radix lethospermi
J. Chromatogr. B
818
123-131
2005
-
-
-
-
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5
-
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2
2
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2
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1
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2
1
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1
1
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1
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1
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5
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2
2
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1
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2
1
-
1
1
-
-
1
-
-
-
1
-
-
-
-
-
-
-
660467
Munoz
The crystal structure of an eu ...
Vigna unguiculata
Protein Sci.
14
387-394
2005
-
-
-
1
-
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1
1
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4
-
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-
-
-
-
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-
-
-
-
671586
Michel
Kinetics properties of Cu,Zn-s ...
Bos taurus
Arch. Biochem. Biophys.
439
234-240
2005
-
-
-
-
-
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1
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2
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2
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1
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-
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-
-
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-
-
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-
-
-
-
672026
Miller
Anion binding properties of re ...
Escherichia coli
Biochemistry
44
5969-5981
2005
-
-
-
-
1
-
2
1
-
1
-
-
-
2
-
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1
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672292
Klebanov
Changes in superoxide dismutas ...
Rattus norvegicus
Biochemistry (Moscow)
70
1335-1340
2005
-
-
-
-
-
-
-
-
-
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2
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2
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673154
Yamamoto
-
Molecular and biochemical char ...
Bombyx mori
Comp. Biochem. Physiol. B
142B
403-409
2005
-
-
-
-
-
-
-
-
-
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2
-
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1
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1
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1
1
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1
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1
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1
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2
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1
-
1
1
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-
1
-
-
-
1
1
-
-
-
-
-
-
673379
Wang
-
Purification and partial chara ...
Cordyceps militaris
Enzyme Microb. Technol.
36
862-869
2005
-
-
-
-
-
-
2
-
1
2
2
-
-
1
-
-
1
-
-
1
1
-
1
1
-
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2
-
1
-
1
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-
1
-
-
-
-
-
-
-
-
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2
-
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1
2
2
-
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1
-
1
1
-
1
1
-
-
2
-
1
-
1
1
-
-
-
-
-
-
673405
Giles
Cryptococcus neoformans mitoch ...
Cryptococcus neoformans
Eukaryot. Cell
4
46-54
2005
-
1
-
-
1
-
-
-
2
-
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1
-
5
-
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1
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1
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1
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1
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1
-
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-
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-
-
-
-
-
-
-
-
674105
Huang
Biochemical characterization o ...
Conticribra weissflogii
J. Agric. Food Chem.
53
6319-6325
2005
-
-
1
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1
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2
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5
-
-
-
-
-
-
-
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1
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1
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1
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1
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2
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-
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-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
674166
Tabares
Temperature-dependent coordina ...
Escherichia coli
J. Am. Chem. Soc.
127
6039-6047
2005
-
-
-
-
-
-
-
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-
1
-
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4
-
-
-
-
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1
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-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
674446
Luk
Manganese activation of supero ...
Saccharomyces cerevisiae
J. Biol. Chem.
280
22715-22720
2005
-
-
-
-
-
-
-
-
2
1
-
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4
-
-
-
-
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2
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675047
Wang
Purification and partial chara ...
Cordyceps militaris
J. Chromatogr. B
826
114-121
2005
-
-
-
-
-
-
2
-
-
2
2
-
-
4
-
-
1
-
-
-
2
-
1
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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2
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2
2
-
-
-
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1
-
-
2
-
1
1
-
-
1
-
-
-
-
1
-
-
-
-
-
-
675093
Raza
Manganese superoxide dismutase ...
Rattus norvegicus
J. Endocrinol.
184
77-84
2005
1
-
-
-
-
-
-
-
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1
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3
-
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-
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2
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1
1
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-
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1
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1
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2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675625
Guzik
Superoxide dismutase activity ...
Homo sapiens
J. Physiol. Pharmacol.
56
313-323
2005
-
1
-
-
-
-
-
-
-
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2
-
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4
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1
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4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675647
Miszalski
Cu/Zn superoxide dismutase and ...
Pinus mugo
J. Plant Physiol.
162
895-902
2005
-
-
-
-
-
-
-
-
-
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1
-
2
-
-
-
-
-
2
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1
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-
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1
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2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676119
Blackman
Characterisation of manganese ...
Phytophthora nicotianae
Mycol. Res.
109
1171-1183
2005
-
-
-
-
-
-
-
-
-
-
-
-
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5
-
-
-
-
-
6
-
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1
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-
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6
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676295
Li
Molecular cloning and characte ...
Clonorchis sinensis
Parasitology
130
687-697
2005
-
1
-
-
-
-
3
-
1
-
4
-
-
8
-
-
-
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-
-
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-
1
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2
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3
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1
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4
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676585
Chu
A copper chaperone for superox ...
Arabidopsis thaliana
Plant Physiol.
139
425-436
2005
-
-
-
-
-
-
-
-
3
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4
-
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3
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676794
Banci
A prokaryotic superoxide dismu ...
