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Literature summary for 1.15.1.1 extracted from

  • Smolik, A.C.; Bengez-Pudja, L.; Cheng, I.; Mascotti, D.P.
    Characterization of E. coli manganese superoxide dismutase binding to RNA and DNA (2014), Biochim. Biophys. Acta, 1844, 2251-2256 .
    View publication on PubMed
Search for more literature for 1.15.1.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information thermodynamics, dissociation constants, and kinetics of RNA binding by enzyme MnSOD at pH 6.0-7.5 Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the bacterial manganese superoxide dismutase (MnSOD) localizes to the chromosomal portion of the cell Escherichia coli
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ a MnSOD Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 superoxide + 2 H+ Escherichia coli
-
 O2 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 superoxide + 2 H+
-
 Escherichia coli O2 + H2O2
-
 ?
additional information equilibrium binding of Escherichia coli MnSOD to poly(U), poly(A), poly(C), poly(dU) and double-stranded (ds) DNA, overview. The polynucleotides bind to MnSOD in the following affinity hierarchy, poly(dU) N poly(U) N dsDNA N poly(A) N poly(C). The differences in the hierarchy are not large in magnitude as the poly(dU) bound with less than a 100fold higher affinity than poly(C). For each polynucleotide, Kobs decreases only slightly with increasing [K+], surprising for a relatively non-specific nucleic acid protein. There is either only one binding site shared by these polynucleotides or the larger site size occluded by poly(C) overlaps that of poly(U) and poly(A), but extends further on the protein Escherichia coli ?
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Escherichia coli

Synonyms

Synonyms Comment Organism
manganese superoxide dismutase
-
 Escherichia coli
MnSOD
-
 Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 7.5 assay at Escherichia coli

General Information

General Information Comment Organism
physiological function the bacterial manganese superoxide dismutase (MnSOD) localizes to the chromosomal portion of the cell and impart protection from ionizing radiation to DNA. MnSOD can bind to RNA leads to the possibility that MnSOD may confer protection to RNA, as well Escherichia coli