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Literature summary for 1.14.19.39 extracted from

  • Zhou, X.; Green, A.; Singh, S.
    Caenorhabditis elegans ?12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the DELTA12 and DELTA15 positions (2011), J. Biol. Chem., 286, 43644-43650.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene fat-2, sequence comparison and phylogenetic tree, expression in Saccharomyces cerevisiae strain S288C Caenorhabditis elegans

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans G5EGA5 gene fat-2
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
linoleate + AH2 + O2
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Caenorhabditis elegans crepenynate + A + 2 H2O
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?
additional information the enzyme is able to desaturate C16 and C18 fatty acids. When recombinantly expressed in yeast cells, the enzyme can also catalyze DELTA15 desaturation. The recombinant enzyme can also produce C14:2DELTA9,12, C15:2DELTA9,12, C17:2DELTA9,12, and C18:4DELTA6,9,12,15 when C14:1DELTA9, C15:1DELTA9, C17:1DELTA9, and C18:3DELTA6,9,12 substrates are available in yeast cells, product mass spectrometry analysis Caenorhabditis elegans ?
-
?
oleate + AH2 + O2 recombinant enzyme Caenorhabditis elegans linoleic acid + linolenic acid + A + 2 H2O
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?
palmitoleic acid + O2 recombinant enzyme Caenorhabditis elegans hexadecadienoic acid + hexadecatrienoic acid + A + 2 H2O
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?

Synonyms

Synonyms Comment Organism
DELTA12-desaturase
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Caenorhabditis elegans
FAT-2
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Caenorhabditis elegans
fatty acid DELTA12-desaturase
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Caenorhabditis elegans