Cloned (Comment) | Organism |
---|---|
fragment consisting of residues 172-833, expression as glutathione S-transferase fusion protein in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
in complex with inhibitor tranylcypromine, diffraction to 2.25 A. In the inhibitor-free structure, a water molecule forms a hydrogen bond with the flavin N(5) atom and Lys661. The LSD1-tranylcypromine complex is not completely composed of the five-membered adduct, but partially contains an intermediate | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60341 | isoform LSD1 | - |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens |