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Literature summary for 1.14.99.22 extracted from

  • Kong, Y.; Liu, X.P.; Wan, P.J.; Shi, X.Q.; Guo, W.C.; Li, G.Q.
    The P450 enzyme Shade mediates the hydroxylation of ecdysone to 20-hydroxyecdysone in the Colorado potato beetle, Leptinotarsa decemlineata (2014), Insect Mol. Biol., 23, 632-643 .
    View publication on PubMed
Search for more literature for 1.14.99.22

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Leptinotarsa decemlineata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ecdysone + reduced acceptor + O2 Leptinotarsa decemlineata
-
 20-hydroxyecdysone + acceptor + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Leptinotarsa decemlineata V5K5L7 Colorado potato beetle
-

Source Tissue

Source Tissue Comment Organism Textmining
adult
-
 Leptinotarsa decemlineata
-
egg
-
 Leptinotarsa decemlineata
-
larva
-
 Leptinotarsa decemlineata
-
pupa
-
 Leptinotarsa decemlineata
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ecdysone + reduced acceptor + O2
-
 Leptinotarsa decemlineata 20-hydroxyecdysone + acceptor + H2O
-
 ?

Synonyms

Synonyms Comment Organism
Cyp314A1
-
 Leptinotarsa decemlineata
E20MO
-
 Leptinotarsa decemlineata
ecdysone 20-monooxygenase
-
 Leptinotarsa decemlineata
shade
-
 Leptinotarsa decemlineata
shd
-
 Leptinotarsa decemlineata

Cofactor

Cofactor Comment Organism Structure
heme
-
 Leptinotarsa decemlineata

General Information

General Information Comment Organism
malfunction enzyme knockdown causes larval lethality, delayed development and affects pupation Leptinotarsa decemlineata