Bacillus subtilis
Proc. Natl. Acad. Sci. USA
102
7541-7546
2005
-
-
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1
-
-
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1
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4
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676948
Ken
Unusual stability of manganese ...
Tatumella ptyseos
Protein Expr. Purif.
40
42-50
2005
-
-
1
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-
-
-
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1
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-
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3
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1
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1
2
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2
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1
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1
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1
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1
2
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-
-
-
2
-
-
-
-
-
-
-
657631
Yao
-
Purification and partial chara ...
Macrobrachium nipponense
Aquaculture
241
621-631
2004
3
-
-
-
-
-
4
-
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1
1
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1
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1
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1
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1
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1
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3
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4
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1
1
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1
-
1
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
658041
Petersen
The structure of rabbit extrac ...
Oryctolagus cuniculus
Biochemistry
43
14275-14281
2004
-
-
-
-
-
-
-
-
1
-
-
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-
6
-
1
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1
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1
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-
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-
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-
-
-
658667
Yun
Purification and some properti ...
Deinococcus radiophilus
Extremophiles
8
237-242
2004
-
-
-
-
-
-
5
-
1
2
3
-
-
5
-
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1
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1
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1
2
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1
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5
-
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1
2
3
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1
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1
-
1
2
-
-
1
-
-
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1
1
-
-
-
-
-
-
658772
Kho
Characterization of Cu- and Zn ...
Rhodobacter sphaeroides
FEMS Microbiol. Lett.
234
261-267
2004
-
-
-
-
1
-
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3
-
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1
-
2
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1
-
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659042
Lancaster
A cambialistic superoxide dism ...
Chloroflexus aurantiacus
J. Bacteriol.
186
3408-3414
2004
-
-
1
-
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1
-
1
2
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5
-
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5
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5
-
1
-
-
-
-
-
-
-
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-
-
-
-
-
659402
Regelsberger
The iron superoxide dismutase ...
Nostoc sp.
J. Biol. Chem.
279
44384-44393
2004
-
-
-
-
-
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4
-
1
1
2
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4
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1
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1
1
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1
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1
1
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-
2
-
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-
-
-
-
659618
Kumar
-
Partial purification and chara ...
Solanum lycopersicum
J. Food Sci. Nutr.
9
283-288
2004
-
-
-
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4
2
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3
2
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1
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1
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1
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4
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2
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2
1
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1
-
1
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-
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-
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659780
Cho
Cloning, expression, and chara ...
Neospora caninum
J. Parasitol.
90
278-285
2004
-
-
1
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2
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1
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660056
Marin
Purification and characterizat ...
Phytomonas sp.
Parasitology
129
79-86
2004
-
1
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2
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2
-
2
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5
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1
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1
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2
-
-
-
-
-
-
660069
Sivaprakasam
-
Purification and characterizat ...
Psidium guajava
Physiol. Mol. Biol. Plants
10
59-64
2004
-
-
-
-
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5
2
-
2
2
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1
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1
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1
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1
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5
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2
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1
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1
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2
1
-
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1
-
1
-
-
-
-
-
-
-
-
-
660283
Sheng
-
Purification and characterizat ...
Nicotiana tabacum
Plant Sci.
167
1235-1241
2004
-
-
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5
-
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2
1
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1
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1
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5
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1
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1
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1
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1
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-
1
-
-
-
1
-
-
-
-
-
-
-
660436
Ahl
Coexpression of yeast copper c ...
Homo sapiens
Protein Expr. Purif.
37
311-319
2004
-
1
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3
-
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1
2
1
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5
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1
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-
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-
-
-
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660490
Tolfo Bittencourt
Purification and ultrastructur ...
Metarhizium anisopliae
Res. Microbiol.
155
681-687
2004
-
-
-
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1
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2
1
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2
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1
1
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1
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1
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1
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1
1
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
678129
Gogliettino
The role of Tyr41 and His155 i ...
Saccharolobus solfataricus
Biochemistry
43
2199-2208
2004
-
-
1
1
2
1
2
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1
2
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3
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3
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1
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1
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1
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2
1
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2
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1
2
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3
-
1
1
-
-
1
-
1
-
-
1
-
-
-
-
-
-
657444
Munoz
Crystallization and preliminar ...
Vigna unguiculata
Acta Crystallogr. Sect. D
59
1070-1072
2003
-
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-
1
-
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1
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-
657532
Ahmed
Superoxide dismutases from the ...
Perkinsus marinus
Anal. Biochem.
318
132-141
2003
-
-
-
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2
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2
1
1
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4
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1
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1
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1
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2
-
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-
-
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-
-
-
-
657632
Manduzio
Characterization of an inducib ...
Mytilus edulis
Aquat. Toxicol.
64
73-83
2003
-
-
-
-
-
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2
3
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2
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2
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2
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-
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3
-
-
-
-
-
-
657896
Whittaker
The irony of manganese superox ...
