Literature summary for 1.14.20.12 extracted from

Brady, S.; Clardy, J.
Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom (2005), Angew. Chem. Int. Ed. Engl., 44, 7045-7048 .

Search for more literature for 1.14.20.12

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	uncultured organism

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2	uncultured organism	-	3-[(E)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
uncultured organism	Q108L2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2	-	uncultured organism	3-[(E)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O	-	?

Synonyms

Synonyms	Comment	Organism
isnB	-	uncultured organism

General Information

General Information	Comment	Organism
physiological function	presence of isonitrile synthase IsnA and IsnB alone are sufficient to generate 3-[(E)-2-isocyanoethenyl]-1H-indole from L-Trp and ribulose 5-phosphate. The origin of the isocyanide carbon atom in 3-[(E)-2-isocyanoethenyl]-1H-indole is the C2 atom of ribulose 5-phosphate, or a tautomerically equivalent sugar	uncultured organism

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Release 2023.1 (January 2023)