Literature summary for 1.14.99.60 extracted from

Tran, U.; Marbois, B.; Gin, P.; Gulmezian, M.; Jonassen, T.; Clarke, C.
Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide Two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis (2006), J. Biol. Chem., 281, 16401-16409 .

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Protein Variants

Protein Variants	Comment	Organism
E194K	mutation affects invariant residue predicted to function as ligands to the di-iron center. Mutant is respiratory defective, lacks coenzyme Q6, and accumulates relatively large amounts of demethoxycoenzyme Q6	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol + a reduced acceptor + O2	Saccharomyces cerevisiae	-	3-demethylubiquinol + acceptor + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol + a reduced acceptor + O2	-	Saccharomyces cerevisiae	3-demethylubiquinol + acceptor + H2O	-	?

General Information

General Information	Comment	Organism
physiological function	the Escherichia coli UbiF gene expressed at low copy restores growth of Coq7 point mutant E194K on medium containing a non-fermentable carbon source, but fails to rescue a coq7 null mutant. Expression of UbiF from a multicopy vector restores growth and coenzyme Q synthesis for both mutants, although with a higher efficiency in the point mutant. Addition of coenzyme Q to the growth media also stabilizes the Coq3 and Coq4 polypeptides in the coq7 null mutant	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)