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Literature summary for 1.14.19.30 extracted from
- DELTA5 Desaturase activity in rat kidney microsomes (1993), Mol. Cell. Biochem., 129, 31-37.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] | the DELTA5 desaturase activity in kidney microsomes increases linearly with the substrate concentration up to 0.02 mM | Rattus norvegicus |  |
| additional information | neither the cytosolic renal fraction nor the cytosolic liver fraction enhance the DELTA5 desaturase activity | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.056 | - |
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] | at pH 7.0 and 36°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ | Rattus norvegicus | - |
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ | - |
Rattus norvegicus | (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DELTA5 desaturase | - |
Rattus norvegicus |
| DES5 | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | dependent on | Rattus norvegicus | |
| CoA | dependent on | Rattus norvegicus | |
| cytochrome b5 | dependent on | Rattus norvegicus | |
| NADH | dependent on | Rattus norvegicus | |
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