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Literature summary for 1.14.19.41 extracted from
- Inhibition and substrate specificity of yeast DELTA22-desaturase (1990), Biochem. Biophys. Res. Commun., 173, 60-66.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (20S)-21-isocyano-20-methylpregn-5-en-3beta-ol | complete inhibition at 0.15 mM | Saccharomyces cerevisiae |  |
| additional information | not inhibited by desmosterol, 24-methylenecholesterol, and 24-bromocholesterol | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Saccharomyces cerevisiae | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 22,23-dihydrobrassicasterol + NADPH + H+ + O2 | highest activity | Saccharomyces cerevisiae | brassicasterol + NADP+ + H2O | - |
? | |
| clionasterol + NADPH + H+ + O2 | - |
Saccharomyces cerevisiae | poriferasterol + NADP+ + H2O | - |
? | |
| sitosterol + NADPH + H+ + O2 | - |
Saccharomyces cerevisiae | stigmasterol + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DELTA22-desaturase | - |
Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Saccharomyces cerevisiae | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.015 | - |
at 27°C, pH not specified in the publication | Saccharomyces cerevisiae | (20S)-21-isocyano-20-methylpregn-5-en-3beta-ol | |
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