Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.19.77 extracted from

  • Werner, E.R.; Keller, M.A.; Sailer, S.; Lackner, K.; Koch, J.; Hermann, M.; Coassin, S.; Golderer, G.; Werner-Felmayer, G.; Zoeller, R.A.; Hulo, N.; Berger, J.; Watschinger, K.
    The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens (2020), Proc. Natl. Acad. Sci. USA, 117, 7792-7798 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.77

Protein Variants

Protein Variants Comment Organism
H121A inactive Homo sapiens
H122A inactive Homo sapiens
H131A the mutant show strongly reduced activity compared to the wild type enzyme Homo sapiens
H187A inactive Homo sapiens
H191A inactive Homo sapiens
H215A inactive Homo sapiens
H218A inactive Homo sapiens
H219A inactive Homo sapiens
H96A inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
membrane transmembrane protein Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ Homo sapiens
-
 a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HAP-1 cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-O-pyrenedecyl-sn-glycero-3-phosphoethanolamine + NADPH + O2 + H+
-
 Homo sapiens ?
-
 ?
a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Homo sapiens a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
PEDS
-
 Homo sapiens
TMEM189
-
 Homo sapiens