Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is independently induced by oxygen, and temperature, while chilling alone is not sufficient to raise the enzyme activity. Chilling and lowered temperature cause an increase in desaturase activity, increased membrane unsaturation and subsequently fluidity, followed by phagocytosis, overview | Acanthamoeba castellanii |
Cloned (Comment) | Organism |
---|---|
expression in Saccharomyces cerevisiae | Acanthamoeba castellanii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Acanthamoeba castellanii | key enzyme in adaptation to low temperature, sequential changes in fatty acid composition on lowering environmental temperature, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acanthamoeba castellanii | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | cell growth between 4°C and 32°C | Acanthamoeba castellanii | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | key enzyme in adaptation to low temperature, sequential changes in fatty acid composition on lowering environmental temperature, overview | Acanthamoeba castellanii | ? | - |
? | |
additional information | substrate specificity, the recombinant enzyme catalyzes also the DELTA15-desaturation of fatty acids, and is capable of producing very unusual n-1 polyunsaturated products, overview | Acanthamoeba castellanii | ? | - |
? | |
oleate + AH2 + O2 | oxygenation at the sn-2 position | Acanthamoeba castellanii | linoleate + A + 2 H2O | - |
? | |
palmitoleoate + AH2 + O2 | via intermediate DELTA9,12 hexadecadienoate | Acanthamoeba castellanii | 9,12,15-hexadecatrienoate + A + H2O | the product is n-1 polyunsaturated | ? | |
phosphatidylcholine + AH2 + O2 | - |
Acanthamoeba castellanii | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DELTA12-fatty acid desaturase | - |
Acanthamoeba castellanii |