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Literature summary for 1.14.99.48 extracted from

  • Haley, K.P.; Janson, E.M.; Heilbronner, S.; Foster, T.J.; Skaar, E.P.
    Staphylococcus lugdunensis IsdG liberates iron from host heme (2011), J. Bacteriol., 193, 4749-4757.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.48

Activating Compound

Activating Compound Comment Organism Structure
Iron isoform IsdG is most abundant under iron-depleted conditions. The presence of heme has no effect on the intracellular abundance of IsdG Staphylococcus lugdunensis

Organism

Organism UniProt Comment Textmining
Staphylococcus lugdunensis A0A133QBY0
-
-
Staphylococcus lugdunensis N920143 A0A133QBY0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus lugdunensis 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O heme degradation by IsdG results in the release of free iron and the production of the chromophore staphylobilin, i.e. 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus lugdunensis N920143 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O heme degradation by IsdG results in the release of free iron and the production of the chromophore staphylobilin, i.e. 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus lugdunensis 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O heme degradation by IsdG results in the release of free iron and the production of the chromophore staphylobilin, i.e. 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus lugdunensis N920143 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O heme degradation by IsdG results in the release of free iron and the production of the chromophore staphylobilin, i.e. 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin ?

Synonyms

Synonyms Comment Organism
isdG
-
 Staphylococcus lugdunensis

General Information

General Information Comment Organism
physiological function isoform IsdG-mediated heme catabolism enables the use of heme as a sole source of iron Staphylococcus lugdunensis