Thermus thermophilus
Biochem. Soc. Trans.
31
1318-1321
2003
-
-
-
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1
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-
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-
-
-
-
658951
Ken
Copper/zinc-superoxide dismuta ...
Epinephelus malabaricus
J. Agric. Food Chem.
51
5688-5694
2003
-
-
1
-
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-
1
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3
-
1
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1
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1
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-
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-
-
1
-
-
-
2
-
-
-
-
-
-
-
659525
Kerfeld
The 1.6 ANG resolution structu ...
Thermosynechococcus elongatus
J. Biol. Inorg. Chem.
8
707-714
2003
-
-
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1
-
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1
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3
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1
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-
-
-
-
-
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-
-
-
-
-
-
-
-
659841
Ken
Characterization of fish Cu/Zn ...
Danio rerio
Mar. Biotechnol.
5
167-173
2003
-
1
1
-
-
-
1
-
-
-
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5
-
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1
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1
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1
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1
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1
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1
-
1
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-
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1
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-
-
1
-
-
-
-
-
-
-
660230
Moran
Functional characterization an ...
Vigna unguiculata
Plant Physiol.
133
773-782
2003
-
-
-
-
-
-
-
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2
1
3
-
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6
-
1
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3
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1
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1
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2
1
3
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1
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3
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1
-
-
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-
1
-
-
-
-
-
-
675341
DiDonato
ALS Mutants o human superoxide ...
Homo sapiens
J. Mol. Biol.
332
601-615
2003
-
1
-
1
2
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2
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3
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
679527
Heim
Proteome reference map of Pseu ...
Pseudomonas putida
Environ. Microbiol.
5
1257-1269
2003
-
-
1
-
-
-
-
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2
1
-
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7
-
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1
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1
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2
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1
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2
1
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1
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-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
727741
Amo
Biochemical properties and reg ...
Pyrobaculum calidifontis, Pyrobaculum calidifontis JCM 11548
J. Bacteriol.
185
6340-6347
2003
-
-
1
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1
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1
2
2
-
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6
-
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1
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1
3
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1
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1
-
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1
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1
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1
2
2
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1
-
1
3
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
438179
Liu
cDNA cloning, high-level expre ...
Anas platyrhynchos domestica, Anas platyrhynchos domestica CuZn-SOD
Protein Expr. Purif.
25
379-388
2002
-
-
1
-
-
-
-
-
-
2
2
-
-
5
-
-
1
1
-
-
-
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2
1
-
-
1
-
-
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1
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2
2
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1
-
-
-
-
2
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
438180
He
High-level expression of human ...
Homo sapiens
Protein Expr. Purif.
24
13-17
2002
-
-
1
-
-
-
-
-
1
2
1
-
-
3
-
1
1
-
1
-
1
-
1
1
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-
-
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-
1
-
-
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1
2
1
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1
1
1
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438183
Chen
Structural studies of an eukar ...
Cinnamomum camphora, Cinnamomum camphora Fe-SOD
Arch. Biochem. Biophys.
404
218-226
2002
-
-
1
-
-
-
-
-
-
1
1
-
-
4
-
-
1
-
1
2
1
-
1
1
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-
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1
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-
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1
1
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1
1
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438189
Lin
Copper/zinc-superoxide dismuta ...
Citrus limon, Citrus limon CuZn-SOD
J. Agric. Food Chem.
50
7264-7270
2002
-
-
1
-
-
1
-
-
-
2
-
-
-
5
-
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1
1
-
1
1
-
1
3
-
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1
-
-
-
1
-
-
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1
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-
1
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2
-
-
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1
-
1
1
-
1
3
-
-
1
-
-
-
1
-
-
-
-
-
-
-
438171
Lamarre
Candida albicans expresses an ...
Candida albicans
J. Biol. Chem.
276
43784-43791
2001
-
-
1
-
-
-
2
-
3
3
2
1
-
4
-
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1
1
1
-
1
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2
1
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-
-
-
-
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1
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2
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3
3
2
1
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1
1
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438176
Ozturk-Urek
Purification and characterizat ...
Gallus gallus, Gallus gallus CuZn-SOD
Comp. Biochem. Physiol. B
128
205-212
2001
-
-
-
-
-
-
4
-
-
2
2
-
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3
-
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1
-
-
2
1
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2
1
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2
-
1
-
1
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-
-
-
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4
-
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2
2
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1
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2
1
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-
2
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1
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1
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-
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679627
De Vendittis
Phenylmethanesulfonyl fluoride ...
Saccharolobus solfataricus
Eur. J. Biochem.
268
1794-1801
2001
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1
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1
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1
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1
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725344
Abreu
The mechanism of superoxide sc ...
Archaeoglobus fulgidus
J. Biol. Chem.
276
38995-39001
2001
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1
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2
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2
1
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1
1
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-
438172
Holdom
Production and characterizatio ...
