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Literature summary for 1.14.19.30 extracted from

  • Cho, H.; Nakamura, M.; Clarke, S.
    Cloning, expression, and fatty acid regulation of the human DELTA-5 desaturase (1999), J. Biol. Chem., 274, 37335-37339.
    View publication on PubMed
Search for more literature for 1.14.19.30

Cloned(Commentary)

Cloned (Comment) Organism
expressed in CHO cells Rattus norvegicus
expressed in CHO cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ Rattus norvegicus
-
 (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
 (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ Rattus norvegicus
-
 (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
 (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y5Q0
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain most abundant Homo sapiens
-
heart most abundant Homo sapiens
-
kidney
-
 Homo sapiens
-
liver most abundant Homo sapiens
-
lung
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
-
 Rattus norvegicus (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
-
 Rattus norvegicus (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?
additional information no activity with 18:3(n-3) Rattus norvegicus ?
-
 ?
additional information no activity with 18:3(n-3) Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
D5D
-
 Rattus norvegicus
D5D
-
 Homo sapiens
delta-5 desaturase
-
 Rattus norvegicus
delta-5 desaturase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
 Rattus norvegicus
cytochrome b5
-
 Homo sapiens

Expression

Organism Comment Expression
Rattus norvegicus when rats are fed a diet containing 10% (v/v) safflower oil or menhaden fish oil, the level of hepatic mRNA is 25% of that found in the liver of rats fed a fat-free diet or a diet containing triolein down