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Literature summary for 1.14.20.6 extracted from

  • Halbwirth, H.; Fischer, T.C.; Schlangen, K.; Rademacher, W.; Schleifer, K.; Forkmann, G.; Stich, K.
    Screening for inhibitors of 2-oxoglutarate-dependent dioxygenases: Flavanone 3?-hydroxylase and flavonol synthase (2006), Plant Sci., 171, 194-205.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
piperazine-1,4-bis-(2-ethane sulfonic acid) 1 mM, 115% activity Pyrus communis
piperazine-1,4-bis-(2-ethane sulphonic acid) 1 mM, 115% activity Malus domestica
pyridine-2,3-dicarboxylic acid 1 mM 171% activity, 0.1 mM 115% activity Malus domestica
pyridine-2,3-dicarboxylic acid 1 mM 171% activity, 0.1 mM 115% activity Pyrus communis
pyridine-2,6-dicarboxylic acid 1 mM 150% activity, 0.1 mM 144% activity Malus domestica
pyridine-2,6-dicarboxylic acid 1 mM 150% activity, 0.1 mM 144% activity Pyrus communis
pyridine-2,6-dicarboxylic acid chloride 1 mM, 120% activity Malus domestica
pyridine-2,6-dicarboxylic acid chloride 1 mM, 120% activity Pyrus communis
pyridine-3,5-dicarboxylic acid 1 mM, 128% activity Malus domestica
pyridine-3,5-dicarboxylic acid 1 mM, 128% activity Pyrus communis
pyrrole-3,4-dicarboxylic acid diethyl ester 1 mM, 113% activity Malus domestica
pyrrole-3,4-dicarboxylic acid diethyl ester 1 mM, 113% activity Pyrus communis
sorbitol 0.6 mM Malus domestica
sorbitol 0.6 mM Pyrus communis