Aspergillus fumigatus, Aspergillus fumigatus Af293
J. Clin. Microbiol.
38
558-562
2000
-
1
1
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3
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2
2
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6
-
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1
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2
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2
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1
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1
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2
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1
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1
1
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-
438185
Cannio
A superoxide dismutase from th ...
Saccharolobus solfataricus, Saccharolobus solfataricus Gtheta
Eur. J. Biochem.
267
235-243
2000
-
-
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2
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2
4
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5
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1
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1
2
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6
2
1
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1
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4
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1
2
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6
2
1
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1
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-
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-
-
-
-
438187
Dos Santos
Purification and characterizat ...
Desulfovibrio gigas, Desulfovibrio gigas Fe-SOD
J. Bacteriol.
182
796-804
2000
-
-
-
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3
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1
2
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5
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1
1
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1
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1
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1
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2
1
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1
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1
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438191
Carter
Tobacco nectarin I. Purificati ...
Nicotiana sp.
J. Biol. Chem.
275
36726-36733
2000
-
-
-
-
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2
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1
1
1
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4
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1
1
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1
2
1
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1
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2
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1
1
1
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1
1
2
1
-
1
2
-
-
2
-
-
-
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-
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-
-
-
-
677652
Kim
Superoxide dismutase activity ...
Pseudomonas putida
Appl. Environ. Microbiol.
66
1460-1467
2000
-
-
-
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1
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2
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2
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2
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1
1
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2
-
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-
-
725560
Whittaker
Recombinant superoxide dismuta ...
Pyrobaculum aerophilum, Pyrobaculum aerophilum IM2
J. Biol. Inorg. Chem.
5
402-408
2000
-
-
1
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2
3
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10
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1
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1
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1
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3
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1
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-
1
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-
-
-
-
-
-
-
-
-
-
-
-
726829
Brioukhanov
Protection of Methanosarcina b ...
Methanosarcina barkeri
Arch. Microbiol.
174
213-216
2000
-
-
1
-
-
-
1
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1
1
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7
-
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1
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1
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1
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1
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-
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-
-
-
-
438173
Barnes
-
Superoxide dismutase and catal ...
Photobacterium damselae subsp. piscicida, Photobacterium damselae subsp. piscicida Fe-SOD
Microbiology
145
483-494
1999
-
-
-
-
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3
-
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1
2
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1
2
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1
1
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1
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1
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1
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2
1
1
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-
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1
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-
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-
-
-
-
-
438188
Santos
Characterization of an atypica ...
Sinorhizobium meliloti, Sinorhizobium meliloti Rm5000
J. Bacteriol.
181
4509-4516
1999
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-
1
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1
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2
2
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8
-
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1
1
1
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1
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2
1
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1
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2
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1
1
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1
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2
1
-
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-
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-
-
-
-
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-
-
-
-
680532
Yamano
An azide-insensitive superoxid ...
Saccharolobus solfataricus
J. Biochem.
125
186-193
1999
-
-
1
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1
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3
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4
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1
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1
1
4
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1
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1
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3
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1
1
1
4
-
-
-
1
-
3
-
1
-
-
-
-
-
-
-
-
-
681369
Knapp
Refined crystal structure of a ...
Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DSM 639
J. Mol. Biol.
285
689-702
1999
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-
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1
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1
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22
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1
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2
1
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1
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1
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1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681370
Ursby
Iron superoxide dismutase from ...
Saccharolobus solfataricus
J. Mol. Biol.
286
189-205
1999
-
-
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1
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1
2
1
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3
1
1
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1
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1
2
1
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-
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3
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
727790
Yamano
A cambialistic SOD in a strict ...
Aeropyrum pernix, Aeropyrum pernix DSM 11879
J. Biochem.
126
218-225
1999
-
-
1
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3
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2
2
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5
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1
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1
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2
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1
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3
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2
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1
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-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
742401
Oeztuerk
-
Purification and characteriza ...
Phanerochaete chrysosporium
Enzyme Microb. Technol.
25
392-399
1999
-
1
-
-
-
-
6
-
-
-
1
-
-
1
-
-
1
-
-
-
-
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-
1
-
-
1
-
1
-
1
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1
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-
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6
-
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-
1
-
-
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1
-
-
-
-
-
1
-
-
1
-
1
-
1
-
-
-
-
-
-
-
438175
Kim
Expression, purification, and ...
Homo sapiens, Homo sapiens CuZn-SOD
Mol. Cells
8
478-482
1998
-
-
1
-
1
-
2
-
-
2
-
-
-
13
-
-
1
-
-
-
-
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2
1
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-
-
-
-
-
-
-
-
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-
1
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-
1
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2
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2
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1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438184
Palma
-
Peroxisomal manganese superoxi ...
Pisum sativum, Pisum sativum Mn-SOD
Physiol. Plant.
