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Literature summary for 1.14.19.30 extracted from

  • Baugh, S.; Pabba, P.; Barbosa, J.; Coulter, E.; Desai, U.; Gay, J.; Gopinathan, S.; Han, Q.; Hari, R.; Kimball, S.; Nguyen, H.; Ni, C.; Powell, D.; Smith, A.; Terranova, K.; Wilson, A.; Yu, X.; Lombardo, V.
    Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome (2015), Bioorg. Med. Chem. Lett., 25, 3836-3839.
    View publication on PubMed
Search for more literature for 1.14.19.30

Inhibitors

Inhibitors Comment Organism Structure
2-(2,2,3,3,3-pentafluoropropoxy)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-5,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-4,6-dione
-
 Mus musculus
2-amino-5-chloro-N-(3-chlorophenyl)benzamide
-
 Mus musculus
2-amino-N-(3-chlorophenyl)-5-fluorobenzamide
-
 Mus musculus
2-amino-N-(3-chlorophenyl)benzamide
-
 Mus musculus
2-amino-N-(3-fluorophenyl)benzamide
-
 Mus musculus
2-amino-N-[3-(propan-2-yl)phenyl]benzamide
-
 Mus musculus
4-isopentoxyaniline
-
 Mus musculus
5-bromo-N-(3-chlorophenyl)-1H-indazol-3-amine
-
 Mus musculus
5-chloro-N-(3-chlorophenyl)-1H-indazol-3-amine
-
 Mus musculus
dibenzoazepine
-
 Mus musculus
N-(3-chlorophenyl)-1H-indazol-3-amine
-
 Mus musculus
N-(3-chlorophenyl)-2,3-dihydro-1H-inden-1-amine
-
 Mus musculus
N-(3-chlorophenyl)-2-hydroxy-5-methoxybenzamide
-
 Mus musculus
N-(3-chlorophenyl)-2-hydroxybenzamide
-
 Mus musculus
N-(3-chlorophenyl)-5-(trifluoromethoxy)-1H-indazol-3-amine
-
 Mus musculus
N-(3-chlorophenyl)-5-(trifluoromethyl)-1H-indazol-3-amine
-
 Mus musculus
N-(3-chlorophenyl)-5-ethoxy-2-hydroxybenzamide
-
 Mus musculus
N-(3-chlorophenyl)-5-fluoro-1H-indazol-3-amine
-
 Mus musculus
N-(3-chlorophenyl)-5-methoxy-1H-indazol-3-amine
-
 Mus musculus
N-(3-chlorophenyl)-5-methyl-1H-indazol-3-amine
-
 Mus musculus
N-(3-chlorophenyl)furo[3,2-c]pyridin-4-amine
-
 Mus musculus
N-(3-chlorophenyl)naphthalen-1-amine
-
 Mus musculus
N-(3-chlorophenyl)quinazolin-4-amine
-
 Mus musculus
N-(3-chlorophenyl)quinolin-4-amine
-
 Mus musculus
N-(3-chlorophenyl)thieno[2,3-d]pyrimidin-4-amine
-
 Mus musculus
N-(3-chlorophenyl)thieno[3,2-d]pyrimidin-4-amine
-
 Mus musculus
N-(3-fluorophenyl)-1H-indazol-3-amine
-
 Mus musculus
sesamin
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
delta-5 desaturase
-
 Mus musculus
FADS1
-
 Mus musculus
fatty acid desaturase
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000005
-
 pH and temperature not specified in the publication Mus musculus 5-chloro-N-(3-chlorophenyl)-1H-indazol-3-amine
0.000006
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)-5-methyl-1H-indazol-3-amine
0.000008
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)-5-methoxy-1H-indazol-3-amine
0.000011
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)quinazolin-4-amine
0.000015
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)-2-hydroxy-5-methoxybenzamide
0.000017
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)naphthalen-1-amine
0.000018
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)quinolin-4-amine
0.000021
-
 pH and temperature not specified in the publication Mus musculus 5-bromo-N-(3-chlorophenyl)-1H-indazol-3-amine
0.000034
-
 pH and temperature not specified in the publication Mus musculus 2-amino-5-chloro-N-(3-chlorophenyl)benzamide
0.00005
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)thieno[3,2-d]pyrimidin-4-amine
0.000058
-
 pH and temperature not specified in the publication Mus musculus sesamin
0.000058
-
 pH and temperature not specified in the publication Mus musculus 2-amino-N-(3-chlorophenyl)benzamide
0.000058
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)-5-fluoro-1H-indazol-3-amine
0.000059
-
 pH and temperature not specified in the publication Mus musculus N-(3-fluorophenyl)-1H-indazol-3-amine
0.000067
-
 pH and temperature not specified in the publication Mus musculus 2-amino-N-(3-chlorophenyl)-5-fluorobenzamide
0.000084
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)-1H-indazol-3-amine
0.000173
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)-2,3-dihydro-1H-inden-1-amine
0.000174
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)-2-hydroxybenzamide
0.000254
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)-5-(trifluoromethyl)-1H-indazol-3-amine
0.00026
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)thieno[2,3-d]pyrimidin-4-amine
0.000371
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)furo[3,2-c]pyridin-4-amine
0.000516
-
 pH and temperature not specified in the publication Mus musculus 2-amino-N-(3-fluorophenyl)benzamide
0.000843
-
 pH and temperature not specified in the publication Mus musculus 2-amino-N-[3-(propan-2-yl)phenyl]benzamide
0.000925
-
 pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)-5-ethoxy-2-hydroxybenzamide
0.003
-
 IC50 above 0.003 mM, pH and temperature not specified in the publication Mus musculus N-(3-chlorophenyl)-5-(trifluoromethoxy)-1H-indazol-3-amine