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Literature summary for 1.14.19.59 extracted from
- A tryptophan 6-halogenase and an amidotransferase are involved in thienodolin biosynthesis (2014), ChemBioChem, 15, 1011-1020 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces albogriseolus | A1E280 | - |
- |
| Streptomyces albogriseolus MJ286-76F7 | A1E280 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ThdH | - |
Streptomyces albogriseolus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the first step in thienodolin biosynthesis is catalyzed by a tryptophan 6-halogenase, and the last step is the formation of a carboxylic amide group catalyzed by an amidotransferase. Gene ThdH encodes tryptophan 6-halogenase, which catalyzes the regioselective chlorination of tryptophan to 6-chlorotryptophan. This flavin-dependent halogenase requires the participation of a flavin reductase, which is encoded by thdF. A gene deletion mutant of tryptophan 6-halogenase ThdH is not able to produce thienedolin | Streptomyces albogriseolus |
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Release 2023.1 (January 2023)
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