104
720-726
1998
-
-
-
-
-
-
-
-
1
-
2
-
-
4
-
-
1
1
-
1
1
-
2
1
-
-
-
-
-
-
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-
-
-
-
-
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-
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1
-
2
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1
-
1
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438190
Borders
Characterization of recombinan ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae Mn-SOD
Biochemistry
37
11323-11331
1998
-
-
1
-
2
-
2
-
-
1
-
-
-
6
-
-
-
1
-
-
1
-
2
-
1
-
1
-
1
-
-
-
-
-
-
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1
-
-
2
-
-
2
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-
1
-
-
-
-
-
-
-
-
1
-
2
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
438177
An
Purification and characterizat ...
Pseudomonas carboxydohydrogena, Pseudomonas carboxydohydrogena Mn-SOD
Mol. Cells
7
730-737
1997
-
-
-
-
-
-
3
-
-
1
2
-
-
7
-
-
1
1
-
-
1
-
2
1
1
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
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1
2
-
-
-
-
1
-
-
1
-
2
1
1
-
3
-
1
-
-
-
-
-
-
-
-
-
438178
Kang
-
Expression and characterizatio ...
Homo sapiens, Homo sapiens CuZn-SOD
J. Biochem. Mol. Biol.
30
60-65
1997
-
-
1
-
-
-
1
-
-
-
-
-
-
11
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
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1
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1
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1
-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678369
Dello Russo
Iron superoxide dismutase from ...
Saccharolobus solfataricus, Saccharolobus solfataricus MT-4 / DSM 5833
Biochim. Biophys. Acta
1343
23-30
1997
-
-
1
-
-
-
3
-
-
1
1
-
-
22
-
-
1
-
-
-
-
-
-
1
1
-
1
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
3
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
1
-
-
1
-
-
-
-
-
-
438170
Tanaka
Purification of the cytosolic ...
Marchantia paleacea, Marchantia paleacea CuZn-SOD
Plant Cell Physiol.
37
523-529
1996
-
-
-
-
-
-
-
-
3
2
2
-
-
5
-
-
1
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
2
2
-
-
-
-
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438182
Holdom
The Cu,Zn superoxide dismutase ...
Aspergillus flavus, Aspergillus flavus CuZn-SOD, Aspergillus nidulans, Aspergillus nidulans CuZn-SOD, Aspergillus niger, Aspergillus niger CuZn-SOD, Aspergillus terreus, Aspergillus terreus CuZn-SOD
Infect. Immun.
64
3326-3332
1996
-
-
-
-
-
-
20
-
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8
8
-
-
14
-
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4
4
-
-
4
-
8
4
-
-
8
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
20
-
-
-
8
8
-
-
-
-
4
-
-
4
-
8
4
-
-
8
-
4
-
-
-
-
-
-
-
-
-
678510
Schaefer
Three extremely thermostable p ...
Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DSM 639
Biol. Chem.
377
505-512
1996
-
-
-
-
-
2
1
-
3
-
1
-
1
9
-
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1
-
-
1
-
-
-
1
1
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
4
-
2
-
1
-
-
1
-
1
-
-
-
2
1
-
2
-
1
-
-
-
-
-
-
-
-
-
719516
Kardinahl
Isolation, characterization an ...
Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DSM 639
FEMS Microbiol. Lett.
138
65-70
1996
-
-
-
1
-
2
-
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2
1
3
-
2
6
-
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1
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
2
1
3
-
2
-
-
1
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438174
Fujii
Characterization of wild-type ...
Homo sapiens, Homo sapiens CuZn-SOD
J. Neurochem.
64
1456-1461
1995
-
1
1
-
3
-
-
-
-
2
-
-
-
13
-
-
1
-
1
1
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
3
-
-
-
-
-
-
2
-
-
-
-
-
1
1
1
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
438181
Ikeda
Purification and characterizat ...
Canis lupus familiaris, Canis lupus familiaris CuZn-SOD
Int. J. Biochem. Cell Biol.
27
1257-1265
1995
-
-
-
-
-
-
-
-
-
1
3
-
-
3
-
-
1
-
-
4
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
-
1
-
4
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438186
Banci
Mutation of the metal-bridging ...
Homo sapiens, Homo sapiens CuZn-SOD
Eur. J. Biochem.
232
220-225
1995
-
-
1
-
1
-
-
-
-
2
-
-
-
14
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678366
Klenk
Nucleotide sequence, transcrip ...
Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DSM 639
Biochim. Biophys. Acta
1174
95-98
1993
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-
1
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2
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6
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-
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438111
Bueno
Purification and properties of ...
Citrullus lanatus subsp. vulgaris
Plant Physiol.
98
331-336
1992
-
-
-
-
-
-
-
-
2
4
2
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3
-
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1
-
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2
1
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1
1
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2
4
2
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1
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438169
Ramanaiah
Characterization of superoxide ...
