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Literature summary for 1.14.99.66 extracted from
- FAD influx enhances neuronal differentiation of human neural stem cells by facilitating nuclear localization of LSD1 (2017), FEBS open bio, 7, 1932-1942 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | presence of FAD facilitates the nuclear localization of LSD1 | Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O60341 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neural stem cell | - |
Homo sapiens | - |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | FAD treatment of cells enables an increase in the amount of intracellular FAD and promotes neuronal differentiation of human neural stem cells derived from fetal brain or from induced pluripotent stem cells. Depression of FAD-dependent histone demethylase, lysine-specific demethylase-1 (LSD1), prevents FAD-induced neuronal differentiation. FAD influx facilitates nuclear localization of LSD1 and its enzymatic activity | Homo sapiens |  |
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Release 2023.1 (January 2023)
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