Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.99.4 extracted from

  • Berrie, J.R.; Williams, R.A.D.; Smith, K.E.
    Purification and characterization of progesterone hydroxylase, cytochrome P-450 from Streptomyces roseochromogenes ATCC 13400 (1997), Biochem. Soc. Trans., 25, 18S.
    View publication on PubMed
Search for more literature for 1.14.99.4

Activating Compound

Activating Compound Comment Organism Structure
coumarin hydroxylase activity is amplifiable by coumarin, increases 50% above that found constitutively Streptomyces roseochromogenus

Inhibitors

Inhibitors Comment Organism Structure
ketoconazole
-
 Streptomyces roseochromogenus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
 PAGE, gel filtration Streptomyces roseochromogenus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
progesterone + NADPH + H+ + O2 Streptomyces roseochromogenus
-
 Testosterone acetate + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces roseochromogenus
-
 ATCC 13400
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptomyces roseochromogenus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
progesterone + NADPH + H+ + O2
-
 Streptomyces roseochromogenus Testosterone acetate + NADP+ + H2O
-
 ?
progesterone + NADPH + H+ + O2
-
 Streptomyces roseochromogenus 16alpha-hydroxyprogesterone + 2beta,16alpha-dihydroxyprogesterone + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cytochrome P-450/monooxygenase
-
 Streptomyces roseochromogenus

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
 Streptomyces roseochromogenus