Literature summary for 1.14.99.24 extracted from

Kang, H.K.; Lee, S.S.
Microbial 9alpha-hydroxylase: epoxidation of 9(11)-dehydro-17a-methyl-testosterone (1997), Arch. Pharm. Res., 20, 525-528.

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Application

Application	Comment	Organism
medicine	enzyme catalyzes the production of 9alpha-hydroxy-4-androstene-3,17-dione, an important intermediate for the semi-synthesis of potent anti-inflammatory drugs such as 9alpha-fluorocorticoids from 4-androstene-3,17-dione	Corynebacterium sp.
synthesis	steroid 9alpha-hydroxylase in company with delta-dehydrogenase is used in industrial processes	Corynebacterium sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4,9(11)-pregnadiene-3,20-dione + NADH + O2	Corynebacterium sp.	key enzyme system in steroid nucleus degradation in company with delta-dehydrogenase	9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Corynebacterium sp.	-	synonym Nocardia restrictus, ATCC 14887 (MCI 1354)	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4,9(11)-pregnadiene-3,20-dione + NADH + O2	-	Corynebacterium sp.	9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O	-	?
4,9(11)-pregnadiene-3,20-dione + NADH + O2	key enzyme system in steroid nucleus degradation in company with delta-dehydrogenase	Corynebacterium sp.	9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O	-	?
9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2	-	Corynebacterium sp.	9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O	-	?

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Release 2023.1 (January 2023)