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Literature summary for 1.14.99.66 extracted from

  • Nair, V.D.; Ge, Y.; Balasubramaniyan, N.; Kim, J.; Okawa, Y.; Chikina, M.; Troyanskaya, O.; Sealfon, S.C.
    Involvement of histone demethylase LSD1 in short-time-scale gene expression changes during cell cycle progression in embryonic stem cells (2012), Mol. Cell. Biol., 32, 4861-4876.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
LSD1 genome-wide mapping and expression analysis, LSD1 genomic regions overlap H3K4me2 regions, transcriptional corepressor LSD1 is enriched at the promoter regions of highly expressed genes in ES cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information genome-wide mapping and cellular localization studies of LSD1, transcriptional corepressor LSD1 is enriched at the promoter regions of highly expressed genes in ES cells Mus musculus
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nucleus
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Mus musculus 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 Mus musculus
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histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell R1 ES cells Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
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Mus musculus histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
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?

Synonyms

Synonyms Comment Organism
histone demethylase
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Mus musculus
LSD1
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Mus musculus

General Information

General Information Comment Organism
malfunction LSD1 knockdown by RNA interference or its displacement from the chromatin by antineoplastic agents caused an increase in the levels of a subset of LSD1 target genes Mus musculus
physiological function LSD1 is regulated in a cell cycle-dependent manner, overview. Histone demethylase LSD1, a component of the CoREST (corepressor for element 1-silencing transcription factor) corepressor complex, plays an important role in the downregulation of gene expression during development, correlation between the genomic levels of LSD1/H3K4me2 and gene expression, including many highly expressed ES cell genes, mechanisms underlying these two distinct functions of LSD1, overview. Cell cycle-dependent association and dissociation of LSD1 with chromatin mediates short-time-scale gene expression changes during embryonic stem cell cycle progression Mus musculus