Literature summary for 1.14.19.3 extracted from

Nagano, N.; Okada, T.; Kayama, K.; Hosono, S.; Kitamura, Y.; Takahashi, S.
Delta-6 desaturase activity during the first year of life in preterm infants (2016), Prostaglandins Leukot. Essent. Fatty Acids, 115, 8-11 .

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Application

Application	Comment	Organism
nutrition	evaluating D6D activity in preterm infants is important for better nutritional management	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	D6D activity in preterm, term, and post-natals is estimated by the 20:3n-6/18:2n-6 ratio	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	term neonates have high delta-6 desaturase activity. At birth, preterm infants have D6D activity as high as that of term infants, D6D activity declines to about one-third at one month, then further decreases to about one-sixth at six months and remained stable until 12 months. The postnatal change in arachidonic acid exhibis a similar pattern to that of D6D activity	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	D6D activity in preterm, term, and post-natals is estimated by the 20:3n-6/18:2n-6 ratio	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
D6D	-	Homo sapiens
DELTA-6 desaturase	-	Homo sapiens

General Information

General Information	Comment	Organism
additional information	polyunsaturated fatty acid profile at birth and its postnatal change, overview	Homo sapiens
physiological function	neonates have high delta-6 desaturase (D6D) activity, which is important for regulating polyunsaturated fatty acid's (PUFA) nutritional status. At birth, preterm infants have D6D activity as high as that of term infants, D6D activity declines to about one-third at one month, then further decreases to about one-sixth at six months and remained stable until 12 months. The postnatal change in arachidonic acid exhibits a similar pattern to that of D6D activity. Docosahexaenoic acid shows a transient decrease at one month and recovers to the cord blood level at six months. Enzyme D6D may regulate PUFA profile in preterm infants, especially during the early postnatal period. Long-chain polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA) and docosahexaenoic acid (DHA), are critical nutrients for humans, as humans do not have the enzymes to synthesize PUFA from acetyl CoA, but are instead able to produce AA and DHA from precursor PUFAs, linoleic acid (LA), and alpha-linolenic acid (ALA), respectively	Homo sapiens

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Release 2023.1 (January 2023)