Any feedback?
Literature summary for 1.14.99.66 extracted from
- FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure (2012), Nat. Commun., 3, 758 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q6ZQ88 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| KDM1A | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the inhibition of LSD1 activates energy-expenditure genes by transcriptional and epigenetic mechanisms in adipocytes. Disruption of LSD1 function results in the derepression of these genes leading to the activation of mitochondrial respiration and lipolysis in adipocytes. LSD1-mediated tranxadscriptional repression is FAD-dependent, and the disruption of cellular FAD synthesis exerts similar effects on the metabolic gene expression as the LSD1 inhibition. The expression of LSD1-target genes is markedly repressed in high fat-exposed white adipose tissue, and can be reverted by LSD1 inhibition | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
