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Literature summary for 1.14.19.21 extracted from

  • Yoshiyama-Yanagawa, T.; Enya, S.; Shimada-Niwa, Y.; Yaguchi, S.; Haramoto, Y.; Matsuya, T.; Shiomi, K.; Sasakura, Y.; Takahashi, S.; Asashima, M.; Kataoka, H.; Niwa, R.
    The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme (2011), J. Biol. Chem., 286, 25756-25762.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.21

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Drosophila melanogaster S2 cells Caenorhabditis elegans
expressed in Drosophila melanogaster S2 cells Bombyx mori
expressed in Drosophila melanogaster S2 cells Xenopus laevis
expressed in Drosophila melanogaster S2 cells Danio rerio
expressed in Drosophila melanogaster S2 cells Hemicentrotus pulcherrimus

Protein Variants

Protein Variants Comment Organism
C122A inactive Caenorhabditis elegans
C178A inactive Xenopus laevis
D234A inactive Caenorhabditis elegans
H190A inactive Bombyx mori
H282A inactive Bombyx mori

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Caenorhabditis elegans
-
-
microsome
-
 Bombyx mori
-
-
microsome
-
 Xenopus laevis
-
-
microsome
-
 Danio rerio
-
-
microsome
-
 Ciona intestinalis
-
-
microsome
-
 Hemicentrotus pulcherrimus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + O2 + NADH + H+ Bombyx mori
-
 cholesta-5,7-dien-3beta-ol + NAD+ + H2O
-
 ?
cholesterol + O2 + NADH + H+ Caenorhabditis elegans
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADH + H+ Xenopus laevis
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADH + H+ Danio rerio
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADH + H+ Ciona intestinalis
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADH + H+ Hemicentrotus pulcherrimus
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+ Caenorhabditis elegans
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+ Bombyx mori
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+ Xenopus laevis
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+ Danio rerio
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+ Ciona intestinalis
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+ Hemicentrotus pulcherrimus
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bombyx mori Q1JUZ2
-
-
Caenorhabditis elegans Q17938
-
-
Ciona intestinalis F7J186
-
-
Danio rerio Q6DHJ3
-
-
Hemicentrotus pulcherrimus F7J188
-
-
Xenopus laevis F7J184
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + O2 + NADH + H+
-
 Bombyx mori cholesta-5,7-dien-3beta-ol + NAD+ + H2O
-
 ?
cholesterol + O2 + NADH + H+
-
 Caenorhabditis elegans cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADH + H+
-
 Xenopus laevis cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADH + H+
-
 Danio rerio cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADH + H+
-
 Ciona intestinalis cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADH + H+
-
 Hemicentrotus pulcherrimus cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+
-
 Caenorhabditis elegans cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+
-
 Bombyx mori cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+
-
 Xenopus laevis cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+
-
 Danio rerio cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+
-
 Ciona intestinalis cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+
-
 Hemicentrotus pulcherrimus cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cholesterol 7,8-dehydrogenase
-
 Caenorhabditis elegans
cholesterol 7,8-dehydrogenase
-
 Bombyx mori
cholesterol 7,8-dehydrogenase
-
 Xenopus laevis
cholesterol 7,8-dehydrogenase
-
 Danio rerio
cholesterol 7,8-dehydrogenase
-
 Ciona intestinalis
cholesterol 7,8-dehydrogenase
-
 Hemicentrotus pulcherrimus
DAF-36/Neverland
-
 Caenorhabditis elegans
DAF-36/Neverland
-
 Xenopus laevis
DAF-36/Neverland
-
 Danio rerio
DAF-36/Neverland
-
 Ciona intestinalis
DAF-36/Neverland
-
 Hemicentrotus pulcherrimus
Neverland
-
 Bombyx mori
Nvd
-
 Bombyx mori
Nvd
-
 Xenopus laevis
Nvd
-
 Danio rerio
Nvd
-
 Ciona intestinalis
Nvd
-
 Hemicentrotus pulcherrimus

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Caenorhabditis elegans
NADH
-
 Bombyx mori
NADH
-
 Xenopus laevis
NADH
-
 Danio rerio
NADH
-
 Ciona intestinalis
NADH
-
 Hemicentrotus pulcherrimus
NADPH
-
 Caenorhabditis elegans
NADPH
-
 Bombyx mori
NADPH
-
 Xenopus laevis
NADPH
-
 Danio rerio
NADPH
-
 Ciona intestinalis
NADPH
-
 Hemicentrotus pulcherrimus
[2Fe-2S]-center
-
 Caenorhabditis elegans
[2Fe-2S]-center
-
 Bombyx mori
[2Fe-2S]-center
-
 Xenopus laevis
[2Fe-2S]-center
-
 Danio rerio
[2Fe-2S]-center
-
 Ciona intestinalis
[2Fe-2S]-center
-
 Hemicentrotus pulcherrimus