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Literature summary for 1.15.1.1 extracted from

  • Barnese, K.; Sheng, Y.; Stich, T.A.; Gralla, E.B.; Britt, R.D.; Cabelli, D.E.; Valentine, J.S.
    Investigation of the highly active manganese superoxide dismutase from Saccharomyces cerevisiae (2010), J. Am. Chem. Soc., 132, 12525-12527.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.15.1.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information rate constants and kinetics compared to other SODs from other species, overview Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
-
 Saccharomyces cerevisiae 5759
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn Mn-SOD Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 O2.- + 2 H+ + Saccharomyces cerevisiae
-
 O2 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 yeast Mn-SOD shows high activity compared to other species' enzymes Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 O2.- + 2 H+ +
-
 Saccharomyces cerevisiae O2 + H2O2
-
 ?

Subunits

Subunits Comment Organism
homotetramer
-
 Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
manganese superoxide dismutase
-
 Saccharomyces cerevisiae
MnSOD
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function manganese superoxide dismutase enzymes catalyze superoxide disproportionation by a mechanism that is more complex than those of the other SOD types. In particular the reduction of superoxide can proceed via one of two pathways. One pathway dominates when the O2- concentration is low relative to the enzyme concentration, and the other pathway dominates when the ratio [O2-]/[MnSOD] is high, overview Saccharomyces cerevisiae