Literature summary for 1.14.99.66 extracted from

Forneris, F.; Binda, C.; Vanoni, M.A.; Mattevi, A.; Battaglioli, E.
Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process (2005), FEBS Lett., 579, 2203-2207.

Search for more literature for 1.14.99.66

Cloned(Commentary)

Cloned (Comment)	Organism
two LSD1 truncated forms, lacking the first 157 and 184 amino acids, respectively, expression in Escherichia coli	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
two LSD1 truncated forms, lacking the first 157 and 184 amino acids, respectively	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dimethylated histone 3-Lys4 peptide + H2O	the enzyme specifically removes methyl groups from Lys4 of histone 3. The enzyme exhibits oxidase activity (with production of H2O2) but it can function also with a synthetic mono-electronic acceptor	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
LSD1	-	Homo sapiens
lysine-specific histone demethylase 1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
FAD	histone demethylation involves the enzyme-bound FAD cofactor	Homo sapiens

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Release 2023.1 (January 2023)