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Literature summary for 1.14.99.29 extracted from

  • Caceres, C.J.; Angulo, J.; Contreras, N.; Pino, K.; Vera-Otarola, J.; Lopez-Lastra, M.
    Targeting deoxyhypusine hydroxylase activity impairs cap-independent translation initiation driven by the 5'untranslated region of the HIV-1, HTLV-1, and MMTV mRNAs (2016), Antiviral Res., 134, 192-206 .
    View publication on PubMed
Search for more literature for 1.14.99.29

Inhibitors

Inhibitors Comment Organism Structure
ciclopirox
-
 Homo sapiens
deferiprone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[eIF5A]-deoxyhypusine + AH2 + O2 Homo sapiens
-
 [eIF5A]-hypusine + A + H2O
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BU89
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[eIF5A]-deoxyhypusine + AH2 + O2
-
 Homo sapiens [eIF5A]-hypusine + A + H2O
-
 ir

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
deoxyhypusine hydroxylase
-
 Homo sapiens
DOHH
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the cellular concentration of the enzyme and its enzymatic activity play a role in HIV-1, HTLV-1 and MMTV IRES-mediated translation initiation Homo sapiens