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Literature summary for 1.14.99.38 extracted from

  • Russell, D.W.
    Oxysterol biosynthetic enzymes (2000), Biochim. Biophys. Acta, 1529, 126-135.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Mus musculus
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
Golgi apparatus
-
Homo sapiens 5794
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe diiron-containing enzyme. The iron is present as Fe-O-Fe or Fe-OH-Fe and is coordinated with clusters of conserved histidine residues Mus musculus
Fe diiron-containing enzyme. The iron is present as Fe-O-Fe or Fe-OH-Fe and is coordinated with clusters of conserved histidine residues Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31700
-
x * 31700 Homo sapiens
34700
-
x * 34700 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + AH2 + O2 Mus musculus the enzyme has the capacity to synthesize an active and potent regulator of the sterol response element binding protein pathway within the cell 25-hydroxycholesterol + A + H2O
-
?
cholesterol + AH2 + O2 Homo sapiens the enzyme has the capacity to synthesize an active and potent regulator of the sterol response element binding protein pathway within the cell 25-hydroxycholesterol + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O95992
-
-
Mus musculus Q9Z0F5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Mus musculus
-
kidney
-
Mus musculus
-
lung
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + AH2 + O2 the enzyme has the capacity to synthesize an active and potent regulator of the sterol response element binding protein pathway within the cell Mus musculus 25-hydroxycholesterol + A + H2O
-
?
cholesterol + AH2 + O2 the enzyme has the capacity to synthesize an active and potent regulator of the sterol response element binding protein pathway within the cell Homo sapiens 25-hydroxycholesterol + A + H2O
-
?

Subunits

Subunits Comment Organism
? x * 31700 Homo sapiens
? x * 34700 Mus musculus