Cloned (Comment) | Organism |
---|---|
recombinant expression in Mus musculus, CX3CR1-GFP mice, heterogenic parabiosis between mutant and wild-type mice confers a significant protection to wild-type mice, whereas mice with R213G knock-in mutation, a human single nucleotide polymorphism leading to reduced binding EcSOD in peripheral organs, exacerbate the organ damages. Recombinant EcSOD overexpressed in skeletal muscle-specific mutant mice redistributes to other peripheral organs through the circulation and enriches at the endothelium of the vasculatures. Mutant mice are resistant to endotoxemia (induced by lipopolysaccharide injection) in developing MODS with significantly reduces mortality and organ damages compared with the wild-type littermates | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
R213G | site-directed mutagenesis, mutant mice with R213G knock-in mutation, a human single nucleotide polymorphism leading to reduced binding EcSOD in peripheral organs, exacerbate the organ damages. Phenotype, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus C57BL/6J | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | muscle-derived extracellular superoxide dismutase | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
ECSOD | - |
Mus musculus |
extracellular superoxide dismutase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | enhanced EcSOD expression in skeletal muscle inhibits endothelial activation, EcSOD is sufficient to inhibit endothelial activation in vitro and in vivo | Mus musculus |
physiological function | EcSOD inhibits vascular cell adhesion molecule 1 expression and inflammatory leukocyte adhesion to the vascular wall of vital organs, blocking an early step of the pathology in organ damage under endotoxemia. Enhanced expression of EcSOD in skeletal muscle profoundly protects against Multiple organ dysfunction syndrome (MODS) by inhibiting endothelial activation and inflammatory cell adhesion, which might be a promising therapy for MODS | Mus musculus |