Literature summary for 1.14.20.9 extracted from

Clarke-Pearson, M.; Brady, S.
Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa (2008), J. Bacteriol., 190, 6927-6930 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2	Pseudomonas aeruginosa	-	(2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + succinate + CO2 + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2	-	Pseudomonas aeruginosa	(2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + succinate + CO2 + H2O	-	?

Synonyms

Synonyms	Comment	Organism
pvcB	-	Pseudomonas aeruginosa

General Information

General Information	Comment	Organism
physiological function	in the biosynthetis of paerucumarin, PvcA generates an isonitrile-functionalized tyrosine, (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate, that is oxidized by PvcB to give the unsaturated intermediate compound (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate. Oxidation of this compound to a catechol by PvcC/D, followed by intermolecular cyclization of the catechol and the carboxylate, gives paerucumarin. Pseudomonas aeruginosa strains produced a different ratio of paerucumarin to pseudoverdine. PAO1 produces almost exclusively paerucumarin, while PA14 produces approximately a one-to-one mixture of paerucumarin and pseudoverdine	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)