Literature summary for 1.14.19.29 extracted from

Song, L.; Zhang, Y.; Li, S.; Hu, J.; Yin, W.; Chen, Y.; Hao, S.; Wang, B.; Wang, R.; Hu, Z.
Identification of the substrate recognition region in the DELTA6-fatty acid and DELTA8-sphingolipid desaturase by fusion mutagenesis (2014), Planta, 239, 753-763.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Saccharomyces cerevisiae strain InvSc1	Ribes nigrum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+	Ribes nigrum	32.5% conversion rate	(4R,8E)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O	-	?
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+	Ribes nigrum	32.5% conversion rate	(4R,8Z)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Ribes nigrum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+	32.5% conversion rate	Ribes nigrum	(4R,8E)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O	-	?
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+	32.5% conversion rate	Ribes nigrum	(4R,8Z)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O	-	?
additional information	the enzyme has no DELTA6-desaturase activity	Ribes nigrum	?	-	?

Synonyms

Synonyms	Comment	Organism
D8A	-	Ribes nigrum
D8D	-	Ribes nigrum
DELTA8-sphingolipid desaturase	-	Ribes nigrum

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome b5	-	Ribes nigrum

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Release 2023.1 (January 2023)