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Literature summary for 1.14.19.29 extracted from

  • Habel, A.; Sperling, P.; Bartram, S.; Heinz, E.; Boland, W.
    Conformational studies on the DELTA8(E,Z)-sphingolipid desaturase from Helianthus annuus with chiral fluoropalmitic acids as mechanistic probes (2010), J. Org. Chem., 75, 4975-4982.
    View publication on PubMed
Search for more literature for 1.14.19.29

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae Helianthus annuus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+ Helianthus annuus
-
 (4R,8E)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O
-
 ?
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+ Helianthus annuus
-
 (4R,8Z)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Helianthus annuus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+
-
 Helianthus annuus (4R,8E)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O
-
 ?
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+
-
 Helianthus annuus (4R,8Z)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O
-
 ?
fluorinated phytosphinganine + ferrocytochrome b5 + O2 + H+ the presence of a fluorine atom at the position of the initial hydrogen removal C8-HR leads to a complete suppression of the desaturation reaction, while replacement of C8-HS with fluorine generates a mixture of mainly (Z)- and trace amounts of (E)-fluoroolefine Helianthus annuus ?
-
 ?

Synonyms

Synonyms Comment Organism
DELTA8(E,Z)-sphingolipid desaturase
-
 Helianthus annuus

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
 Helianthus annuus