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Literature summary for 1.14.19.77 extracted from

  • Gallego-Garcia, A.; Monera-Girona, A.J.; Pajares-Martinez, E.; Bastida-Martinez, E.; Perez-Castano, R.; Iniesta, A.A.; Fontes, M.; Padmanabhan, S.; Elias-Arnanz, M.
    A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis (2019), Science, 366, 128-132 .
    View publication on PubMed
Search for more literature for 1.14.19.77

Protein Variants

Protein Variants Comment Organism
H103A inactive Myxococcus xanthus
H104A inactive Myxococcus xanthus
H113A inactive Myxococcus xanthus
H120A inactive Homo sapiens
H121A inactive Homo sapiens
H130A inactive Homo sapiens
H164A inactive Myxococcus xanthus
H168A inactive Myxococcus xanthus
H183A the mutant shows enzymatic activity Myxococcus xanthus
H186A inactive Homo sapiens
H190A inactive Homo sapiens
H190A the mutant shows enzymatic activity Myxococcus xanthus
H191A inactive Myxococcus xanthus
H194A inactive Myxococcus xanthus
H195A inactive Myxococcus xanthus
H206A the mutant shows enzymatic activity Homo sapiens
H213A the mutant shows enzymatic activity Homo sapiens
H214A the mutant shows weak enzymatic activity Homo sapiens
H217A inactive Homo sapiens
H218A inactive Homo sapiens
H218A the mutant shows enzymatic activity Myxococcus xanthus
H222A the mutant shows enzymatic activity Homo sapiens
H78A inactive Myxococcus xanthus
H95A inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Myxococcus xanthus 16020
-
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Iron contains two equivalents of iron Myxococcus xanthus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alkyl ether plasmanylethanolamine + NADPH + O2 Myxococcus xanthus
-
 vinyl ether phosphatidylethanolamine + NADP+ + H2O
-
 ?
alkyl ether plasmanylethanolamine + NADPH + O2 Homo sapiens
-
 vinyl ether phosphatidylethanolamine + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens A5PLL7
-
-
Myxococcus xanthus Q9AE87
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Myxococcus xanthus
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HAP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alkyl ether plasmanylethanolamine + NADPH + O2
-
 Myxococcus xanthus vinyl ether phosphatidylethanolamine + NADP+ + H2O
-
 ?
alkyl ether plasmanylethanolamine + NADPH + O2
-
 Homo sapiens vinyl ether phosphatidylethanolamine + NADP+ + H2O
-
 ?
iso15:0-O-alkylglycerol-bis-trimethylsilyl ether + NADPH + O2
-
 Myxococcus xanthus iso15:0-dimethylacetal + NADP+ + H2O
-
 ?
iso16:0-O-alkylglycerol-bis-trimethylsilyl ether + NADPH + O2
-
 Homo sapiens iso16:0-dimethylacetal + NADP+ + H2O
-
 ?
iso18:0-O-alkylglycerol-bis-trimethylsilyl ether + NADPH + O2
-
 Homo sapiens iso18:0-dimethylacetal + NADP+ + H2O
-
 ?
iso18:1-O-alkylglycerol-bis-trimethylsilyl ether + NADPH + O2
-
 Homo sapiens iso18:1-dimethylacetal + NADP+ + H2O
-
 ?

Subunits

Subunits Comment Organism
? x * 31000, SDS-PAGE Myxococcus xanthus
? x * 31000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
CarF
-
 Myxococcus xanthus
TMEM189
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme mediates light-induced carotenogenesis and and plasmalogen formation in Myxococcus xanthus Myxococcus xanthus