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Literature summary for 1.14.19.21 extracted from

  • Wollam, J.; Magomedova, L.; Magner, D.B.; Shen, Y.; Rottiers, V.; Motola, D.L.; Mangelsdorf, D.J.; Cummins, C.L.; Antebi, A.
    The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity (2011), Aging Cell, 10, 879-884.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 cells Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + O2 + NADPH + H+ Caenorhabditis elegans
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + O2 + NADPH + H+
-
 Caenorhabditis elegans cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
DAF-36
-
 Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Caenorhabditis elegans

General Information

General Information Comment Organism
physiological function the enzyme regulates DAF-12 activities for reproductive development and longevity by controlling dafachronic acids production Caenorhabditis elegans