Heterometrus fulvipes, Heterometrus fulvipes Mn-SOD
Biochem. Int.
26
113-123
1992
-
-
-
-
-
-
13
-
1
1
1
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3
-
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1
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2
1
-
2
1
1
-
2
-
1
1
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13
-
-
1
1
1
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1
-
2
1
-
2
1
1
-
2
-
1
1
-
-
-
-
-
-
-
-
438096
Beyer
SODs: varieties and distributi ...
Bacteroides fragilis, Bacteroides thetaiotaomicron, Caulobacter vibrioides, Caulobacter vibrioides CuZn-SOD, Escherichia coli, Escherichia coli Fe-SOD, Escherichia coli Mn-SOD, Geobacillus stearothermophilus, Geobacillus stearothermophilus Mn-SOD, Ginkgo biloba, Gordonia bronchialis, Halobacterium salinarum, Homo sapiens, Leptolyngbya boryana, Methanobacterium bryantii, Mus musculus, Mycolicibacterium phlei, Nocardia asteroides, Paracoccus denitrificans, Paracoccus denitrificans CuZn-SOD, Photobacterium leiognathi, Photobacterium leiognathi CuZn-SOD, Propionibacterium freudenreichii subsp. shermanii, Pseudomonas putida, Pseudomonas putida Fe-SOD, Rattus norvegicus, Saccharomyces cerevisiae, Streptococcus mutans, Synechococcus elongatus PCC 7942, Thermoplasma acidophilum, Thermoplasma acidophilum Fe-SOD, Thermus thermophilus, Thermus thermophilus Mn-SOD, Zea mays
Prog. Nucleic Acid Res. Mol. Biol.
40
221-253
1991
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-
-
-
2
-
39
-
36
80
14
24
-
46
-
11
-
20
1
-
20
-
58
31
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
2
-
-
39
-
-
36
80
14
24
-
-
11
-
1
-
20
-
58
31
-
-
-
-
-
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-
-
-
-
-
-
-
-
438101
Kim
Purification and characterizat ...
Klebsiella aerogenes, Klebsiella aerogenes IFO 3317
Agric. Biol. Chem.
55
101-108
1991
-
-
-
-
-
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4
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1
2
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3
-
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1
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1
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2
1
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1
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2
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4
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1
2
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1
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1
-
2
1
-
-
1
-
-
-
2
-
-
-
-
-
-
-
438104
Walker
-
Isolation and purification of ...
Brassica oleracea, Brassica oleracea CuZn-SOD
Food Chem.
41
1-9
1991
-
-
-
-
-
-
1
-
-
2
2
-
-
2
-
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1
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1
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2
1
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1
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1
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2
2
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1
-
1
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-
2
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
438107
Takao
Unique characteristics of supe ...
Methanothermobacter thermautotrophicus
J. Biol. Chem.
266
14151-14154
1991
-
-
1
-
-
-
3
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1
2
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5
-
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1
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1
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1
1
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1
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3
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1
2
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1
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1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438108
Wingsle
Isolation, purification, and s ...
Pinus sylvestris
Plant Physiol.
95
21-28
1991
-
-
-
-
-
-
2
-
2
2
3
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-
2
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1
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1
1
1
1
1
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-
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2
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2
2
3
-
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-
1
-
1
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438109
Callahan
Dirofilaria immitis superoxide ...
Dirofilaria immitis, Dirofilaria immitis CuZn-SOD
Mol. Biochem. Parasitol.
49
245-252
1991
-
-
-
-
-
-
-
-
1
-
2
2
-
5
-
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1
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1
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4
1
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1
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2
2
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1
-
-
1
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438092
Amano
The primary structure of super ...
Porphyromonas gingivalis
FEBS Lett.
272
217-220
1990
-
-
-
-
-
-
-
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2
1
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3
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1
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2
1
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1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
438094
Redford
Crystallographic characterizat ...
Photobacterium leiognathi, Photobacterium leiognathi ATCC 25521, Photobacterium leiognathi CuZn-SOD
J. Mol. Biol.
212
449-451
1990
-
-
-
1
-
-
-
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1
-
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8
-
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1
-
-
-
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3
1
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-
-
-
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-
1
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1
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1
-
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-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438102
Sulochana
Purification of isozymes of su ...
Arachis hypogaea
Biochem. Int.
22
133-140
1990
-
-
-
-
-
-
-
-
3
3
-
-
-
1
-
-
1
-
-
1
1
-
1
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
3
3
-
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
438103
Denariaz
-
Characterization of the supero ...
Virgibacillus halodenitrificans, Virgibacillus halodenitrificans Mn-SOD
Biol. Met.
3
14-18
1990
-
-
-
-
-
-
2
-
-
1
2
-
-
2
-
-
1
-
-
-
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1
2
1
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-
-
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2
-
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1
2
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1
-
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-
1
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438110
Munkres
Purification of exocellular su ...
