Cloned (Comment) | Organism |
---|---|
Cu,Zn-SOD, expression of wild-type and mutant in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D90A | Cu,Zn-SOD, mutant found in familial amyotrophic lateral sclerosis, activity similar compared to native and recombinant wild-type, but enhanced OH- generating activity, mutant is more sensitive to inhibition by copper-chelators | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diethyldithiocarbamate | copper-chelator, wild-type and mutant Cu,Zn-SOD | Homo sapiens | |
Penicillamine | copper-chelator, wild-type and mutant Cu,Zn-SOD | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | - |
Homo sapiens | |
Zn2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
Cu,Zn-SOD | - |
Homo sapiens CuZn-SOD | - |
Cu,Zn-SOD | - |
Purification (Comment) | Organism |
---|---|
Cu,Zn-SOD wild-type and mutant recombinant from Escherichia coli | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
O2- + H+ | - |
Homo sapiens | O2 + H2O2 | - |
r | |
O2- + H+ | - |
Homo sapiens CuZn-SOD | O2 + H2O2 | - |
r |
Subunits | Comment | Organism |
---|---|---|
? | x * 15764-15809, Cu,Zn-SOD wild-type and mutant D90A, electrospray mass spectroscopy | Homo sapiens |