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Literature summary for 1.14.99.66 extracted from

  • Tan, A.H.Y.; Tu, W.; McCuaig, R.; Hardy, K.; Donovan, T.; Tsimbalyuk, S.; Forwood, J.K.; Rao, S.
    Lysine-specific histone demethylase 1A regulates macrophage polarization and checkpoint molecules in the tumor microenvironment of triple-negative breast cancer (2019), Front. Immunol., 10, 1351 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
GSK2879552 inhibitor targets the FAD domain Mus musculus
Phenelzine inhibitor targets both the flavin adenine dinucleotide and CoREST binding domains of LSD1. Treatment reduces nuclear demethylase activity and increases transcription and expression of M1-like signatures both in vitro and in a murine triple-negative breast cancer model Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q6ZQ88
-
-

Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
-
 Mus musculus
-

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Mus musculus