Any feedback?
Literature summary for 1.14.99.48 extracted from
- The flexible loop of Staphylococcus aureus IsdG is required for its degradation in the absence of heme (2011), Biochemistry, 50, 6730-6737.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Staphylococcus aureus | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | A6QG37 | - |
- |
| Staphylococcus aureus Newman | A6QG37 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| isdG | - |
Staphylococcus aureus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | in the absence of heme, isoform IsdG is targeted for degradation by internally coded sequences. A flexible loop near the heme-binding pocket is required for IsdG degradation in the absence of heme. IsdG stability is increased by inhibiting ATPases | Staphylococcus aureus |
| physiological function | in the vertebrate host, Staphylococcus aureus fulfills its iron requirement by obtaining heme-iron from host hemoproteins via IsdG- and IsdI-mediated heme degradation. Isoforms IsdG and IsdI are structurally and mechanistically analogous but are differentially regulated by iron and heme availability | Staphylococcus aureus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