Bacillus subtilis, Bos taurus, Escherichia coli, Saccharomyces cerevisiae, Triticum aestivum
Methods Enzymol.
186
249-260
1990
-
-
-
5
-
-
1
-
5
-
-
3
-
5
-
-
5
-
-
2
5
1
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
1
-
-
5
-
-
3
-
-
-
5
-
2
5
1
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438112
Amano
Characterization of superoxide ...
Porphyromonas gingivalis
J. Bacteriol.
172
1457-1463
1990
-
-
-
-
-
-
-
-
-
3
-
-
-
3
-
-
1
-
1
-
1
-
1
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-
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-
-
-
-
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-
-
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-
3
-
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-
-
-
1
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438120
Matsuda
Human liver manganese superoxi ...
Homo sapiens, Homo sapiens Mn-SOD
Eur. J. Biochem.
194
713-720
1990
-
-
-
1
-
2
2
-
-
1
2
-
-
5
-
-
1
-
-
2
1
1
2
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
2
-
2
-
-
-
1
2
-
-
-
-
1
-
2
1
1
2
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
438142
Capo
The Cu,Zn superoxide dismutase ...
Xenopus laevis
Biochem. Biophys. Res. Commun.
173
1186-1193
1990
-
-
-
-
-
-
-
-
-
2
-
-
-
3
-
-
1
1
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-
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-
1
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2
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438093
Wagner
Characterization of crystals o ...
Homo sapiens, Homo sapiens Mn-SOD
J. Mol. Biol.
206
787-788
1989
-
1
1
1
-
-
-
-
-
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1
-
-
5
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
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1
1
-
1
-
-
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-
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-
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-
1
-
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-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438095
Frigerio
Crystallographic characterizat ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae CuZn-SOD
Biochem. Biophys. Res. Commun.
160
677-681
1989
-
-
-
1
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438105
Vig
Purification and characterizat ...
Cyprinus carpio
Comp. Biochem. Physiol. B
94
395-397
1989
-
-
-
-
-
-
-
-
-
2
1
-
-
2
-
-
1
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
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-
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-
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-
-
-
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-
-
-
-
-
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2
1
-
-
-
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1
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438106
Sanchez-Moreno
Physico-chemical characteristi ...
Ascaris suum
Comp. Biochem. Physiol. B
92
737-740
1989
-
-
-
-
-
-
-
-
1
3
3
-
-
2
-
-
1
-
-
-
1
1
1
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
3
3
-
-
-
-
1
-
-
1
1
1
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
438119
Sanchez-Moreno
Superoxide dismutase in strain ...
Curtobacterium oceanosedimentum, Empedobacter brevis, Empedobacter brevis CCM 2867, Flavobacterium sp., Halomonas halmophila, Halomonas halmophila CCM 2833, Microbacterium maritypicum, Microbacterium maritypicum NCMB 559, Myroides odoratus, Myroides odoratus CCM 2873, Planomicrobium okeanokoites, Planomicrobium okeanokoites NCMB 561, Terrimonas ferruginea
Arch. Microbiol.
152
407-410
1989
-
-
-
-
-
-
-
-
-
16
2
-
-
16
-
-
1
-
-
-
8
2
13
-
-
-
11
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
2
-
-
-
-
1
-
-
8
2
13
-
-
-
11
-
-
-
1
-
-
-
-
-
-
-
438140
Lee
-
Purification and properties of ...
Bacillus circulans, Bacillus circulans Mn-SOD
Agric. Biol. Chem.
52
1361-1367
1988
-
-
-
-
-
-
-
-
-
1
2
-
-
2
-
-
1
-
-
-
1
-
2
1
-
-
1
-
-
-
2
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
1
-
-
1
-
2
1
-
-
1
-
-
-
2
-
-
-
-
-
-
-
438141
Salin
Purification of a manganese-co ...
Halobacterium salinarum, Halobacterium salinarum NRL
Arch. Biochem. Biophys.
260
806-810
1988
-
-
-
-
-
1
-
-
-
2
1
-
-
4
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662600
Takahashi
Changes in hepatic superoxide ...
Mus musculus
J. Med. Microbiol.
26
281-284
1988
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438118
Ishikawa
Isolation and characterization ...
Rattus norvegicus, Rattus norvegicus Mn-SOD
Eur. J. Biochem.
170
317-323
1987
-
-
-
-
-
-
1
-
1
1
2
-
-
6
-
-
1
-
-
2
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
1
2
-
-
-
-
1
-
2
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438139
Tsukuda
-
Isolation and characterization ...
Gluconobacter cerinus
Agric. Biol. Chem.
51
3323-3329
1987
-
-
-
-
-
1
-
-
-
1
2
-
-
1
-
-
1
-
-
-
1
-
1
1
-
-
2
-
1
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
2
-
-
-
-
1
-
-
1
-
1
1
-
-
2
-
1
1
1
-
-
-
-
-
-
-
438117
Kwiatowski
-
Isolation and characterization ...
