Literature summary for 1.14.19.3 extracted from

Geay, F.; Tinti, E.; Mellery, J.; Michaux, C.; Larondelle, Y.; Perpete, E.; Kestemont, P.
Cloning and functional characterization of DELTA6 fatty acid desaturase (FADS2) in Eurasian perch (Perca fluviatilis) (2016), Comp. Biochem. Physiol. B, 191, 112-125 .

Search for more literature for 1.14.19.3

Cloned(Commentary)

Cloned (Comment)	Organism
gene fads2, DNA and amino acid sequence determination and analysis, cloning of two alternative splicing transcripts named fads2-AS1 and fads2-AS2, quantitative real-time PCR expression analysis, recombinant expression in yeast, which shows fully functional DELTA6 desaturation activity toward C18 polyunsaturated fatty acid substrates, without residual DELTA5 and DELTA8 desaturase activities	Perca fluviatilis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	the enzyme contains two transmembrane domains	Perca fluviatilis	-	-

Organism

Organism	UniProt	Comment	Textmining
Perca fluviatilis	A0A0A1E9M5	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Perca fluviatilis	-
intestine	-	Perca fluviatilis	-
liver	-	Perca fluviatilis	-
additional information	the fads2 transcript is mainly expressed in the liver and intestine and exhibits a typical gene expression pattern of freshwater species while fads2-AS1 and fads2-AS2 genes are highly expressed in the brain, followed by the liver and intestine, quantitative real-time PCR expression analysis	Perca fluviatilis	-

Synonyms

Synonyms	Comment	Organism
DELTA6 fatty acid desaturase	-	Perca fluviatilis
FADS2	-	Perca fluviatilis
fatty acid desaturase 2	-	Perca fluviatilis

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome b5	the enzyme contains an N-terminal cytochrome b5 domain with the HPGG motif	Perca fluviatilis

General Information

General Information	Comment	Organism
metabolism	the enzyme seems to be a rate-limiting enzyme of the long-chain polyunsaturated fatty acids (LC-PUFAs) biosynthesis	Perca fluviatilis
additional information	the enzyme sequence displays the typical structure of microsomal FADS2 including two transmembrane domains and an N-terminal cytochrome b5 domain with the HPGG motif	Perca fluviatilis

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Release 2023.1 (January 2023)