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Literature summary for 1.14.99.24 extracted from

  • Mutafov, S.; Angelova, B.; Avramova, T.; Boyadjieva, L.; Dimova, I.
    The inducibility of 9alpha-steroid hydroxylating activity in resting Rhodococcus sp. cells (1997), Process Biotechnol., 32, 585-589.
No PubMed abstract available
Search for more literature for 1.14.99.24

Activating Compound

Activating Compound Comment Organism Structure
ethanol presence of ethanol enhances the hydroxylation by resting non-induced cells Rhodococcus sp.

Application

Application Comment Organism
medicine
-
 Corynebacterium sp.
medicine 9alpha-steroid hydroxylating activity is used for conversion of different steroid compounds into valuable 9alpha-hydroxy derivatives used in the pharmaceutical industry Rhodococcus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4,9(11)-pregnadiene-3,20-dione + NADH + O2 Corynebacterium sp.
-
 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
 ?
4,9(11)-pregnadiene-3,20-dione + NADH + O2 Rhodococcus sp. key enzyme system controlling the microbial 9alpha-hydroxylation of 4-androstene-3,17-dione 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
 ?
4,9(11)-pregnadiene-3,20-dione + NADH + O2 Rhodococcus sp. IOC-77 key enzyme system controlling the microbial 9alpha-hydroxylation of 4-androstene-3,17-dione 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Corynebacterium sp.
-
 synonym Nocardia restrictus, ATCC 14887 (MCI 1354)
-
Rhodococcus sp.
-
-
-
Rhodococcus sp. IOC-77
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4,9(11)-pregnadiene-3,20-dione + NADH + O2
-
 Corynebacterium sp. 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
 ?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
-
 Rhodococcus sp. 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
 ?
4,9(11)-pregnadiene-3,20-dione + NADH + O2 key enzyme system controlling the microbial 9alpha-hydroxylation of 4-androstene-3,17-dione Rhodococcus sp. 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
 ?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
-
 Rhodococcus sp. IOC-77 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
 ?
4,9(11)-pregnadiene-3,20-dione + NADH + O2 key enzyme system controlling the microbial 9alpha-hydroxylation of 4-androstene-3,17-dione Rhodococcus sp. IOC-77 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
 ?
4-androstene-3,17-dione + NADH + O2
-
 Corynebacterium sp. 9alpha-hydroxy-4-androstene-3,17-dione + NAD+ + H2O
-
 ?
4-androstene-3,17-dione + NADH + O2
-
 Rhodococcus sp. 9alpha-hydroxy-4-androstene-3,17-dione + NAD+ + H2O
-
 ?
4-androstene-3,17-dione + NADH + O2
-
 Rhodococcus sp. IOC-77 9alpha-hydroxy-4-androstene-3,17-dione + NAD+ + H2O
-
 ?