Solanum lycopersicum
Biochim. Biophys. Acta
874
99-115
1986
-
-
-
-
-
1
2
-
2
2
3
-
-
1
-
-
1
-
-
1
1
-
1
1
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
2
2
3
-
-
-
-
1
-
1
1
-
1
1
-
-
2
-
1
-
-
-
-
-
-
-
-
-
438121
Parge
Crystallographic characterizat ...
Homo sapiens, Homo sapiens CuZn-SOD
J. Biol. Chem.
261
16215-16218
1986
-
-
1
1
-
-
-
-
-
-
-
-
-
13
-
-
1
-
-
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2
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1
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1
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1
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2
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438097
Cass
-
Superoxide dismutases ...
Bos taurus, Bos taurus CuZn-SOD, Caulobacter vibrioides, Caulobacter vibrioides CB15, Caulobacter vibrioides CuZn-SOD, Escherichia coli, Escherichia coli Fe-SOD, Escherichia coli Mn-SOD, Geobacillus stearothermophilus, Geobacillus stearothermophilus Mn-SOD, Photobacterium leiognathi, Photobacterium leiognathi CuZn-SOD, Propionibacterium freudenreichii subsp. shermanii, Saccharomyces cerevisiae, Saccharomyces cerevisiae CuZn-SOD, Saccharomyces cerevisiae Mn-SOD
Top. Mol. Struct. Biol.
6
121-156
1985
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-
-
1
1
-
1
-
7
27
7
16
-
41
-
-
-
6
1
1
-
-
16
6
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
1
1
-
-
1
1
-
7
27
7
16
-
-
-
-
1
1
-
-
16
6
-
-
-
-
1
-
-
-
-
-
-
-
-
-
438131
Asayama
Rat superoxide dismutases. Pur ...
Rattus norvegicus, Rattus norvegicus CuZn-SOD, Rattus norvegicus Mn-SOD
J. Biol. Chem.
260
2212-2217
1985
-
-
-
-
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1
-
-
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3
2
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7
-
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1
-
-
1
1
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
2
-
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-
-
1
-
1
1
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438132
Hoshino
The effect of sulfhydryl compo ...
Rattus norvegicus, Rattus norvegicus CuZn-SOD
Experientia
41
1416-1419
1985
1
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2
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3
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1
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1
1
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4
-
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1
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2
-
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1
-
1
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438138
Federico
Superoxide dismutase from Lens ...
Lens culinaris, Lens culinaris CuZn-SOD
Plant Physiol.
78
357-358
1985
-
-
-
-
-
-
-
-
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2
1
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4
-
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1
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5
1
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2
1
-
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-
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2
1
-
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1
-
5
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438145
Hayakawa
Purification and characterizat ...
Spinacia oleracea, Spinacia oleracea Mn-SOD
Planta
166
111-116
1985
-
-
-
-
-
-
2
-
1
1
2
-
-
3
-
-
1
1
-
1
1
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2
1
-
-
-
-
-
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-
-
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-
-
-
-
-
-
2
-
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1
1
2
-
-
-
-
1
-
1
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438157
Kwiatowski
Isolation and characterization ...
Solanum lycopersicum, Solanum lycopersicum Fe-SOD
Eur. J. Biochem.
146
459-466
1985
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-
-
-
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1
2
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1
2
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7
-
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1
1
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1
1
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2
1
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-
2
-
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-
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1
-
2
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1
2
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1
-
1
1
-
2
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
438161
Gregory
Characterization of the O2-ind ...
Bacteroides fragilis
Arch. Biochem. Biophys.
238
83-89
1985
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-
-
-
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1
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2
2
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3
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1
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1
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1
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1
1
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1
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2
2
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1
1
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
438162
Duke
Purification and characterizat ...
Ginkgo biloba
Arch. Biochem. Biophys.
243
305-314
1985
-
-
-
-
-
-
2
-
2
4
1
-
4
8
-
-
1
1
-
3
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
4
1
-
4
-
-
1
-
3
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438098
Bannister
Isolation and characterization ...
Homo sapiens, Homo sapiens CuZn-SOD, Photobacterium leiognathi, Pseudomonas putida
Methods Enzymol.
105
88-93
1984
-
-
-
-
-
-
-
-
2
-
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1
13
-
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2
-
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2
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4
-
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2
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1
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2
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438099
Flohe
Superoxide dismutase assays ...
Bos taurus, Homo sapiens, Homo sapiens CuZn-SOD
Methods Enzymol.
105
93-104
1984
-
-
-
-
-
-
-
-
-
-
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12
-
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2
-
3
-
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-
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-
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-
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2
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438100
Geller
Subcellular distribution of su ...
Rattus norvegicus
Methods Enzymol.
105
105-121
1984
-
-
-
-
-
-
-
-
3
-
-
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1
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1