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Literature summary for 1.14.99.1 extracted from
- Kinetic mechanism of the bifunctional enzyme prostaglandin-H-synthase. Effect of electron donors on the cyclooxygenase reaction (2006), Biochemistry (Moscow), 71, 1247-1255.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| naproxen | inhibitor of cyclooxigenase reaction; inhibitor of cyclooxigenase reaction | Ovis aries |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Ovis aries | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 72000 | - |
monomer | Ovis aries |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + AH2 + O2 | Ovis aries | - |
prostaglandin H2 + A + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | P05979 | PGHS-1 precursor | - |
| Ovis aries | P79208 | PGHS-2 precursor | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + AH2 + O2 | - |
Ovis aries | prostaglandin H2 + A + H2O | - |
? | |
| arachidonic acid + 2 O2 | cyclooxygenase reaction, arachidonic acid as electron donor | Ovis aries | prostaglandin G2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Ovis aries |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PGHS | - |
Ovis aries |
| PGHS-1 | one of two isoforms found in mammalian cells, always present and provides their normal functioning | Ovis aries |
| PGHS-2 | one of two isoforms found in mammalian cells, produced in response to certain stimuli, such as cytokines and growth factors | Ovis aries |
| prostaglandin-endoperoxide synthase | - |
Ovis aries |
| prostaglandin-H-synthase | - |
Ovis aries |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
kinetic assay | Ovis aries |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
kinetic assay | Ovis aries |
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Release 2023.1 (January 2023)
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