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Literature summary for 1.14.99.52 extracted from

  • Bushnell, E.A.; Fortowsky, G.B.; Gauld, J.W.
    Model iron-oxo species and the oxidation of imidazole: insights into the mechanism of OvoA and EgtB? (2012), Inorg. Chem., 51, 13351-13356.
    View publication on PubMed
Search for more literature for 1.14.99.52

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information free-energy cost calculations for determining the catalytic mechanism, overview Erwinia tasmaniensis

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ a mononuclear non-heme iron enzyme, dependent on Erwinia tasmaniensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidine + L-cysteine + O2 Erwinia tasmaniensis
-
 S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O
-
 ?
L-histidine + L-cysteine + O2 Erwinia tasmaniensis DSM 17950
-
 S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Erwinia tasmaniensis B2VFD8 gene ovoA
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Erwinia tasmaniensis DSM 17950 B2VFD8 gene ovoA
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Reaction

Reaction Comment Organism Reaction ID
L-histidine + L-cysteine + O2 = S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O the catalytic mechanism proceeds via radical intermediate, oxidation of histidine is thermodynamically most favorable for the formation of a HisNdelta(-H). radical via a proton-coupled electron transfer process, only the ferrous peroxysulfur complexes are sufficiently powerful enough oxidants to generate a histidyl-derived radical, not the superoxo-complexes Erwinia tasmaniensis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine + L-cysteine + O2
-
 Erwinia tasmaniensis S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O
-
 ?
L-histidine + L-cysteine + O2 evaluation of the mechanistic feasibility of the various possible iron-oxygen oxidants in the proton-coupled electron transfer process or the electron transfer process, overview Erwinia tasmaniensis S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O
-
 ?
L-histidine + L-cysteine + O2
-
 Erwinia tasmaniensis DSM 17950 S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O
-
 ?
L-histidine + L-cysteine + O2 evaluation of the mechanistic feasibility of the various possible iron-oxygen oxidants in the proton-coupled electron transfer process or the electron transfer process, overview Erwinia tasmaniensis DSM 17950 S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
5-histidylcysteine sulfoxide synthase
-
 Erwinia tasmaniensis
OvoA
-
 Erwinia tasmaniensis