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Literature summary for 1.14.19.53 extracted from

  • Enright, J.M.; Toomey, M.B.; Sato, S.Y.; Temple, S.E.; Allen, J.R.; Fujiwara, R.; Kramlinger, V.M.; Nagy, L.D.; Johnson, K.M.; Xiao, Y.; How, M.J.; Johnson, S.L.; Roberts, N.W.; Kefalov, V.J.; Guengerich, F.P.; Corbo, J.C.
    Cyp27c1 red-shifts the spectral sensitivity of photoreceptors by converting vitamin A1 into A2 (2015), Curr. Biol., 25, 3048-3057 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Danio rerio A8WGA0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinal + 2 reduced adrenodoxin + 2 H+ + O2
-
 Danio rerio all-trans-3,4-didehydroretinal + 2 oxidized adrenodoxin + 2 H2O
-
 ?
all-trans-retinoic acid + 2 reduced adrenodoxin + 2 H+ + O2
-
 Danio rerio all-trans-3,4-didehydroretinoic acid + 2 oxidized adrenodoxin + 2 H2O
-
 ?
all-trans-retinol + 2 reduced adrenodoxin + 2 H+ + O2
-
 Danio rerio all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
 Danio rerio

General Information

General Information Comment Organism
physiological function knockout of Cyp27c1 in zebrafish abrogates production of vitamin A2, eliminates the animal's ability to red-shift its photoreceptor spectral sensitivity, and reduces its ability to see and respond to near-infrared light Danio rerio

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
800
-
 all-trans-retinal 37°C, pH not specified in the publication Danio rerio
800
-
 all-trans-retinoic acid 37°C, pH not specified in the publication Danio rerio
1900
-
 all-trans-retinol 37°C, pH not specified in the publication Danio rerio