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Literature summary for 1.14.99.1 extracted from

  • Censarek, P.; Freidel, K.; Hohlfeld, T.; Schroer, K.; Weber, A.A.
    Human cyclooxygenase-1b is not the elusive target of acetaminophen (2006), Eur. J. Pharmacol., 551, 50-53.
    View publication on PubMed
Search for more literature for 1.14.99.1

Application

Application Comment Organism
medicine inhibition of cyclooxygenases is a mode of antiinflammatory drugs Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
for transfection of COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
cyclooxygenase-1bdeltaG mutant, in which the frame shift in the splice variant human cyclooxygenase-1b is corrected Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
aspirin
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
 human cyclooxygenase-1, estimated by SDS-PAGE and Western blotting, detected with a cyclooxygenase-1 antibody Homo sapiens
72000
-
 human cyclooxygenase-1bdeltaG, estimated by SDS-PAGE and Western blotting, detected with a cyclooxygenase-1 and a FLAG-tag antibody Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + AH2 + O2 Homo sapiens
-
 prostaglandin H2 + A + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + AH2 + O2
-
 Homo sapiens prostaglandin H2 + A + H2O
-
 ?
arachidonic acid + AH2 + 2 O2 activity assay Homo sapiens 6-keto-prostaglandin F1alpha + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cyclooxygenase-1b cyclooxygenase-1 splice variant Homo sapiens