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Literature summary for 1.14.99.1 extracted from

  • Li, N.; Wang, Q.; Zhu, T.; Qiao, L.; Zhang, F.; Mi, R.; Wang, B.; Chen, L.; Gu, J.; Lu, Y.; Zheng, Q.
    In vitro functional characterization of prostaglandin-endoperoxide synthase 2 during chondrocyte hypertrophic differentiation (2016), Oncotarget, 7, 36280-36292 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.1

Inhibitors

Inhibitors Comment Organism Structure
NS398
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ATDC-5 cell
-
 Mus musculus
-
chondrocyte
-
 Mus musculus
-
chondrogenic MCT cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
COX-2
-
 Mus musculus
cyclooxygenase 2
-
 Mus musculus
prostaglandin-endoperoxide synthase 2
-
 Mus musculus
PTGS2
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme promotes Col10a1 expression and enhances hypertrophic differentiation of ATDC5 cells. Cox-2 also upregulates marker genes of chondrocyte maturation, apoptosis, and matrix mineralization, including transcription factors Runx2, Alp, Bsp, and Osterix Mus musculus