Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.19.57 extracted from

  • Agarwal, V.; El Gamal, A.; Yamanaka, K.; Poth, D.; Kersten, R.; Schorn, M.; Allen, E.; Moore, B.
    Biosynthesis of polybrominated aromatic organic compounds by marine bacteria (2014), Nat. Chem. Biol., 10, 640-647 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.57

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Pseudoalteromonas luteoviolacea

Organism

Organism UniProt Comment Textmining
Pseudoalteromonas luteoviolacea
-
-
-
Pseudoalteromonas luteoviolacea 2ta16
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + 3 FADH2 + 3 bromide + 3 O2
-
 Pseudoalteromonas luteoviolacea 3,4,5-tribromo-1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + 3 FAD + 6 H2O
-
 ?
1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + FADH2 + bromide + O2
-
 Pseudoalteromonas luteoviolacea 5-bromo-1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + FAD + 2 H2O
-
 ?
4,5-dibromo-1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + FADH2 + bromide + O2
-
 Pseudoalteromonas luteoviolacea 3,4,5-tribromo-1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + FAD + 2 H2O
-
 ?
5-bromo-1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + FADH2 + bromide + O2
-
 Pseudoalteromonas luteoviolacea 4,5-dibromo-1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + FAD + 2 H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Pseudoalteromonas luteoviolacea
NADPH
-
 Pseudoalteromonas luteoviolacea

General Information

General Information Comment Organism
physiological function deletion of gene Bmp2 abolishes the production of bromopyrroles. In the presence of Escherichia coli flavin reductase SsuE, NADPH and bromide, Bmp2 catalyzes the bromination of pyrrolyl-S-Bmp1(acyl carrier protein) to mono-, di- and tribromopyrrolyl-S-Bmp1(acyl carrier protein) Pseudoalteromonas luteoviolacea