Inhibitors

Inhibitors Comment Organism Structure
3-hydroxy-5-oxo-4-butyryl-cyclohex-3-ene-1-carboxylic acid ethyl ester 1 mM 48% activity, 0.1 mM 88% activity Malus domestica
3-hydroxy-5-oxo-4-butyryl-cyclohex-3-ene-1-carboxylic acid ethyl ester 1 mM 48% activity, 0.1 mM 88% activity Pyrus communis
3-hydroxy-5-oxo-4-cyclopropanecarbonyl-cyclohex-3-ene-1-carboxylic acid ethyl ester 1 mM 50% activity, 0.1 mM 77% activity Malus domestica
3-hydroxy-5-oxo-4-cyclopropanecarbonyl-cyclohex-3-ene-1-carboxylic acid ethyl ester 1 mM 50% activity, 0.1 mM 77% activity Pyrus communis
3-hydroxy-5-oxo-4-propionyl-cyclohex-3-ene-1-(2-dimethylamino)-thiazole 1 mM 44% activity, 0.1 mM 73% activity Malus domestica
3-hydroxy-5-oxo-4-propionyl-cyclohex-3-ene-1-(2-dimethylamino)-thiazole 1 mM 44% activity, 0.1 mM 73% activity Pyrus communis
3-hydroxy-5-oxo-4-propionyl-cyclohex-3-ene-1-carbaldehyde 1 mM 56% activity, 0.1 mM 82% activity Malus domestica
3-hydroxy-5-oxo-4-propionyl-cyclohex-3-ene-1-carbaldehyde 1 mM 56% activity, 0.1 mM 82% activity Pyrus communis
3-hydroxy-5-oxo-4-propionyl-cyclohex-3-ene-1-carbothioic acid S-ethyl ester 1 mM 33% activity, 0.1 mM 90% activity Malus domestica
3-hydroxy-5-oxo-4-propionyl-cyclohex-3-ene-1-carbothioic acid S-ethyl ester 1 mM 33% activity, 0.1 mM 90% activity Pyrus communis
3-hydroxy-5-oxo-4-propionyl-cyclohex-3-ene-1-pentanoic acid 1 mM 23% activity, 0.1 mM 64% activity Malus domestica
3-hydroxy-5-oxo-4-propionyl-cyclohex-3-ene-1-pentanoic acid 1 mM 23% activity, 0.1 mM 64% activity Pyrus communis
benzene-1,2,4,5-tetracarboxylic acid 1 mM 95% activity Malus domestica
benzene-1,2,4,5-tetracarboxylic acid 1 mM 95% activity Pyrus communis
calcium 3-hydroxy-5-oxo-4-propionyl-cyclohex-3-ene-1-carboxylate 1 mM 11% activity, 0.1 mM 29% relative activity Malus domestica
calcium 3-hydroxy-5-oxo-4-propionyl-cyclohex-3-ene-1-carboxylate 1 mM 11% activity, 0.1 mM 29% activity Pyrus communis
pyrazole-3,5-dicarboxylic acid 1 mM 22% activity, 0.1 mM 79% activity Malus domestica
pyrazole-3,5-dicarboxylic acid 1 mM 22% activity, 0.1 mM 79% activity Pyrus communis
pyridine-2,4-dicarboxylic acid diethyl ester 1 mM 3% activity, 0.1 mM 13% activity Malus domestica
pyridine-2,4-dicarboxylic acid diethyl ester 1 mM 3% activity, 0.1 mM 13% activity Pyrus communis
pyridine-2,5-dicarboxylic acid 1 mM 3% activity, 0.1 mM 11% activity Malus domestica
pyridine-2,5-dicarboxylic acid 1 mM 3% activity, 0.1 mM 11% activity Pyrus communis
pyridine-3,4-dicarboxylic acid 1 mM 86% activity, 0.1 mM 85% activity Malus domestica
pyridine-3,4-dicarboxylic acid 1 mM 86% activity, 0.1 mM 85% activity Pyrus communis
sodium 4,6-dioxo-2,2-dimethyl-5-(1-alloxyamino-butylidene)-cyclohexane-1-carboxylic acid methyl ester 1 mM 78% activity, 0.1 mM 84% activity Malus domestica
sodium 4,6-dioxo-2,2-dimethyl-5-(1-alloxyamino-butylidene)-cyclohexane-1-carboxylic acid methyl ester 1 mM 78% activity, 0.1 mM 84% activity Pyrus communis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
dihydrokaempferol in 0.1 M K2HPO4/KH2PO4 (0.6 M sorbitol, 0.4% Na-ascorbate, pH 7.25) with 0.095 nmol dihydrokaempferol, 50 nmol 2-oxoglutarate and 10 nmol FeSO4 hydrate at 30°C Pyrus communis
0.001
-
dihydrokaempferol in 0.1 M K2HPO4/KH2PO4 (0.6 M sorbitol, 0.4% Na-ascorbate, pH 7.25), 50 nmol 2-oxoglutarate and 10 nmol FeSO4 hydrate at 30°C Malus domestica
0.0012
-
dihydroquercetin in 0.1 M K2HPO4/KH2PO4 (0.6 M sorbitol, 0.4% Na-ascorbate, pH 7.25) with 0.095 nmol dihydrokaempferol, 50 nmol 2-oxoglutarate and 10 nmol FeSO4 hydrate at 30°C Malus domestica
0.0012
-
dihydroquercetin in 0.1 M K2HPO4/KH2PO4 (0.6 M sorbitol, 0.4% Na-ascorbate, pH 7.25) with 0.095 nmol dihydrokaempferol, 50 nmol 2-oxoglutarate and 10 nmol FeSO4 hydrate at 30°C Pyrus communis

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Malus domestica
Fe2+ required Pyrus communis

Organism

Organism UniProt Comment Textmining
Malus domestica
-
cultivars M9 and Weirouge
-
Pyrus communis
-
cultivars Pyrodwarf and Conference
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Malus domestica
-
leaf
-
Pyrus communis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrokaempferol + 2-oxoglutarate + O2
-
Malus domestica kaempferol + succinate + CO2 + H2O
-
ir
dihydrokaempferol + 2-oxoglutarate + O2
-
Pyrus communis kaempferol + succinate + CO2 + H2O
-
ir
dihydromyricetin + 2-oxoglutarate + O2
-
Malus domestica myricetin + succinate + CO2 + H2O
-
ir
dihydromyricetin + 2-oxoglutarate + O2
-
Pyrus communis myricetin + succinate + CO2 + H2O
-
ir
dihydroquercetin + 2-oxoglutarate + O2
-
Malus domestica quercetin + succinate + CO2 + H2O
-
ir
dihydroquercetin + 2-oxoglutarate + O2
-
Pyrus communis quercetin + succinate + CO2 + H2O
-
ir

Synonyms

Synonyms Comment Organism
FLS
-
Malus domestica
FLS
-
Pyrus communis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Malus domestica
30
-
-
Pyrus communis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.25
-
-
Malus domestica
7.25
-
-
Pyrus communis

Cofactor

Cofactor Comment Organism Structure
ascorbate required Malus domestica
ascorbate required Pyrus communis