Literature summary for 1.14.19.21 extracted from

Wollam, J.; Magomedova, L.; Magner, D.B.; Shen, Y.; Rottiers, V.; Motola, D.L.; Mangelsdorf, D.J.; Cummins, C.L.; Antebi, A.
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity (2011), Aging Cell, 10, 879-884.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Sf9 cells	Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cholesterol + O2 + NADPH + H+	Caenorhabditis elegans	-	cholesta-5,7-dien-3beta-ol + NADP+ + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cholesterol + O2 + NADPH + H+	-	Caenorhabditis elegans	cholesta-5,7-dien-3beta-ol + NADP+ + H2O	-	?

Synonyms

Synonyms	Comment	Organism
DAF-36	-	Caenorhabditis elegans

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Caenorhabditis elegans

General Information

General Information	Comment	Organism
physiological function	the enzyme regulates DAF-12 activities for reproductive development and longevity by controlling dafachronic acids production	Caenorhabditis elegans

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Release 2023.1 (January 2023)