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Literature summary for 1.14.99.66 extracted from

  • Popova, E.Y.; Pinzon-Guzman, C.; Salzberg, A.C.; Zhang, S.S.; Barnstable, C.J.
    LSD1-mediated demethylation of H3K4me2 is required for the transition from late progenitor to differentiated mouse rod photoreceptor (2016), Mol. Neurobiol., 53, 4563-4581 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.66

Cloned(Commentary)

Cloned (Comment) Organism
gene KDM1A, quantitative real-time PCR enzyme expression analysis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
N-methyl-N-propargylbenzylamine hydrochloride i.e. pargyline Mus musculus
trans-2-phenylcyclopropylamine i.e. parnate or tranylcypromine, TCP Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for catalysis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 Mus musculus
-
 histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6-methyl-L-lysine4 + 2-oxoglutarate + O2 Mus musculus
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 histone H3 L-lysine4 + succinate + formaldehyde + CO2
-
 ?
additional information Mus musculus LSD1 demethylates mono- and dimethylated H3K4 and H3K9, but does not alter trimethylated H3K4 and H3K9 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q6ZQ88
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye
-
 Mus musculus
-
retina the highest expression of LSD1 occurs in postmitotic retinal cells during the peak period of rod photoreceptor differentiation. LSD1 appears to be absent at the outer margin of the retina, enzyme distribution, overview Mus musculus
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retinal pigment epithelium
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
 Mus musculus histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
 Mus musculus histone H3 L-lysine4 + succinate + formaldehyde + CO2
-
 ?
additional information LSD1 demethylates mono- and dimethylated H3K4 and H3K9, but does not alter trimethylated H3K4 and H3K9 Mus musculus ?
-
 ?
additional information no activity with histone H3 N6,N6,N6-dimethyl-L-lysine4 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
AOF2
-
 Mus musculus
H3K4me2/1 histone demethylase
-
 Mus musculus
KDM1A
-
 Mus musculus
LSD1
-
 Mus musculus
lysine-specific demethylase 1
-
 Mus musculus
More cf. [histone-H3]-lysine-9-demethylase Mus musculus

General Information

General Information Comment Organism
malfunction pharmacological inhibition of LSD1 in retinal explants cultured from PN1 to PN8 has three major effects. It prevents the normal decrease in expression of genes associated with progenitor function, it blocks rod photoreceptor development, and it increases expression of genes associated with other retinal cell types, e.g. genes Gnat2, Otop3, Pde6c, and Gnb3. Enzyme inhibition blocks rhodopsin expression in PN1 retinal explants, changes in rhodopsin expression caused by trans-2-phenylcyclopropylamine are not secondary to changes in cell proliferation or cell death. LSD1 enzyme inhibition changes the expression of many genes, but does not change the expression levels of these key regulators of retina development, microarrays, detailed overview Mus musculus
additional information LSD1 has no DNA-binding domain, LSD1 may interact with nuclear receptors NR2E1/ NR2E3 to bind to specific loci around progenitor genes and its promoters and that this binding is developmentally regulated Mus musculus
physiological function LSD1 is an enzyme active at key stages of development in a number of tissues, including the central nervous system. LSD1-mediated demethylation of H3K4me2 is required for the transition from late progenitor to differentiated mouse rod photoreceptor. LSD1 acts in concert with a series of nuclear receptors to modify chromatin structure and repress progenitor genes as well as to inhibit ectopic patterns of gene expression in the differentiating postmitotic retinal cells Mus musculus