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Literature summary for 1.14.19.51 extracted from

  • Ikezawa, N.; Iwasa, K.; Sato, F.
    Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells (2008), J. Biol. Chem., 283, 8810-8821.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae Coptis japonica

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome sequence contains a putative endoplasmic reticulum-localizing signal Coptis japonica
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 Coptis japonica
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(S)-corytuberine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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?

Organism

Organism UniProt Comment Textmining
Coptis japonica A8CDR5
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Source Tissue

Source Tissue Comment Organism Textmining
cell culture
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Coptis japonica
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R,S)-codamine + [reduced NADPH-hemoprotein reductase] + O2
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Coptis japonica 2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,10-diol + [oxidized NADPH-hemoprotein reductase] + 2 H2O 12% of the activity with reticuline. The major product is (R,S)-orientaline, 4'-O-demethylation product of (R,S)-codamine, and the minor one is proposed to be the same compound as (R,S)-orientaline-derived phenol coupling product ?
(R,S)-norreticuline + [reduced NADPH-hemoprotein reductase] + O2
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Coptis japonica 2,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,11-diol + [oxidized NADPH-hemoprotein reductase] + 2 H2O 19% of the activity with reticuline ?
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2
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Coptis japonica 2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,10-diol + [oxidized NADPH-hemoprotein reductase] + 2 H2O 2% of the activity with reticuline ?
(S)-orientaline + [reduced NADPH-hemoprotein reductase] + O2
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Coptis japonica 2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,10-diol + [oxidized NADPH-hemoprotein reductase] + 2 H2O 2.7% of the activity with reticuline ?
(S)-reticuline + [reduced NADPH-hemoprotein reductase] + O2
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Coptis japonica (S)-corytuberine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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?
additional information CĀ–C phenol-coupling reaction, requires NADPH and oxygen. The enzyme is specific for S-enantiomer of substrate Coptis japonica ?
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?

Synonyms

Synonyms Comment Organism
corytuberine synthase
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Coptis japonica
CYP80G2
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Coptis japonica

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
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Coptis japonica