Cloned (Comment) | Organism |
---|---|
gene dohh, quantitative expression analysis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
mimosine | synergistic growth inhibition with the combination of miR-331-3p and miR-642-5p and mimosine | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[eIF5A]-deoxyhypusine + AH2 + O2 | Homo sapiens | - |
[eIF5A]-hypusine + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BU89 | gene dohh, substrain PEXT-1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
22Rv-1 cell | - |
Homo sapiens | - |
DU-145 cell | - |
Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
LNCAP-C4-2B cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
prostate gland epithelium | - |
Homo sapiens | - |
RWPE-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[eIF5A]-deoxyhypusine + AH2 + O2 | - |
Homo sapiens | [eIF5A]-hypusine + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
deoxyhypusine hydroxylase | - |
Homo sapiens |
DOHH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | transient overexpression of micro-RNA miR-331-3p and/or miR-642-5p in DU-145 prostate cancer cells reduces DOHH mRNA and protein expression and inhibits cell proliferation | down |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme catalyzes the activation of eukaryotic translation initiation factor, eIF5A, a protein essential for cell growth. Expression of DOHH is regulated by micro-RNAs miR-331-3p and miR-642-5p in prostate cancer cells, overview. Transient overexpression of miR-331-3p and/or miR-642-5p in DU-145 prostate cancer cells reduces DOHH mRNA and protein expression and inhibits cell proliferation | Homo sapiens |