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Literature summary for 1.14.99.66 extracted from

  • Yokoyama, A.; Takezawa, S.; Schuele, R.; Kitagawa, H.; Kato, S.
    Transrepressive function of TLX requires the histone demethylase LSD1 (2008), Mol. Cell. Biol., 28, 3995-4003.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
K661A inactive mutant Homo sapiens
additional information knockdown of either TLX or LSD1 derepresses expression of the endogenous PTEN gene and inhibits cell proliferation of Y79 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens LSD1 forms a complex with CoREST and histone deacetylase 1. LSD1 mediates the transrepressive function of TLX, an orphan nuclear receptor, also called NR2E1, that regulates the expression of target genes by functioning as a constitutive transrepressor, through direct interaction via its SWIRM and amine oxidase domains. Physiological significance of TLX in the cytodifferentiation of neural cells in the brain ?
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 Homo sapiens
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[histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
LSD1, i.e. KDM1
-

Source Tissue

Source Tissue Comment Organism Textmining
retinoblastoma cell
-
Homo sapiens
-
Y-79 cell retinoblastoma cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information LSD1 forms a complex with CoREST and histone deacetylase 1. LSD1 mediates the transrepressive function of TLX, an orphan nuclear receptor, also called NR2E1, that regulates the expression of target genes by functioning as a constitutive transrepressor, through direct interaction via its SWIRM and amine oxidase domains. Physiological significance of TLX in the cytodifferentiation of neural cells in the brain Homo sapiens ?
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
-
Homo sapiens [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
?

Synonyms

Synonyms Comment Organism
histone demethylase
-
Homo sapiens
KDM1
-
Homo sapiens
LSD1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function LSD1 acts as a prime corepressor for TLX, LSD1 interacts directly with TLX via its SWIRM and amine oxidase domains potentiating the transrepressive function of TLX through its histone demethylase activity. LSD1 and TLX are recruited to a TLX-binding site in the PTEN gene promoter, accompanied by the demethylation of H3K4me2 and deacetylation of H3 Homo sapiens